DNA repair gene polymorphisms and risk of head and neck cancer in the Tunisian population

2013 ◽  
Vol 43 (3) ◽  
pp. 217-224 ◽  
Author(s):  
Rim Khlifi ◽  
Imen Kallel ◽  
Bouthaina Hammami ◽  
Amel Hamza-Chaffai ◽  
Ahmed Rebai
Keyword(s):  
Dna Repair ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Gene Polymorphisms ◽  
Tunisian Population ◽  
Repair Gene ◽  
Dna Repair Gene

Candidate apoptotic and DNA repair gene approach confirms involvement of ERCC1, ERCC5, TP53 and MDM2 in radiation-induced toxicity in head and neck cancer

Oral Oncology ◽  
2017 ◽  
Vol 67 ◽  
pp. 70-76 ◽  
Author(s):  
D. Borchiellini ◽  
M.C. Etienne-Grimaldi ◽  
R.J. Bensadoun ◽  
K. Benezery ◽  
O. Dassonville ◽  
...  
Keyword(s):  
Dna Repair ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Radiation Induced

scholarly journals DNA Repair Gene XRCC1 Polymorphisms and Head and Neck Cancer Risk: An Updated Meta-Analysis Including 16344 Subjects

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74059 ◽  
Author(s):  
Yin Lou ◽  
Wen-jia Peng ◽  
Dong-sheng Cao ◽  
Juan Xie ◽  
Hong-hong Li ◽  
...  
Keyword(s):  
Dna Repair ◽  
Head And Neck Cancer ◽  
Cancer Risk ◽  
Head And Neck ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Repair Gene ◽  
Dna Repair Gene

Polymorphisms of the XRCC1 DNA repair gene in head and neck cancer

2005 ◽  
Vol 11 (1) ◽  
pp. 22-25 ◽  
Author(s):  
Semra Demokan ◽  
Deniz Demir ◽  
Yusufhan Suoglu ◽  
Erkan Kiyak ◽  
Ugur Akar ◽  
...  
Keyword(s):  
Dna Repair ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Repair Gene ◽  
Dna Repair Gene

scholarly journals The Association Between the XRCC1 Arg399Gln Polymorphism and the Risk of Head and Neck Cancer: An Updated Meta-Analysis Including 14586 Subjects

2021 ◽  
Vol 20 ◽  
pp. 153303382110330
Author(s):  
Shitong Xia ◽  
Sihai Wu ◽  
Minghao Wang
Keyword(s):  
Dna Repair ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Repair Gene ◽  
Xrcc1 Arg399gln ◽  
Dna Repair Gene ◽  
Subgroup Analyses ◽  
Arg399gln Polymorphism

Background: Accumulated evidence shows that DNA repair gene X-ray repair cross complementing group 1 (XRCC1) may determine individual susceptibility to head and neck cancer (HNC) as a major DNA repair gene. However, the results from previous studies have been conflictive and inconsistent. In order to more accurately estimate and integrate the association between XRCC1 Arg399Gln polymorphism and HNC risk, we conducted a meta-analysis including 14586 subjects. Methods: In this meta-analysis, literatures were collected up until September 15, 2020 through multifarious retrieval strategies by searching through electronic databases of PubMed, Cochrane Library, EMBASE, Medline, Web of Science and CNKI. The association between the XRCC1 Arg399Gln polymorphism and HNC was analyzed through calculating summary odds ratios (OR) and 95% confidence intervals (CI). Results: Thirty-one studies consisting of 6025 cases and 8561 controls were identified and analyzed. No significant association between XRCC1 Arg399Gln polymorphisms and HNC risk was found under the allelic (OR = 0.94, 95% CI: 0.82-1.07, P = 0.35), homozygous (OR = 0.99, 95% CI: 0.81-1.21, P = 0.91), heterozygous (OR = 1.01, 95% CI: 0.90-1.13, P = 0.91), dominant (OR = 1.05, 95% CI: 0.85-1.29, P = 0.67) or recessive (OR = 0.93, 95% CI: 0.80-1.08, P = 0.35) genetic models in the overall comparison. In addition, subgroup analyses according to tumor site also displayed no significant association between XRCC1 Arg399Gln polymorphisms and HNC risk. However, subgroup analyses based on ethnicity indicated that HNC risk was significantly related to Arg399Gln genetic heterozygous model (OR = 1.21, 95%CI: 1.04-1.42, P = 0.02) and dominant model (OR = 1.27, 95%CI: 1.02-1.60, P = 0.04) in Caucasians populations. Conclusion: The results from this meta-analysis suggest that the XRCC1 Arg399Gln variants (Arg/Gln and Arg/Arg+Arg/Gln) may contribute to high HNC risk among Caucasians. Further well-designed studies and larger sample sizes are needed to validate our findings.

scholarly journals Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer

DNA Repair ◽  
2010 ◽  
Vol 9 (5) ◽  
pp. 558-566 ◽  
Author(s):  
Zhengdong Zhang ◽  
Luo Wang ◽  
Sheng Wei ◽  
Zhensheng Liu ◽  
Li-E. Wang ◽  
...  
Keyword(s):  
Dna Repair ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Repair Gene ◽  
Dna Repair Gene

DNA Repair Gene Polymorphisms at XRCC1 (Arg194Trp, Arg280His, and Arg399Gln) in a Healthy Tunisian Population: Interethnic Variation and Functional Prediction

2012 ◽  
Vol 16 (10) ◽  
pp. 1218-1225 ◽  
Author(s):  
Ghada Ben Salah ◽  
Imen Ayadi ◽  
Nourhene Fendri-Kriaa ◽  
Fakhri Kallabi ◽  
Emna Mkaouar-Rebai ◽  
...  
Keyword(s):  
Dna Repair ◽  
Gene Polymorphisms ◽  
Tunisian Population ◽  
Functional Prediction ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Xrcc1 Arg194trp

Abstract 5546: Impact of DNA repair and apoptosis gene polymorphisms on clinical outcome in head and neck cancer patients treated with radiotherapy

2014 ◽  
Author(s):  
Marie-Christine Etienne-Grimaldi ◽  
Delphine Borchiellini ◽  
Laurence LLorca ◽  
Jean-Louis Formento ◽  
Patricia Formento ◽  
...  
Keyword(s):  
Dna Repair ◽  
Head And Neck Cancer ◽  
Clinical Outcome ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Gene Polymorphisms ◽  
Apoptosis Gene

An interethnic variability and a functional prediction of DNA repair gene polymorphisms: the example of XRCC3 (p.Thr241>Met) and XPD (p.Lys751>Gln) in a healthy Tunisian population

2012 ◽  
Vol 39 (10) ◽  
pp. 9639-9647 ◽  
Author(s):  
Ghada Ben Salah ◽  
Nourhene Fendri-Kriaa ◽  
Hassen Kamoun ◽  
Fakhri Kallabi ◽  
Emna Mkaouar-Rebai ◽  
...  
Keyword(s):  
Dna Repair ◽  
Gene Polymorphisms ◽  
Tunisian Population ◽  
Functional Prediction ◽  
Repair Gene ◽  
Dna Repair Gene
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