scholarly journals DNA repair gene polymorphisms and benefit from gefitinib in never-smokers with lung adenocarcinoma

Cancer ◽  
2011 ◽  
Vol 117 (14) ◽  
pp. 3201-3208 ◽  
Author(s):  
Ji-Youn Han ◽  
Kyong-Ah Yoon ◽  
Jae Hee Park ◽  
Young Joo Lee ◽  
Geon Kook Lee ◽  
...  
Keyword(s):  
Dna Repair ◽  
Lung Adenocarcinoma ◽  
Gene Polymorphisms ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Never Smokers

DNA repair gene polymorphisms and benefit from gefitinib in never-smokers with lung adenocarcinoma (NSLA).

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 7621-7621
Author(s):  
J. Han ◽  
K. Yoon ◽  
Y. Lee ◽  
G. Lee ◽  
S. Yoon ◽  
...  
Keyword(s):  
Dna Repair ◽  
Lung Adenocarcinoma ◽  
Gene Polymorphisms ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Never Smokers

scholarly journals P1.02-007 TP53 and DNA-Repair Gene Polymorphisms as Risk Factors for the Development of Advanced Lung Adenocarcinoma in Serbia

2017 ◽  
Vol 12 (11) ◽  
pp. S1927
Author(s):  
J. Spasic ◽  
A. Krivokuca ◽  
B. Zaric ◽  
D. Radosavljevic ◽  
B. Perin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dna Repair ◽  
Lung Adenocarcinoma ◽  
Gene Polymorphisms ◽  
Repair Gene ◽  
Dna Repair Gene

Patients with Systemic Sclerosis Present Increased DNA Damage Differentially Associated with DNA Repair Gene Polymorphisms

2014 ◽  
Vol 41 (3) ◽  
pp. 458-465 ◽  
Author(s):  
Gustavo Martelli Palomino ◽  
Carmen L. Bassi ◽  
Isabela J. Wastowski ◽  
Danilo J. Xavier ◽  
Yara M. Lucisano-Valim ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Systemic Sclerosis ◽  
Blood Cells ◽  
Gene Polymorphisms ◽  
Peripheral Blood Cells ◽  
Dna Repair Genes ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Repair Genes

Objective.Patients with systemic sclerosis (SSc) exhibit increased toxicity when exposed to genotoxic agents. In our study, we evaluated DNA damage and polymorphic sites in 2 DNA repair genes (XRCC1Arg399Gln andXRCC4Ile401Thr) in patients with SSc.Methods.A total of 177 patients were studied for DNA repair gene polymorphisms. Fifty-six of them were also evaluated for DNA damage in peripheral blood cells using the comet assay.Results.Compared to controls, the patients as a whole or stratified into major clinical variants (limited or diffuse skin involvement), irrespective of the underlying treatment schedule, exhibited increased DNA damage.XRCC1(rs: 25487) andXRCC4(rs: 28360135) allele and genotype frequencies observed in patients with SSc were not significantly different from those observed in controls; however, theXRCC1Arg399Gln allele was associated with increased DNA damage only in healthy controls and theXRCC4Ile401Thr allele was associated with increased DNA damage in both patients and controls. Further, theXRCC1Arg399Gln allele was associated with the presence of antinuclear antibody and anticentromere antibody. No association was observed between these DNA repair gene polymorphic sites and clinical features of patients with SSc.Conclusion.These results corroborate the presence of genomic instability in SSc peripheral blood cells, as evaluated by increased DNA damage, and show that polymorphic sites of theXRCC1andXRCC4DNA repair genes may differentially influence DNA damage and the development of autoantibodies.

Association of XRCC1 and OGG1 DNA repair gene polymorphisms with rheumatoid arthritis in Egyptian patients

Gene ◽  
2016 ◽  
Vol 578 (1) ◽  
pp. 112-116 ◽  
Author(s):  
Randa H. Mohamed ◽  
Amal S. El-Shal ◽  
Eman E. El-Shahawy ◽  
Sahar M. Abdel Galil
Keyword(s):  
Rheumatoid Arthritis ◽  
Dna Repair ◽  
Gene Polymorphisms ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Egyptian Patients

scholarly journals Are SNP-Smoking Association Studies Needed in Controls? DNA Repair Gene Polymorphisms and Smoking Intensity

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0129374 ◽  
Author(s):  
Zoraida Verde ◽  
Luis Reinoso ◽  
Luis Miguel Chicharro ◽  
Pilar Resano ◽  
Ignacio Sánchez-Hernández ◽  
...  
Keyword(s):  
Dna Repair ◽  
Gene Polymorphisms ◽  
Association Studies ◽  
Repair Gene ◽  
Smoking Intensity ◽  
Dna Repair Gene

scholarly journals Association of cytokine and DNA repair gene polymorphisms with hepatitis B-related hepatocellular carcinoma

2005 ◽  
Vol 34 (6) ◽  
pp. 1310-1318 ◽  
Author(s):  
Chun-Chieh Chen ◽  
Shi-Yi Yang ◽  
Chun-Jen Liu ◽  
Chih-Lin Lin ◽  
Yun-Fan Liaw ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Repair ◽  
Hepatitis B ◽  
Gene Polymorphisms ◽  
Repair Gene ◽  
Dna Repair Gene

scholarly journals Association of DNA repair gene polymorphisms with genotoxic stress in underground coal miners

Mutagenesis ◽  
2017 ◽  
Vol 32 (5) ◽  
pp. 501-509 ◽  
Author(s):  
Maxim Yu Sinitsky ◽  
Varvara I Minina ◽  
Maxim A Asanov ◽  
Arseniy E Yuzhalin ◽  
Anastasia V Ponasenko ◽  
...  
Keyword(s):  
Dna Repair ◽  
Gene Polymorphisms ◽  
Genotoxic Stress ◽  
Coal Miners ◽  
Repair Gene ◽  
Dna Repair Gene

DNA repair gene polymorphisms and risk of head and neck cancer in the Tunisian population

2013 ◽  
Vol 43 (3) ◽  
pp. 217-224 ◽  
Author(s):  
Rim Khlifi ◽  
Imen Kallel ◽  
Bouthaina Hammami ◽  
Amel Hamza-Chaffai ◽  
Ahmed Rebai
Keyword(s):  
Dna Repair ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Gene Polymorphisms ◽  
Tunisian Population ◽  
Repair Gene ◽  
Dna Repair Gene

DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome

2012 ◽  
Vol 36 (2) ◽  
pp. 183-189 ◽  
Author(s):  
Stuart G. Reeves ◽  
Cliff Meldrum ◽  
Claire Groombridge ◽  
Allan Spigelman ◽  
Janina Suchy ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Lynch Syndrome ◽  
Early Onset ◽  
Gene Polymorphisms ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Early Onset Colorectal Cancer
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