scholarly journals Correction: Taking advantage of the disadvantage: employing the high aqueous instability of amorphous calcium carbonate to realize burst drug release within cancer cells

2020 ◽  
Vol 8 (33) ◽  
pp. 7558-7558
Author(s):  
Cheng Wang ◽  
Shaoqing Chen ◽  
Qin Yu ◽  
Fuqiang Hu ◽  
Hong Yuan
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Cancer Cells ◽  
Amorphous Calcium Carbonate

Correction for ‘Taking advantage of the disadvantage: employing the high aqueous instability of amorphous calcium carbonate to realize burst drug release within cancer cells’ by Cheng Wang et al., J. Mater. Chem. B, 2017, 5, 2068–2073, DOI: 10.1039/C6TB02826H.

Taking advantage of the disadvantage: employing the high aqueous instability of amorphous calcium carbonate to realize burst drug release within cancer cells

2017 ◽  
Vol 5 (11) ◽  
pp. 2068-2073 ◽  
Author(s):  
Cheng Wang ◽  
Shaoqing Chen ◽  
Qin Yu ◽  
Fuqiang Hu ◽  
Hong Yuan
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Cancer Cells ◽  
Major Obstacle ◽  
Burst Release ◽  
Amorphous Calcium Carbonate

The high aqueous instability of amorphous calcium carbonate (ACC), which will lead to a burst release of its payload, has generally been recognized as the major obstacle for its further application in nanomedicine.

scholarly journals Correction: Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration

2020 ◽  
Vol 56 (73) ◽  
pp. 10768-10769
Author(s):  
Cheng Wang ◽  
Xuerong Liu ◽  
Shaoqing Chen ◽  
Fuqiang Hu ◽  
Jihong Sun ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Hybrid Nanoparticles ◽  
Amorphous Calcium Carbonate ◽  
Tumor Penetration ◽  
Facile Preparation

Correction for ‘Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration’ by Cheng Wang et al., Chem. Commun., 2018, 54, 13080–13083, DOI: 10.1039/C8CC07694D.

Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration

2018 ◽  
Vol 54 (93) ◽  
pp. 13080-13083 ◽  
Author(s):  
Cheng Wang ◽  
Xuerong Liu ◽  
Shaoqing Chen ◽  
Fuqiang Hu ◽  
Jihong Sun ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Hybrid System ◽  
Hybrid Nanoparticles ◽  
Drug Penetration ◽  
Amorphous Calcium Carbonate ◽  
Tumor Penetration ◽  
Tumor Tissues ◽  
Facile Preparation

A hybrid system able to specifically realize water-responsive burst drug release and potentiate drug penetration into deep tumor tissues has been developed.

The Improvement of Paclitaxel Cytotoxicity using Nanocellulose based Nature Resources

2019 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
R Nahrowi ◽  
A Setiawan ◽  
Noviany Noviany ◽  
I Sukmana ◽  
S D Yuwono
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Natural Resources ◽  
Cell Viability ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Target Cell ◽  
Mitotic Cycle ◽  
Potential Sources ◽  
Local Accumulation

Paclitaxel is one of the cancer drugs that often used. These drug kills cancer cells byinhibiting mitotic cycle. The efficiency of paclitaxel is increased by the use ofnanomaterials as a carrier of paclitaxel. Nanomaterials can enhance encapsulationefficiency, improve the drug release to the target cell following nanomaterialdegradation, and improve local accumulation of drug in the cell through endocytosisreceptor. Nanomaterial that often used forencapsulation of paclitaxel is a polymerderived from natural resources such as cellulose. The advantages of cellulose as acarrier of paclitaxel are nontoxic, biodegradable, and very abundant from varioussources. One of the potential sources of cellulose for drug delivery system is cassavabaggase.Keywords: Paclitaxel, encapsulation, cell viability, nanocellulose

scholarly journals Pure hydroxyapatite synthesis originating from amorphous calcium carbonate

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michika Sawada ◽  
Kandi Sridhar ◽  
Yasuharu Kanda ◽  
Shinya Yamanaka
Keyword(s):  
Calcium Carbonate ◽  
Calcium Phosphate ◽  
Room Temperature ◽  
Molar Ratio ◽  
Final Phase ◽  
Amorphous Calcium Carbonate ◽  
Phosphate Compound ◽  
Synthesis Strategy ◽  
Phosphorylation Reaction ◽  
Subsequent Calcination

