ChemInform Abstract: New Derivatives of 2-(3,5-Dioxo-4-azatricyclo [5.2.1.02,6-endo]dec-8-en-4-yl)acetic Acid. Synthesis and Reactivity.

ChemInform ◽  
2008 ◽  
Vol 39 (10) ◽  
Author(s):  
I. N. Tarabara ◽  
Ya. S. Bondarenko ◽  
A. A. Zhurakovskii ◽  
L. I. Kas'yan
Keyword(s):  
Acetic Acid ◽  
Acid Synthesis ◽  
Derivatives Of

New derivatives of xanthenone-4-acetic acid: Synthesis, pharmacological profile and effect on TNF-α and NO production by human immune cells

2006 ◽  
Vol 14 (12) ◽  
pp. 4101-4109 ◽  
Author(s):  
Silvia Gobbi ◽  
Federica Belluti ◽  
Alessandra Bisi ◽  
Lorna Piazzi ◽  
Angela Rampa ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Immune Cells ◽  
Acid Synthesis ◽  
No Production ◽  
Pharmacological Profile ◽  
Tnf Α ◽  
Human Immune ◽  
Derivatives Of

New derivatives of 2-(3,5-Dioxo-4-azatricyclo[5.2.1.02,6-endo ]dec-8-en-4-yl)acetic acid. Synthesis and reactivity

2007 ◽  
Vol 43 (9) ◽  
pp. 1297-1304 ◽  
Author(s):  
I. N. Tarabara ◽  
Ya. S. Bondarenko ◽  
A. A. Zhurakovskii ◽  
L. I. Kas’yan
Keyword(s):  
Acetic Acid ◽  
Acid Synthesis ◽  
Derivatives Of

Synthesis of 1,2,4-triazine-3,5(2H,4H)-diones containing electronegative substituents in position 6

1983 ◽  
Vol 48 (9) ◽  
pp. 2676-2681 ◽  
Author(s):  
Jiří Farkaš
Keyword(s):  
Hydrogen Peroxide ◽  
Acetic Acid ◽  
Nitro Compound ◽  
Trifluoroacetic Acid ◽  
Acid Synthesis ◽  
Amino Derivative ◽  
Effect Of Substituents ◽  
Fluoro Derivative ◽  
Cuprous Cyanide ◽  
Derivatives Of

Reaction of fluorine with 1,2,4-triazine-3,5(2H,4H)-dione (I) in acetic acid afforded the 6-fluoro derivative II in low yield. The 6-nitro compound III was prepared by oxidation of the 6-amino derivative of compound I with hydrogen peroxide in trifluoroacetic acid. Synthesis of the 6-cyano compound IV was accomplished by treatment of the 6-bromo derivative with cuprous cyanide in N,N,N',N'-tetramethylurea. The effect of substituents on the carbonyl frequencies for 6-substituted derivatives of I was studied.

Fluorinated tricyclic neuroleptics with prolonged action: 8-Methoxy, 8-ethoxy, 8-ethylthio and 8-hydroxy derivatives of 3-fluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin

1982 ◽  
Vol 47 (5) ◽  
pp. 1382-1391 ◽  
Author(s):  
Jiří Jílek ◽  
Josef Pomykáček ◽  
Jiřina Metyšová ◽  
Miroslav Protiva
Keyword(s):  
Acetic Acid ◽  
Polyphosphoric Acid ◽  
Prolonged Action ◽  
Substitution Reactions ◽  
Methoxy Derivative ◽  
Chloro Derivatives ◽  
Boron Tribromide ◽  
Derivatives Of ◽  
Central Depressant ◽  
Boiling Toluene

Acids IIa-c were prepared by reactions of (4-fluoro-2-iodophenyl)acetic acid with 4-methoxythiophenol, 4-ethoxythiophenol and 4-(ethylthio)thiophenol and cyclized with polyphosphoric acid in boiling toluene to dibenzo[b,f]thiepin-10(11H)-ones IIIa-c. Reduction with sodium borohydride afforded the alcohols IVa-c which were treated with hydrogen chloride and gave the chloro derivatives Va-c. Substitution reactions with 1-methylpiperazine resulted in the title compounds Ia-c out of which the methoxy derivative Ia was transformed by demethylation with boron tribromide to the phenol Id. Compounds Ia-d are very potent neuroleptics exhibiting a clear prolongation of the central depressant and some prolongation of the cataleptic activity.

ChemInform Abstract: DIHALO DERIVATIVES OF NAPHTHOSTYRIL-N-ACETIC ACID

1978 ◽  
Vol 9 (34) ◽  
Author(s):  
A. P. KARISHIN ◽  
A. A. PECHKA ◽  
N. F. GRINEVA
Keyword(s):  
Acetic Acid ◽  
Derivatives Of
Sign in / Sign up

Export Citation Format

Share Document