The uniqueness and therapeutic value of natural products from West African medicinal plants, part II: terpenoids, geographical distribution and drug discovery

RSC Advances ◽  
2014 ◽  
Vol 4 (67) ◽  
pp. 35348-35370 ◽  
Author(s):  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Conrad V. Simoben ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Medicinal Plants ◽  
Geographical Distribution ◽  
Biological Activities ◽  
West African ◽  
Therapeutic Value

In this review series, an attempt has been made to give indepth coverage of natural products derived from West African medicinal plants with diverse biological activities.

ChemInform Abstract: The Uniqueness and Therapeutic Value of Natural Products from West African Medicinal Plants. Part 2. Terpenoids, Geographical Distribution and Drug Discovery

ChemInform ◽  
2014 ◽  
Vol 45 (47) ◽  
pp. no-no
Author(s):  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Conrad V. Simoben ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Medicinal Plants ◽  
Geographical Distribution ◽  
West African ◽  
Therapeutic Value

The uniqueness and therapeutic value of natural products from West African medicinal plants, part III: least abundant compound classes

RSC Advances ◽  
2014 ◽  
Vol 4 (75) ◽  
pp. 40095-40110 ◽  
Author(s):  
Conrad V. Simoben ◽  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Biological Activities ◽  
West African ◽  
Therapeutic Value

In this review, a continuation of our in-depth coverage of natural products derived from West African medicinal plants with diverse biological activities has been given.

The uniqueness and therapeutic value of natural products from West African medicinal plants. Part I: uniqueness and chemotaxonomy

RSC Advances ◽  
2014 ◽  
Vol 4 (54) ◽  
pp. 28728-28755 ◽  
Author(s):  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Conrad V. Simoben ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Biological Activities ◽  
West African ◽  
Therapeutic Value

This review gives an in depth coverage of the natural products derived from West African medicinal plants with diverse biological activities.

ChemInform Abstract: The Uniqueness and Therapeutic Value of Natural Products from West African Medicinal Plants. Part 3. Least Abundant Compound Classes

ChemInform ◽  
2014 ◽  
Vol 45 (49) ◽  
pp. no-no
Author(s):  
Conrad V. Simoben ◽  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
West African ◽  
Therapeutic Value

The chemistry and bioactivity of Southern African flora II: flavonoids, quinones and minor compound classes

RSC Advances ◽  
2015 ◽  
Vol 5 (71) ◽  
pp. 57704-57720 ◽  
Author(s):  
Smith B. Babiaka ◽  
Fidele Ntie-Kang ◽  
Bakoh Ndingkokhar ◽  
James A. Mbah ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Medicinal Plants ◽  
Biological Activities ◽  
African Flora ◽  
Minor Compound

This review is intended to highlight the relevance of natural products in drug discovery paying particular attention to those derived from Southern African medicinal plants with diverse biological activities.

ChemInform Abstract: The Uniqueness and Therapeutic Value of Natural Products from West African Medicinal Plants. Part 1. Uniqueness and Chemotaxonomy

ChemInform ◽  
2014 ◽  
Vol 45 (46) ◽  
pp. no-no
Author(s):  
Fidele Ntie-Kang ◽  
Lydia L. Lifongo ◽  
Conrad V. Simoben ◽  
Smith B. Babiaka ◽  
Wolfgang Sippl ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
West African ◽  
Therapeutic Value

scholarly journals Marine natural products from sponges (Porifera) of the order Dictyoceratida (2013 to 2019); a promising source for drug discovery

RSC Advances ◽  
2020 ◽  
Vol 10 (57) ◽  
pp. 34959-34976
Author(s):  
Enas Reda Abdelaleem ◽  
Mamdouh Nabil Samy ◽  
Samar Yehia Desoukey ◽  
Miaomiao Liu ◽  
Ronald J. Quinn ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Marine Natural Products ◽  
Biological Activities ◽  
Marine Organisms ◽  
Promising Source ◽  
Secondary Natural Products

Marine organisms have been considered an interesting target for the discovery of different classes of secondary natural products with wide-ranging biological activities.

scholarly journals Uncovering Novel Peptide Chemistry from Bacterial Natural Products

2021 ◽  
Vol 75 (6) ◽  
pp. 543-547
Author(s):  
Florian Hubrich ◽  
Alessandro Lotti ◽  
Thomas A. Scott ◽  
Jörn Piel
Keyword(s):  
Natural Products ◽  
Bioactive Peptides ◽  
Biological Activities ◽  
Biological Properties ◽  
Post Translational Modifications ◽  
Peptide Chemistry ◽  
Chemical Structures ◽  
Therapeutic Value ◽  
Modified Peptides ◽  
Unique Chemical

