Regulated Drug Release Abilities of Calcium Carbonate-Gelatin Hybrid Nanocarriers Fabricated via a Self-Organizational Process

ChemMedChem ◽  
2017 ◽  
Vol 12 (19) ◽  
pp. 1595-1599 ◽  
Author(s):  
Kazuki Murai ◽  
Kazuya Kurumisawa ◽  
Yoshihiro Nomura ◽  
Mutsuyoshi Matsumoto
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Organizational Process

scholarly journals Cover Feature: Regulated Drug Release Abilities of Calcium Carbonate-Gelatin Hybrid Nanocarriers Fabricated via a Self-Organizational Process (ChemMedChem 19/2017)

ChemMedChem ◽  
2017 ◽  
Vol 12 (19) ◽  
pp. 1573-1573
Author(s):  
Kazuki Murai ◽  
Kazuya Kurumisawa ◽  
Yoshihiro Nomura ◽  
Mutsuyoshi Matsumoto
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Organizational Process

scholarly journals Formulation, Development and Evaluation of Chewable Bi-layered Tablets for Treating Gastro Esophageal Reflux Disease

2020 ◽  
Vol 10 (4-s) ◽  
pp. 92-99
Author(s):  
Ankur Vasoya ◽  
Sunil Kumar Shah ◽  
C K Tyagi ◽  
Prabhakar Budholiya ◽  
Harish Pandey
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Sodium Bicarbonate ◽  
Sodium Alginate ◽  
Acid Neutralization ◽  
In Vitro Drug Release ◽  
Neutralization Capacity ◽  
Acid Neutralization Capacity ◽  
Bilayer Tablets

The purpose of this research work was to formulate raft-forming chewable bilayer tablets of sodium alginate using a raft-forming agent along with gas-generating agents. Tablets were prepared by wet granulation and evaluated for raft strength, acid neutralization capacity, weight variation, % drug content, thickness, hardness, friability and in vitro drug release. Various raft-forming agents were used in preliminary screening. The amount of sodium alginate, amount of calcium carbonate and amount sodium bicarbonate were selected as variables. Raft strength, acid neutralization capacity and drug release at 30 min were selected as responses.Tablets containing sodium alginate were having maximum raft strength as compared with other raft-forming agents. Acid neutralization capacity and in vitro drug release of all factorial batches were found to be satisfactory. Prepared tablets were found to be pharmaceutically equivalent to the marketed product. It was concluded that raft-forming chewable bilayer tablets prepared using an optimum amount of sodium alginate, calcium carbonate and sodium bicarbonate could be an efficient dosage form in the treatment of gastro oesophageal reflux diseases. Keywords: Chewable bilayer tablet, Sodium alginate, Raft forming agent, Acid Neutralizing capacity

Combine Drug Delivery of Thymoquinone-Doxorubicin by Cockle Shellderived pH-sensitive Aragonite CaCO3 Nanoparticles

2020 ◽  
Vol 10 (4) ◽  
pp. 518-533 ◽  
Author(s):  
Kehinde M. Ibiyeye ◽  
Abu B.Z. Zuki ◽  
Norshariza Nurdin ◽  
Mokrish Ajat
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Calcium Carbonate ◽  
Drug Release ◽  
Release Kinetics ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Multiple Drug ◽  
Burst Release ◽  
Cockle Shell

Background: Cockleshell-derived aragonite calcium carbonate nanoparticles were prepared by the top-down approach for combine delivery of two types of drugs. Objective: The aim of this study was to synthesize and characterize thymoquinone-doxorubicin loaded cockle shell-derived aragonite calcium carbonate nanoparticle. Aragonite calcium carbonate nanoparticles encapsulating thymoquinone and doxorubicin alone were also prepared. Methods: The blank and drug-loaded nanoparticles were characterized by field emission scanning electron microscopy, transmission electron microscopy, Zeta potential, Fourier transformed infrared and X-ray diffraction. Drug delivery properties, in vitro drug release study at pH 7.4, 6 and 4.8, and effect of blank nanoparticles on MCF10A, 3T3, MDA MB231 cells were also analyzed. Results: The blank and drug-loaded nanoparticles were pleomorphic and their sizes varying from 53.65 ± 10.29 nm to 60.49 ± 11.36 nm with an overall negative charge. The entrapment efficiency of thymoquinone and doxorubicin were 41.6 and 95.8, respectively. The FTIR showed little alteration after loading thymoquinone and doxorubicin while XRD patterns revealed no changes in the crystallizations of nanoparticles after drug loading. The drug release kinetics of doxorubicin and thymoquinone from the nanoparticles showed a continuous and gradual release after an initial burst release was observed. At pH 4.8, about 100% of drug release was noticed, 70% at pH 6 while only 50% at pH 7.4. The cell viability was 80% at a concentration of 1000 ug/ml of blank nanoparticle. Conclusion: The cockle shell-derived pH sensitive aragonite calcium carbonate nanoparticle provides an effective and simple means of multiple drug delivery and function as a platform for pH controlled release of loaded therapeutic agents.

