ChemInform Abstract: The Uniqueness and Therapeutic Value of Natural Products from West African Medicinal Plants. Part 2. Terpenoids, Geographical Distribution and Drug Discovery

ChemInform ◽  
2014 ◽  
Vol 45 (47) ◽  
pp. no-no
Author(s):  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Conrad V. Simoben ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Medicinal Plants ◽  
Geographical Distribution ◽  
West African ◽  
Therapeutic Value

The uniqueness and therapeutic value of natural products from West African medicinal plants, part II: terpenoids, geographical distribution and drug discovery

RSC Advances ◽  
2014 ◽  
Vol 4 (67) ◽  
pp. 35348-35370 ◽  
Author(s):  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Conrad V. Simoben ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Medicinal Plants ◽  
Geographical Distribution ◽  
Biological Activities ◽  
West African ◽  
Therapeutic Value

In this review series, an attempt has been made to give indepth coverage of natural products derived from West African medicinal plants with diverse biological activities.

The uniqueness and therapeutic value of natural products from West African medicinal plants, part III: least abundant compound classes

RSC Advances ◽  
2014 ◽  
Vol 4 (75) ◽  
pp. 40095-40110 ◽  
Author(s):  
Conrad V. Simoben ◽  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Biological Activities ◽  
West African ◽  
Therapeutic Value

In this review, a continuation of our in-depth coverage of natural products derived from West African medicinal plants with diverse biological activities has been given.

The uniqueness and therapeutic value of natural products from West African medicinal plants. Part I: uniqueness and chemotaxonomy

RSC Advances ◽  
2014 ◽  
Vol 4 (54) ◽  
pp. 28728-28755 ◽  
Author(s):  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Conrad V. Simoben ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Biological Activities ◽  
West African ◽  
Therapeutic Value

This review gives an in depth coverage of the natural products derived from West African medicinal plants with diverse biological activities.

ChemInform Abstract: The Uniqueness and Therapeutic Value of Natural Products from West African Medicinal Plants. Part 3. Least Abundant Compound Classes

ChemInform ◽  
2014 ◽  
Vol 45 (49) ◽  
pp. no-no
Author(s):  
Conrad V. Simoben ◽  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
West African ◽  
Therapeutic Value

ChemInform Abstract: The Uniqueness and Therapeutic Value of Natural Products from West African Medicinal Plants. Part 1. Uniqueness and Chemotaxonomy

ChemInform ◽  
2014 ◽  
Vol 45 (46) ◽  
pp. no-no
Author(s):  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Conrad V. Simoben ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
West African ◽  
Therapeutic Value

scholarly journals COVID-19: General Strategies for Herbal Therapies

2022 ◽  
Vol 27 ◽  
pp. 2515690X2110536
Author(s):  
Samaneh Soleymani ◽  
Ayeh Naghizadeh ◽  
Mehrdad Karimi ◽  
Azadeh Zarei ◽  
Raefeh Mardi ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Medicinal Plants ◽  
Nigella Sativa ◽  
Management Strategies ◽  
Future Research ◽  
Virus Binding ◽  
New Drug ◽  
Prevention And Treatment ◽  
Ammoides Verticillata

The coronavirus disease-2019 (COVID-19) pandemic started in early 2020 with the outbreak of a highly pathogenic human coronavirus. The world is facing a challenge and there is a pressing need for efficient drugs. Plants and natural compounds are a proven rich resource for new drug discovery. Considering the potential of natural products to manage the pandemic, this article was designed to provide an inclusive map of the stages and pathogenetic mechanisms for effective natural products on COVID-19. New drug discovery for the COVID-19 pandemic can encompass both prevention and disease management strategies. Preventive mechanisms that may be considered include boosting the immune response and hand hygiene in the preexposure phase; and blocking of virus binding and entry in the postexposure phase. Potential therapeutic target mechanisms include virus-directed therapies and host-directed therapies. Several medicinal plants and natural products, such as Withania somnifera (L.) Dunal and propolis for prevention; Tanacetum parthenium (L.) for treatment; and Ammoides verticillata (Desf.) Briq and Nigella sativa L. for both prevention and treatment have been found effective and are good targets for future research. The examples of phytochemical compounds that may be effective include aloin and terpenes as anti-septics; isothymol, dithymoquinone, and glycyrrhizin as inhibitors of virus binding and entry; glycyrrhizin, and berberine as replication suppressants; ginsenoside Rg1 and parthenolide as immunomodulators; and eriocitrin, rhoifolin, hesperidin, naringin, rutin, and veronicastroside as anti-complements. Recognizing different mechanisms of fighting against this virus can lead to a more systematic approach in finding natural products and medicinal plants for COVID-19 prevention and treatment.

scholarly journals Brine Shrimp Lethality Bioassay: A Tool for Drug Discovery from Natural Products

2020 ◽  
Vol 1 (2) ◽  
pp. 40-48
Author(s):  
George Owusu-Dapaah ◽  
Nicolas I.Y. Fiagbe
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Brine Shrimp ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Brine Shrimp Lethality ◽  
Structure Activity

This study demonstrates the importance of the Brine Shrimp Bioassay in drug discovery. It uses two medicinal plants, Zanthoxylum xanthoxyloides and Tiliacora funifera. Extracts of Zanthoxylum xanthoxyloides were prepared using water, ethanol, chloroform and diethylether, and each subjected to Brine Shrimp Bioassay. The bioactivities of the extracts were found to be in the order diethylether (LD50=0.958 mg/ml), followed by ethanol (LD50=1.874 mg/ml), water(LD50=2.322 mg/ml), and chloroform (3.518 mg/ml). From Tiliacora funifera is isolated the compound funiferine, which is derivatized to obtain o-methylfuniferine and o-isopropylfuniferine. These were subjected to the brine shrimp bioassay, and the structure –activity relationship (SAR) was determined. The results showed that o-isopropylfuniferine is the most bioactive (LD50 = 9.07 mg/ml), followed by o-methylfuniferine (LD50 =38 mg/ml) with funiferine showing the least activity (LD50 =50.25 mg/ml). The SAR of the compounds indicates that the activity of the compounds increases as the size of the group on the phenolic OH is increased, (i.e. isopropyl (C 3 H7 )> methyl (CH3 ) > hydrogen (H)), which suggests that bulkier groups may give more potent compounds. These two results show that the brine shrimp bioassay can be used as a tool in the search for more bioactive compounds from natural products. Keywords: Brine Shrimp Bioassay, Zanthoxylum xanthoxyloides, Funiferine; o-methylfuniferine,o-isopropylfuniferine.

The chemistry and bioactivity of Southern African flora II: flavonoids, quinones and minor compound classes

RSC Advances ◽  
2015 ◽  
Vol 5 (71) ◽  
pp. 57704-57720 ◽  
Author(s):  
Smith B. Babiaka ◽  
Fidele Ntie-Kang ◽  
Bakoh Ndingkokhar ◽  
James A. Mbah ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Medicinal Plants ◽  
Biological Activities ◽  
African Flora ◽  
Minor Compound

This review is intended to highlight the relevance of natural products in drug discovery paying particular attention to those derived from Southern African medicinal plants with diverse biological activities.

In Vitro Anti-Infective Screening Of Selected West African Medicinal Plants

Planta Medica ◽  
2016 ◽  
Vol 82 (05) ◽  
Author(s):  
VO Imieje ◽  
PS Fasinu ◽  
KO Ogbeide ◽  
NO Egiebor ◽  
A Falodun
Keyword(s):  
Medicinal Plants ◽  
West African
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