ChemInform Abstract: A Simple Synthesis of Polysubstituted Pyrrolidines by an Organocatalytic Three-Component Approach Featuring a One-Pot Condensation and [3 + 2]-Cycloaddition Reaction in Aqueous Medium.

ChemInform ◽  
2014 ◽  
Vol 45 (8) ◽  
pp. no-no
Author(s):  
Silvia Reboredo ◽  
Jose L. Vicario ◽  
Luisa Carrillo ◽  
Efraim Reyes ◽  
Uxue Uria
Keyword(s):  
Aqueous Medium ◽  
Cycloaddition Reaction ◽  
Simple Synthesis ◽  
One Pot ◽  
One Pot Condensation ◽  
Component Approach

A new more atom-efficient multi-component approach to tetrasubstituted imidazoles: one-pot condensation of nitriles, amines and benzoin

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 67281-67289 ◽  
Author(s):  
Ali Khalafi-Nezhad ◽  
Mohsen Shekouhy ◽  
Hashem Sharghi ◽  
Jasem Aboonajmi ◽  
Abdolkarim Zare
Keyword(s):  
Primary Amines ◽  
One Pot ◽  
One Pot Condensation ◽  
Component Approach ◽  
The One ◽  
Tetrasubstituted Imidazoles

A new more atom-efficient multi-component approach for the synthesis of tetrasubstituted imidazoles via the one-pot condensation of nitriles, primary amines and benzoin has been described.

scholarly journals Synthesis of a Novel Series of Cu(I) Complexes Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane as Homogeneous and Carbon-Supported Catalysts for the Synthesis of 1- and 2-Substituted-1,2,3-triazoles

Nanomaterials ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2702
Author(s):  
Ivy L. Librando ◽  
Abdallah G. Mahmoud ◽  
Sónia A. C. Carabineiro ◽  
M. Fátima C. Guedes da Silva ◽  
Carlos F. G. C. Geraldes ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Sodium Azide ◽  
Supported Catalysts ◽  
Cycloaddition Reaction ◽  
Water Soluble ◽  
Terminal Alkynes ◽  
One Pot ◽  
Catalytic Systems ◽  
Immobilized Catalyst ◽  
High Yields

The N-alkylation of 1,3,5-triaza-7-phosphaadamantane (PTA) with ortho-, meta- and para-substituted nitrobenzyl bromide under mild conditions afforded three hydrophilic PTA ammonium salts, which were used to obtain a new set of seven water-soluble copper(I) complexes. The new compounds were fully characterized and their catalytic activity was investigated for the low power microwave assisted one-pot azide–alkyne cycloaddition reaction in homogeneous aqueous medium to obtain disubstituted 1,2,3-triazoles. The most active catalysts were immobilized on activated carbon (AC), multi-walled carbon nanotubes (CNT), as well as surface functionalized AC and CNT, with the most efficient support being the CNT treated with nitric acid and NaOH. In the presence of the immobilized catalyst, several 1,4-disubstituted-1,2,3-triazoles were obtained from the reaction of terminal alkynes, organic halides and sodium azide in moderate yields up to 80%. Furthermore, the catalyzed reaction of terminal alkynes, formaldehyde and sodium azide afforded 2-hydroxymethyl-2H-1,2,3-triazoles in high yields up to 99%. The immobilized catalyst can be recovered and recycled through simple workup steps and reused up to five consecutive cycles without a marked loss in activity. The described catalytic systems proceed with a broad substrate scope, under microwave irradiation in aqueous medium and according to “click rules”.

Green Three-component Synthesis of Merocyanin Dyes Based on 4- Arylideneisoxazol-5(4H)-ones

2020 ◽  
Vol 7 (2) ◽  
pp. 217-225
Author(s):  
Fatemeh K. Damghani ◽  
Hamzeh Kiyani ◽  
Seied A. Pourmousavi
Keyword(s):  
Green Chemistry ◽  
Aqueous Medium ◽  
Room Temperature ◽  
Choline Chloride ◽  
Energy Sources ◽  
One Pot ◽  
Ultrasound Waves ◽  
Simple Preparation ◽  
Three Component Reaction ◽  
Component Approach

A one-pot three-component reaction promoted by choline chloride: zinc(II) chloride deepeutectic solvent (ChCl-ZnCl2 DES) in an aqueous medium for the synthesis of several merocyanin dyes based on isoxazol-5(4H)-ones is presented. This three-component approach is efficient, clean, experimentally simple, convenient, safe, and environmentally friendly. This reaction was performed at room temperature without using energy sources such as heat, microwave and ultrasound waves. Nonuse of toxic solvents, available materials, one-vessel, no wasted reagents, simple preparation, and recyclability of DES are other important points of this method that is significant from the perspective of green chemistry.