scholarly journals Correction: Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration

2020 ◽  
Vol 56 (73) ◽  
pp. 10768-10769
Author(s):  
Cheng Wang ◽  
Xuerong Liu ◽  
Shaoqing Chen ◽  
Fuqiang Hu ◽  
Jihong Sun ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Hybrid Nanoparticles ◽  
Amorphous Calcium Carbonate ◽  
Tumor Penetration ◽  
Facile Preparation

Correction for ‘Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration’ by Cheng Wang et al., Chem. Commun., 2018, 54, 13080–13083, DOI: 10.1039/C8CC07694D.

A fast and simple method for preparation of calcium carbonate–drug composites for fast drug release

2013 ◽  
Vol 48 (1) ◽  
pp. 137-145 ◽  
Author(s):  
Uroš Maver ◽  
Marjan Bele ◽  
Janez Jamnik ◽  
Miran Gaberšček ◽  
Odon Planinšek
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Simple Method

scholarly journals FORMULATION AND EVALUATION OF FLOATING IN SITU GEL OF CIPROFLOXACIN

2019 ◽  
Vol 11 (1) ◽  
pp. 198
Author(s):  
Shailaja Pashikanti ◽  
Jyothsna B.
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Sodium Alginate ◽  
Gelling Agent ◽  
In Vitro Drug Release ◽  
In Situ Gel ◽  
Degradable Polymer ◽  
Gel Formulations

Objective: The objective of the study was to develop floating in situ gel formulations of Ciprofloxacin that has a narrow absorption window and mainly absorbed in the proximal areas of GIT. These formulations increases the targeted action on bacteria for a longer time that can be used in the treatment of Helicobacter pylori (H. pylori) infections and urinary tract infections.Methods: In situ gel formulations were prepared by varying concentrations of sodium alginate as in situ gel forming bio-degradable polymer and calcium carbonate as a cross-linking agent. The formulations were evaluated for Physical appearance, pH, in vitro drug release, viscosity, in vitro floating behaviour, in vitro gelling capacity and drug content. FTIR was conducted for Ciprofloxacin, excipients used and optimized formulation.Results: All the formulations showed an optimum viscosity that will allow ease of administration and swallowing. Floating lag time of all formulations was between 32-70 seconds and floated for>12 h. The in vitro gelling capacity increased with increasing the polymer and gelling agent concentrations. Increase in polymer concentration decreased the rate and extent of the drug release. Among all the formulations, F4 containing 4% w/v of sodium alginate and 4% w/v of calcium carbonate showed sustained in vitro drug release (95.6%) over an extended period of 12 h. FTIR studies revealed no interaction between drug and excipients used. Drug release from the formulations followed First order kinetics with Fickian diffusion.Conclusion: Ciprofloxacin was successfully formulated as a pH-triggered floating in situ gelling system using sodium alginate.

scholarly journals Correction: Taking advantage of the disadvantage: employing the high aqueous instability of amorphous calcium carbonate to realize burst drug release within cancer cells

2020 ◽  
Vol 8 (33) ◽  
pp. 7558-7558
Author(s):  
Cheng Wang ◽  
Shaoqing Chen ◽  
Qin Yu ◽  
Fuqiang Hu ◽  
Hong Yuan
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Cancer Cells ◽  
Amorphous Calcium Carbonate

Correction for ‘Taking advantage of the disadvantage: employing the high aqueous instability of amorphous calcium carbonate to realize burst drug release within cancer cells’ by Cheng Wang et al., J. Mater. Chem. B, 2017, 5, 2068–2073, DOI: 10.1039/C6TB02826H.

Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration

2018 ◽  
Vol 54 (93) ◽  
pp. 13080-13083 ◽  
Author(s):  
Cheng Wang ◽  
Xuerong Liu ◽  
Shaoqing Chen ◽  
Fuqiang Hu ◽  
Jihong Sun ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Hybrid System ◽  
Hybrid Nanoparticles ◽  
Drug Penetration ◽  
Amorphous Calcium Carbonate ◽  
Tumor Penetration ◽  
Tumor Tissues ◽  
Facile Preparation

A hybrid system able to specifically realize water-responsive burst drug release and potentiate drug penetration into deep tumor tissues has been developed.

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