Simultaneous chiral separation of tramadol and methadone in tablets, human urine, and plasma by capillary electrophoresis using maltodextrin as the chiral selector

Chirality ◽  
2018 ◽  
Vol 30 (10) ◽  
pp. 1161-1168 ◽  
Author(s):  
Elahe Naghdi ◽  
Ali Reza Fakhari
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation ◽  
Human Urine ◽  
Chiral Selector

scholarly journals Enantioseparation and Determination of Mephedrone and Its Metabolites by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2879
Author(s):  
Pavel Řezanka ◽  
Denisa Macková ◽  
Radek Jurok ◽  
Michal Himl ◽  
Martin Kuchař
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation ◽  
Simplex Method ◽  
Background Electrolyte ◽  
Detection Limits ◽  
Chiral Selector ◽  
Designer Drug ◽  
Optimal Composition ◽  
Linear Calibration

Mephedrone, a psychoactive compound derived from cathinone, is widely used as a designer drug. The determination of mephedrone and its metabolites is important for understanding its possible use in medicine. In this work, a method of capillary electrophoresis for the chiral separation of mephedrone and its metabolites was developed. Carboxymethylated β-cyclodextrin was selected as the most effective chiral selector from seven tested cyclodextrin derivates. Based on the simplex method, the optimal composition of the background electrolyte was determined: at pH 2.75 and 7.5 mmol·L−1 carboxymethylated β-cyclodextrin the highest total resolution of a mixture of analytes was achieved. For mephedrone and its metabolites, calibration curves were constructed in a calibration range from 0.2 to 5 mmol·L−1; limits of detection, limits of quantification, precision, and repeatability were calculated, and according to Mandel’s fitting test, the linear calibration ranges were determined.

Determination of terbutaline enantiomers in human urine by capillary electrophoresis using hydroxypropyl-β-cyclodextrin as a chiral selector

2003 ◽  
Vol 26 (2) ◽  
pp. 120-123 ◽  
Author(s):  
Kim Kyeong Ho ◽  
Seo Sang Hun ◽  
Kim Hyun Ju ◽  
Jeun Eun Young ◽  
Kang Jong-Seong ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Human Urine ◽  
Chiral Selector

Chiral separation of β2-agonists by capillary electrophoresis using hydroxypropyl-α-cyclodextrin as a chiral selector

2001 ◽  
Vol 24 (4) ◽  
pp. 281-285 ◽  
Author(s):  
Kyeong Ho Kim ◽  
Hyun Ju Kim ◽  
Eun Young Jeun ◽  
Sang Hun Seo ◽  
Seon-Pyo Hong ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation ◽  
Chiral Selector ◽  
Β2 Agonists
Sign in / Sign up

Export Citation Format

Share Document