DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome

2012 ◽  
Vol 36 (2) ◽  
pp. 183-189 ◽  
Author(s):  
Stuart G. Reeves ◽  
Cliff Meldrum ◽  
Claire Groombridge ◽  
Allan Spigelman ◽  
Janina Suchy ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Lynch Syndrome ◽  
Early Onset ◽  
Gene Polymorphisms ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Early Onset Colorectal Cancer

MS-920: DNA repair gene polymorphisms, diet and colorectal cancer risk in Taiwan

2005 ◽  
Vol 224 (2) ◽  
pp. 279-288 ◽  
Author(s):  
Chih-Ching Yeh ◽  
Ling-Ling Hsieh ◽  
Reiping Tang ◽  
Chung Rong Chang-Chieh ◽  
Fung-Chang Sung
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Colorectal Cancer Risk ◽  
Repair Gene ◽  
Dna Repair Gene

scholarly journals Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer

Mutagenesis ◽  
2012 ◽  
Vol 27 (2) ◽  
pp. 219-223 ◽  
Author(s):  
Ian P. M. Tomlinson ◽  
Richard S. Houlston ◽  
Grant W. Montgomery ◽  
Oliver M. Sieber ◽  
Malcolm G. Dunlop
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Gene Polymorphisms ◽  
Repair Gene ◽  
Dna Repair Gene

Association of DNA repair gene polymorphisms with colorectal cancer risk and treatment outcomes

2020 ◽  
Vol 113 ◽  
pp. 104364
Author(s):  
Fawaz N. Al-Shaheri ◽  
Kamal M. Al-Shami ◽  
Eshrak H. Gamal ◽  
Amjad A. Mahasneh ◽  
Nehad M. Ayoub
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Treatment Outcomes ◽  
Gene Polymorphisms ◽  
Colorectal Cancer Risk ◽  
Repair Gene ◽  
Dna Repair Gene

Patients with Systemic Sclerosis Present Increased DNA Damage Differentially Associated with DNA Repair Gene Polymorphisms

2014 ◽  
Vol 41 (3) ◽  
pp. 458-465 ◽  
Author(s):  
Gustavo Martelli Palomino ◽  
Carmen L. Bassi ◽  
Isabela J. Wastowski ◽  
Danilo J. Xavier ◽  
Yara M. Lucisano-Valim ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Systemic Sclerosis ◽  
Blood Cells ◽  
Gene Polymorphisms ◽  
Peripheral Blood Cells ◽  
Dna Repair Genes ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Repair Genes

Objective.Patients with systemic sclerosis (SSc) exhibit increased toxicity when exposed to genotoxic agents. In our study, we evaluated DNA damage and polymorphic sites in 2 DNA repair genes (XRCC1Arg399Gln andXRCC4Ile401Thr) in patients with SSc.Methods.A total of 177 patients were studied for DNA repair gene polymorphisms. Fifty-six of them were also evaluated for DNA damage in peripheral blood cells using the comet assay.Results.Compared to controls, the patients as a whole or stratified into major clinical variants (limited or diffuse skin involvement), irrespective of the underlying treatment schedule, exhibited increased DNA damage.XRCC1(rs: 25487) andXRCC4(rs: 28360135) allele and genotype frequencies observed in patients with SSc were not significantly different from those observed in controls; however, theXRCC1Arg399Gln allele was associated with increased DNA damage only in healthy controls and theXRCC4Ile401Thr allele was associated with increased DNA damage in both patients and controls. Further, theXRCC1Arg399Gln allele was associated with the presence of antinuclear antibody and anticentromere antibody. No association was observed between these DNA repair gene polymorphic sites and clinical features of patients with SSc.Conclusion.These results corroborate the presence of genomic instability in SSc peripheral blood cells, as evaluated by increased DNA damage, and show that polymorphic sites of theXRCC1andXRCC4DNA repair genes may differentially influence DNA damage and the development of autoantibodies.

Association of XRCC1 and OGG1 DNA repair gene polymorphisms with rheumatoid arthritis in Egyptian patients

Gene ◽  
2016 ◽  
Vol 578 (1) ◽  
pp. 112-116 ◽  
Author(s):  
Randa H. Mohamed ◽  
Amal S. El-Shal ◽  
Eman E. El-Shahawy ◽  
Sahar M. Abdel Galil
Keyword(s):  
Rheumatoid Arthritis ◽  
Dna Repair ◽  
Gene Polymorphisms ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Egyptian Patients

scholarly journals Are SNP-Smoking Association Studies Needed in Controls? DNA Repair Gene Polymorphisms and Smoking Intensity

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0129374 ◽  
Author(s):  
Zoraida Verde ◽  
Luis Reinoso ◽  
Luis Miguel Chicharro ◽  
Pilar Resano ◽  
Ignacio Sánchez-Hernández ◽  
...  
Keyword(s):  
Dna Repair ◽  
Gene Polymorphisms ◽  
Association Studies ◽  
Repair Gene ◽  
Smoking Intensity ◽  
Dna Repair Gene
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