Synthesis of Trans-6-(4-Chlorobenzoyl)-7-(Aryl)-1,3-Dimethyl-6,7-Dihydrofuro[3,2-d]Pyrimidine-2,4-Diones Using Choline Hydroxide as an Efficient Catalyst in an Aqueous Medium

2017 ◽  
Vol 41 (3) ◽  
pp. 139-142 ◽  
Author(s):  
Maryam Salari ◽  
Alireza Hassanabadi ◽  
Mohammad H. Mosslemin
Keyword(s):  
Aqueous Medium ◽  
Aromatic Aldehyde ◽  
Reaction Times ◽  
Efficient Synthesis ◽  
One Pot ◽  
Efficient Catalyst ◽  
Excellent Yield ◽  
One Pot Condensation

A green and efficient synthesis of the trans-6-(4-chlorobenzoyl)-7-(aryl)-1,3-dimethyl-6,7-dihydrofuro[3,2-d]pyrimidine-2,4-diones has been achieved via a three-component, one-pot condensation of 2-[2-(4-chlorophenyl)-2-oxoethyl)]isoquinolinium bromide with 1,3-dimethylbarbituric acid and an aromatic aldehyde in the presence of catalytic amounts of choline hydroxide in water under reflux conditions. This gives trans-6-(4-chlorobenzoyl)-7-(aryl)-1,3-dimethyl-6,7-dihydrofuro[3,2-d]pyrimidine-2,4-diones in excellent yield and in short reaction times.

ChemInform Abstract: A New More Atom-Efficient Multi-Component Approach to Tetrasubstituted Imidazoles: One-Pot Condensation of Nitriles, Amines and Benzoin.

ChemInform ◽  
2016 ◽  
Vol 47 (48) ◽  
Author(s):  
Ali Khalafi-Nezhad ◽  
Mohsen Shekouhy ◽  
Hashem Sharghi ◽  
Jasem Aboonajmi ◽  
Abdolkarim Zare
Keyword(s):  
One Pot ◽  
One Pot Condensation ◽  
Component Approach ◽  
Tetrasubstituted Imidazoles

scholarly journals Ecofriendly and simple synthesis of pyrano[3,2-c]quinolone in water via an efficient one-pot three-component reaction

2018 ◽  
Vol 9 (1) ◽  
pp. 44-48
Author(s):  
Ibrahim Ali Radini ◽  
Sameh Ramadan El-Gogary ◽  
Mohamed Sabri Mostafa ◽  
Bander Alnagei ◽  
Mohammed Mudarbish ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Biological Activities ◽  
Catalytic Amount ◽  
Simple Synthesis ◽  
One Pot ◽  
Three Component Reaction ◽  
Active Methylene

Pyrano[3,2-c]quinolones are commonly found in alkaloids, manifesting diverse biological activities. In this work, 2-amino-6-methyl-5-oxo-4-substituted-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carbonitriles and ethyl 2-amino-4-(substituted)-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates have been synthesized efficiently from reaction of 4-hydroxy-1-methylquinolin-2(1H)-one, aldehydes and active methylene nitriles in one-pot three component reaction in aqueous medium, containing catalytic amount of ethanolamine resulting in 70-95% yields.

Green synthesis of trans-(4-chlorophenyl)-7-aryl-6,7-dihydro[1,3]dioxolo[4,5-f][1]benzofuran-6-yl)methanones in an aqueous medium

2019 ◽  
Vol 43 (3-4) ◽  
pp. 86-89
Author(s):  
Mohammad Reza Salari ◽  
Mohammad H Mosslemin ◽  
Alireza Hassanabadi
Keyword(s):  
Green Synthesis ◽  
Aqueous Medium ◽  
One Pot ◽  
Excellent Yield ◽  
One Pot Condensation ◽  
Short Time

A three-component one-pot condensation of 2-[2-(4-chlorophenyl)-2-oxoethyl)]isoquinolinium bromide with benzo[1,3]dioxol-5-ol and an arylglyoxal in the presence of catalytic amounts of 1,4-diaza-bicyclo[2.2.2]octane in refluxing water gave a series of seven trans-(4-chlorophenyl)-7-aryl-6,7-dihydro[1,3]dioxolo[4,5- f][1]benzofuran-6-yl)methanones in excellent yield and in a short time.

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