Chiral Separation of Uncharged Pomalidomide Enantiomers Using Carboxymethyl-β-Cyclodextrin: A Validated Capillary Electrophoretic Method

Chirality ◽  
2015 ◽  
Vol 28 (3) ◽  
pp. 199-203 ◽  
Author(s):  
Zoltán-István Szabó ◽  
Levente Szőcs ◽  
Daniela-Lucia Muntean ◽  
Béla NoszáL ◽  
Gergő Tóth
Keyword(s):  
Chiral Separation ◽  
Electrophoretic Method ◽  
Capillary Electrophoretic

scholarly journals Molecular Modeling and Chiral Separation of Benzodiazepines by Capillary Electrophoresis Using Highly Sulfated Cyclodextrins

2018 ◽  
Vol 62 (2) ◽  
Author(s):  
María Gabriela Vargas Martinez ◽  
Guillermo Ramírez Galicia
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation ◽  
Theoretical Study ◽  
Equilibrium Constants ◽  
Fractional Factorial ◽  
Organic Modifier ◽  
Enantiomeric Resolution ◽  
Electrophoretic Method ◽  
Capillary Electrophoretic ◽  
Separation Conditions

<p>A capillary electrophoretic method for the chiral separation of the 3-chiral-1,4-benzodiazepines was developed. Enantiomeric resolution of oxazepam, lorazepam, temazepam, and lormetazepam was achieved using sulfated cyclodextrins (CD's) as chiral selectors. A 3-levels, 4-factors fractional factorial (34-2) design was applied to test 3 different CD's: heptakis-6-sulfato--cyclodextrin (HSCD), heptakis-(2,3-diacetyl-6-sulfato)--cyclodextrin (HDASCD), and heptakis-(2,3-dimethyl-6-sulfato)--cyclodextrin (HDMSCD). The CD type, its concentration, the pH of the electrolyte, and % organic modifier were tested as the factors in the experimental design. The highest resolution values were obtained using a 20 mM borate buffer, pH 9.0 with the addition of 5 % HSCD and 15 % methanol as an organic modifier. At these separation conditions, the equilibrium constants of the benzodiazepine-HSCD complex formation were calculated. A theoretical study of the interaction benzodiazepine-HSCD complex using semiempirical calculations is postulated.</p>

Capillary electrophoretic chiral separation of hydroxychloroquine and its metabolites in the microsomal fraction of liver homogenates

2006 ◽  
Vol 27 (5-6) ◽  
pp. 1248-1254 ◽  
Author(s):  
Carmem Dickow Cardoso ◽  
Valquíria A. Polisel Jabor ◽  
Pierina Sueli Bonato
Keyword(s):  
Chiral Separation ◽  
Microsomal Fraction ◽  
Capillary Electrophoretic ◽  
Liver Homogenates

Capillary electrophoretic method for the determination of diterpenoid isomers in Acanthopanax species

2006 ◽  
Vol 40 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Nguyen Thi Phuong ◽  
Kyung Ah Lee ◽  
Su Jin Jeong ◽  
Cai Xing Fu ◽  
Jung Kap Choi ◽  
...  
Keyword(s):  
Electrophoretic Method ◽  
Capillary Electrophoretic ◽  
Acanthopanax Species
Sign in / Sign up

Export Citation Format

Share Document