Development of a redox/pH dual stimuli-responsive MSP@P(MAA-Cy) drug delivery system for programmed release of anticancer drugs in tumour cells

2014 ◽  
Vol 2 (32) ◽  
pp. 5187-5194 ◽  
Author(s):  
Dian Li ◽  
Yuting Zhang ◽  
Sha Jin ◽  
Jia Guo ◽  
Haifeng Gao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Therapeutic Effect ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Tumour Cells ◽  
Stimuli Responsive ◽  
Programmed Release

A redox/pH dual-stimuli-responsive drug delivery system for programmed release of anticancer drugs has been developed for enhancing the therapeutic effect.

Schiff base-containing dextran nanogel as pH-sensitive drug delivery system of doxorubicin: Synthesis and characterization

2018 ◽  
Vol 33 (2) ◽  
pp. 170-181 ◽  
Author(s):  
Hongying Su ◽  
Wen Zhang ◽  
Yayun Wu ◽  
Xiaodong Han ◽  
Gang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Cell Uptake ◽  
Stimuli Responsive ◽  
Drug Release Profile

Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2.0, 5.0) than that at pH 7.4. Approximately 66, 28, and 9% of drug was released in 72 h at pH 2.0, 5.0, and 7.4, respectively. Cell uptake by the human breast cancer cell (MCF-7) demonstrated that the DOX-loaded dextran nanogel could be internalized through endocytosis and distributed in endocytic compartments inside tumor cells. These results indicated that the Schiff base-containing nanogel can serve as a pH-sensitive drug delivery system. And the presence of multiple aldehyde groups on the nanogel are available for further conjugations of targeting ligands or imaging probes.

A novel progress of drug delivery system for organelle targeting in tumour cells

2020 ◽  
Vol 29 (1) ◽  
pp. 12-28
Author(s):  
Zhijing He ◽  
Yanan Zhang ◽  
Abdur Rauf Khan ◽  
Jianbo Ji ◽  
Aihua Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumour Cells ◽  
Organelle Targeting

Preparation of keratin/chlorhexidine complex nanoparticles for long-term and dual stimuli-responsive release

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 82334-82341 ◽  
Author(s):  
Xuelian Zhi ◽  
Yanfang Wang ◽  
Pengfei Li ◽  
Jiang Yuan ◽  
Jian Shen
Keyword(s):  
Drug Delivery ◽  
Complex Formation ◽  
Drug Delivery System ◽  
Delivery System ◽  
Convenient Method ◽  
Stimuli Responsive ◽  
Polyion Complex

Nanoscale polyion complex formation via the electrostatic complexation of a polyelectrolyte and a charged drug is the most convenient method for building a drug delivery system that simultaneously realizes the carrier preparation and drug embedding.

Evaluation of superabsorbent linseed-polysaccharides as a novel stimuli-responsive oral sustained release drug delivery system

2016 ◽  
Vol 43 (3) ◽  
pp. 409-420 ◽  
Author(s):  
Muhammad Tahir Haseeb ◽  
Muhammad Ajaz Hussain ◽  
Sajid Bashir ◽  
Muhammad Umer Ashraf ◽  
Naveed Ahmad
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stimuli Responsive ◽  
Release Drug
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