scholarly journals Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor

2017 ◽  
Vol 15 (21) ◽  
pp. 4704-4710 ◽  
Author(s):  
Salvatore Pacifico ◽  
Aidan Kerckhoffs ◽  
Andrew J. Fallow ◽  
Rachel E. Foreman ◽  
Remo Guerrini ◽  
...  
Keyword(s):  
G Protein ◽  
Disulfide Bond ◽  
Covalent Binding ◽  
Urotensin Ii ◽  
Binding Mechanism ◽  
G Protein Coupled Receptor ◽  
High Affinity ◽  
G Protein Coupled ◽  
Insight Into

New high affinity peptidomimetic ligands have been developed that provided new insight into the mechanism of binding of U-II peptide with the urotensin-II receptor.

scholarly journals A Structural Insight into the Reorientation of Transmembrane Domains 3 and 5 during Family A G Protein-Coupled Receptor Activation

2010 ◽  
Vol 79 (2) ◽  
pp. 262-269 ◽  
Author(s):  
Kamonchanok Sansuk ◽  
Xavier Deupi ◽  
Ivan R. Torrecillas ◽  
Aldo Jongejan ◽  
Saskia Nijmeijer ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Activation ◽  
Transmembrane Domains ◽  
G Protein Coupled Receptor ◽  
Structural Insight ◽  
G Protein Coupled ◽  
Insight Into

Molecular basis of G protein-coupled receptor high affinity for gastrin-releasing peptide (GRP)

2003 ◽  
Vol 124 (4) ◽  
pp. A469
Author(s):  
Tomoo Nakagawa ◽  
Jose A. Tapia ◽  
Kenji Tokita ◽  
Samuel Mantey ◽  
Michael Schumann ◽  
...  
Keyword(s):  
G Protein ◽  
Molecular Basis ◽  
G Protein Coupled Receptor ◽  
Gastrin Releasing Peptide ◽  
High Affinity ◽  
G Protein Coupled

Predicted Ligands for the Human Urotensin-II G Protein-Coupled Receptor with Some Experimental Validation

ChemMedChem ◽  
2014 ◽  
pp. n/a-n/a
Author(s):  
Soo-Kyung Kim ◽  
William A. Goddard ◽  
Kyu Yang Yi ◽  
Byung Ho Lee ◽  
Chae Jo Lim ◽  
...  
Keyword(s):  
G Protein ◽  
Experimental Validation ◽  
Urotensin Ii ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

A novel role of G protein-coupled receptor kinase 5 in urotensin II-stimulated cellular hypertrophy in H9c2UT cells

2016 ◽  
Vol 422 (1-2) ◽  
pp. 151-160 ◽  
Author(s):  
Cheon Ho Park ◽  
Ju Hee Lee ◽  
Mi Young Lee ◽  
Jeong Hyun Lee ◽  
Byung Ho Lee ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
Urotensin Ii ◽  
G Protein Coupled Receptor ◽  
Cellular Hypertrophy ◽  
G Protein Coupled
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