Nature has evolved a remarkable array of biosynthetic enzymes that install diverse chemistries into natural products (NPs), bestowing them with a range of important biological properties that are of considerable therapeutic value. This is epitomized by the ribosomally synthesized and post-translationally modified peptides (RiPPs), a class of peptide natural products that undergo extensive post-translational modifications to produce structurally diverse bioactive peptides. In this review, we provide an overview of our research into the proteusin RiPP family, describing characterized members and the maturation enzymes responsible for their unique chemical structures and biological activities. The diverse enzymology identified in the first two proteusin pathways highlights the enormous potential of the RiPP class for new lead structures and novel pharmacophore-installing maturases as biocatalytic tools for drug discovery efforts.

Natural Products with tandem Anti-inflammatory, Immunomodulatory and Anti-SARS-CoV/2 effects: A Drug Discovery Perspective against SARS-CoV-2

2021 ◽  
Vol 28 ◽  
Author(s):  
Luana N. O. Leal da Cunha ◽  
Tiago Tizziani ◽  
Gabriella B. Souza ◽  
Monalisa A. Moreira ◽  
José S. S. Neto ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
In Silico ◽  
Biological Activities ◽  
Cysteine Proteases ◽  
Drug Candidate ◽  
Plant Metabolites ◽  
Drug Candidates ◽  
In Silico Studies ◽  
Anti Inflammatory

Background: COVID-19 is still causing victims with long-term health consequences, mass deaths, and collapsing healthcare systems around the world. The disease has no efficient drugs. However, previous studies revealed that SARS-CoV-2 and SARS-CoV have 96% and 86.5% similarities in cysteine proteases (3CLpro) and papain-like protease (PLpro) sequences, respectively. This resemblance could be significant in the search for drug candidates with antiviral effects against SARS-CoV-2. Objective: This paper is a compilation of natural products that inhibit SARS-CoV 3CLpro and PLpro and, concomitantly, reduce inflammation and/or modulate the immune system as a perspective strategy for COVID-19 drug discovery. It also presents in silico studies performed on these selected natural products using SARS-CoV-2 3CLpro and PLpro as targets to propose a list of hit compounds. Method: The plant metabolites were selected in the literature based on their biological activities on SARS-CoV proteins, inflammatory mediators, and immune response. The consensus docking analysis was performed using four different packages. Results: Seventy-nine compounds reported in the literature with inhibitory effects on SARS-CoV proteins were reported as anti-inflammatory agents. Fourteen of them showed in previous studies immunomodulatory effects. Five and six of these compounds showed significant in silico consensus as drug candidates that can inhibit PLpro and 3CLpro, respectively. Our findings corroborated recent results reported on anti-SARS-CoV-2 in the literature. Conclusion: This study revealed that amentoflavone, rubranoside B, savinin, psoralidin, hirsutenone, and papyriflavonol A are good drug candidate for the search of antibiotics against COVID-19.

Recent investigations of bioactive natural products from endophytic, marine-derived, insect pathogenic fungi and Thai medicinal plants

2014 ◽  
Vol 86 (6) ◽  
pp. 979-993 ◽  
Author(s):  
Chulabhorn Mahidol ◽  
Prasat Kittakoop ◽  
Vilailak Prachyawarakorn ◽  
Phanruethai Pailee ◽  
Hunsa Prawat ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Biological Activities ◽  
Geographical Location ◽  
Pathogenic Fungi ◽  
Biologically Active ◽  
Bioactive Substances ◽  
Bioactive Natural Products ◽  
Insect Pathogenic Fungi ◽  
Living Organisms

AbstractLiving organisms in Thailand are very diverse due to the unique geographical location of Thailand. The diversity of Thai bioresources has proven to be a rich source of biologically active compounds. The present review covers bioactive substances from Thai endophytic, marine-derived, insect pathogenic fungi and medicinal plants. Many new compounds isolated from Thai bioresources have diverse skeletons belonging to various classes of natural products. These compounds exhibited an array of biological activities, and some are of pharmaceutical interest. Bioactive compounds from Thai bioresources have not only attracted organic chemists to develop strategies for total synthesis, but also attracted (chemical) biologists to investigate the mechanisms of action. The chemistry and biology of some selected compounds are also discussed in this review.

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