A one-pot three-component reaction promoted by choline chloride: zinc(II) chloride deepeutectic
solvent (ChCl-ZnCl2 DES) in an aqueous medium for the synthesis of several merocyanin
dyes based on isoxazol-5(4H)-ones is presented. This three-component approach is efficient, clean,
experimentally simple, convenient, safe, and environmentally friendly. This reaction was performed at
room temperature without using energy sources such as heat, microwave and ultrasound waves. Nonuse
of toxic solvents, available materials, one-vessel, no wasted reagents, simple preparation, and recyclability
of DES are other important points of this method that is significant from the perspective of
green chemistry.