AbstractWe report a synthesis strategy for pure hydroxyapatite (HAp) using an amorphous calcium carbonate (ACC) colloid as the starting source. Room-temperature phosphorylation and subsequent calcination produce pure HAp via intermediate amorphous calcium phosphate (ACP). The pre-calcined sample undergoes a competitive transformation from ACC to ACP and crystalline calcium carbonate. The water content, ACC concentration, Ca/P molar ratio, and pH during the phosphorylation reaction play crucial roles in the final phase of the crystalline phosphate compound. Pure HAp is formed after ACP is transformed from ACC at a low concentration (1 wt%) of ACC colloid (1.71 < Ca/P < 1.88), whereas Ca/P = 1.51 leads to pure β-tricalcium phosphate. The ACP phases are precursors for calcium phosphate compounds and may determine the final crystalline phase.

scholarly journals Photo-Responsive Supramolecular Micelles for Controlled Drug Release and Improved Chemotherapy

2020 ◽  
Vol 22 (1) ◽  
pp. 154
Author(s):  
Fasih Bintang Ilhami ◽  
Kai-Chen Peng ◽  
Yi-Shiuan Chang ◽  
Yihalem Abebe Alemayehu ◽  
Hsieh-Chih Tsai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Visible Light ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Reactive Oxygen ◽  
Controlled Drug Release ◽  
Grand Challenge ◽  
Supramolecular System ◽  
Oxygen Species

Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular micelles (A-PPG), in order to achieve effective drug delivery combined with photo-chemotherapy. The resulting DOX/5-ALA-loaded micelles exhibited excellent light and pH-responsive behavior in aqueous solution and high drug-entrapment stability in serum-rich media. A short duration (1–2 min) of laser irradiation with visible light induced the dissociation of the DOX/5-ALA complexes within the micelles, which disrupted micellular stability and resulted in rapid, immediate release of the physically entrapped drug from the micelles. In addition, in vitro assays of cellular reactive oxygen species generation and cellular internalization confirmed the drug-loaded micelles exhibited significantly enhanced cellular uptake after visible light irradiation, and that the light-triggered disassembly of micellar structures rapidly increased the production of reactive oxygen species within the cells. Importantly, flow cytometric analysis demonstrated that laser irradiation of cancer cells incubated with DOX/5-ALA-loaded A-PPG micelles effectively induced apoptotic cell death via endocytosis. Thus, this newly developed supramolecular system may offer a potential route towards improving the efficacy of synergistic chemotherapeutic approaches for cancer.

Controllable assembly/disassembly of polyphenol-DNA nanocomplex for cascade-responsive drug release in cancer cells

Biomaterials ◽  
2021 ◽  
Vol 273 ◽  
pp. 120846
Author(s):  
Jinpeng Han ◽  
Yuchen Cui ◽  
Zi Gu ◽  
Dayong Yang
Keyword(s):  
Drug Release ◽  
Cancer Cells

scholarly journals Cholesterol Levels Affect the Performance of AuNPs-Decorated Thermo-Sensitive Liposomes as Nanocarriers for Controlled Doxorubicin Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 973
Author(s):  
Mónica C. García ◽  
Nabila Naitlho ◽  
José Manuel Calderón-Montaño ◽  
Estrella Drago ◽  
Manuela Rueda ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Electrostatic Interactions ◽  
Drug Loading ◽  
Gradient Methods ◽  
Spherical Shape ◽  
Morphological Properties ◽  
Ovarian Cancer Cells ◽  
Cholesterol Levels ◽  
L1 And L2

Stimulus-responsive liposomes (L) for triggering drug release to the target site are particularly useful in cancer therapy. This research was focused on the evaluation of the effects of cholesterol levels in the performance of gold nanoparticles (AuNPs)-functionalized L for controlled doxorubicin (D) delivery. Their interfacial and morphological properties, drug release behavior against temperature changes and cytotoxic activity against breast and ovarian cancer cells were studied. Langmuir isotherms were performed to identify the most stable combination of lipid components. Two mole fractions of cholesterol (3.35 mol% and 40 mol%, L1 and L2 series, respectively) were evaluated. Thin-film hydration and transmembrane pH-gradient methods were used for preparing the L and for D loading, respectively. The cationic surface of L allowed the anchoring of negatively charged AuNPs by electrostatic interactions, even inducing a shift in the zeta potential of the L2 series. L exhibited nanometric sizes and spherical shape. The higher the proportion of cholesterol, the higher the drug loading. D was released in a controlled manner by diffusion-controlled mechanisms, and the proportions of cholesterol and temperature of release media influenced its release profiles. D-encapsulated L preserved its antiproliferative activity against cancer cells. The developed liposomal formulations exhibit promising properties for cancer treatment and potential for hyperthermia therapy.

A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy

2015 ◽  
Vol 51 (46) ◽  
pp. 9567-9570 ◽  
Author(s):  
Peilian Liu ◽  
Jiangsheng Xu ◽  
Donghang Yan ◽  
Peisheng Zhang ◽  
Fang Zeng ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Dt Diaphorase

A DT-diaphorase responsive theranostic prodrug has been developed for diagnosis, tracking of drug release and selectively killing cancer cells over-expressed with DT-diaphorase.

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