The First Biosynthetic Studies of the Azinomycins: Acetate Incorporation into Azinomycin B.

ChemInform ◽  
2004 ◽  
Vol 35 (35) ◽  
Author(s):  
Christophe Corre ◽  
Philip A. S. Lowden
Keyword(s):  
Acetate Incorporation ◽  
Azinomycin B ◽  
Biosynthetic Studies

Biosynthetic Studies of the Male Marking Pheromone in Bumblebees by Using Labelled Fatty Acids and Two-Dimensional Gas Chromatography with Mass Detection

ChemPlusChem ◽  
2015 ◽  
Vol 80 (5) ◽  
pp. 839-850 ◽  
Author(s):  
Petr Žáček ◽  
Jiří Kindl ◽  
Kateřina Frišonsová ◽  
Markéta Průchová ◽  
Alena Votavová ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gas Chromatography ◽  
Two Dimensional ◽  
Mass Detection ◽  
Marking Pheromone ◽  
Biosynthetic Studies

scholarly journals Structural and biosynthetic studies of a principal bile alcohol, 27-nor-5β-cholestane-3α,7α,12α,24,25-pentol, in human urine

2000 ◽  
Vol 41 (10) ◽  
pp. 1562-1567
Author(s):  
Mizuho Une ◽  
Shinji Takenaka ◽  
Taiju Kuramoto ◽  
Kingo Fujimura ◽  
Takahiko Hoshita ◽  
...  
Keyword(s):  
Human Urine ◽  
Bile Alcohol ◽  
Biosynthetic Studies

METABOLISM IN ADIPOSE TISSUE AND MUSCLE OF THE YOUNG PIG

1990 ◽  
Vol 70 (1) ◽  
pp. 199-206 ◽  
Author(s):  
O. ADEOLA ◽  
B. W. McBRIDE ◽  
R. O. BALL ◽  
L. G. YOUNG
Keyword(s):  
Skeletal Muscle ◽  
Protein Synthesis ◽  
Adipose Tissue ◽  
Key Words ◽  
Adenosine Deaminase ◽  
Subcutaneous Adipose Tissue ◽  
Muscle Metabolism ◽  
Acetate Incorporation ◽  
Glycerol Release ◽  
Subcutaneous Adipose

Subcutaneous adipose tissue and intercostal and sartorius muscles from five barrows and five gilts at 20 kg liveweight were used to study lipogenesis, lipolysis, Na+, K+-ATPase-dependent respiration and protein synthesis. Lipogenesis rate measured by 14C-acetate incorporation into lipid was similar between barrows and gilts; and 100 μg insulin per mL enhanced (P < 0.1) subcutaneous adipose tissue lipogenesis by 74%. Lipolysis rate quantitated by glycerol release was similar between barrows and gilts (3546 and 4160 nmol g−1 2 h−1). Adenosine deaminase and norepinephrine together enhanced adipose tissue lipolytic response by 102%. Fractional and absolute rates of protein synthesis were similar between barrows and gilts (3.24 and 3.69% d−1; 6.01 and 6.06 mg g−1 d−1); and between intercostal and sartorius muscles. Barrows had lower Na+, K+-ATPase-dependent respiration than gilts and the maintenance of Na+ and K+ transmembrane ionic gradient in the muscle preparations accounted for 23–26% of total respiration. Key words: Pigs, adipose tissue, skeletal muscle, metabolism

scholarly journals Modulation of lipid-synthesizing enzymes by insulin in differentiated ob17 adipose-like cells

1983 ◽  
Vol 214 (2) ◽  
pp. 443-449 ◽  
Author(s):  
P Grimaldi ◽  
C Forest ◽  
P Poli ◽  
R Negrel ◽  
G Ailhaud
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Specific Activity ◽  
Fatty Acid Synthetase ◽  
Lipid Synthesis ◽  
Acid Synthesis ◽  
Acetate Incorporation ◽  
Long Term Effects ◽  
Response Curves ◽  
Glycerol 3 Phosphate Dehydrogenase

ob17 cells convert into adipose-like cells when maintained in the presence of physiological concentrations of insulin and tri-iodothyronine. After this conversion, insulin removal from differentiated ob17 cells gives within 24-48 h a large decrease in fatty acid synthetase, glycerol 3-phosphate dehydrogenase and acid:CoA ligase activities, as well as in the rate of fatty acid synthesis determined by [14C]acetate incorporation into lipids. All parameters are restored by insulin addition to initial values within 24-48 h. Dose-response curves of insulin on the restoration of glycerol 3-phosphate dehydrogenase activity and of fatty acid synthesis give half-maximally effective concentrations close to 1 nM, in agreement with the affinity for insulin of the insulin receptors previously characterized in these cells. Immunotitration experiments indicate that the changes in the specific activity of fatty acid synthetase are due to parallel changes in the cellular enzyme content. Therefore the ob17 cell line should be a useful model to study the long-term effects of insulin on the modulation of lipid synthesis in adipose cells.

scholarly journals Nef Induces Multiple Genes Involved in Cholesterol Synthesis and Uptake in Human Immunodeficiency Virus Type 1-Infected T Cells

2005 ◽  
Vol 79 (15) ◽  
pp. 10053-10058 ◽  
Author(s):  
Angélique B. van ′t Wout ◽  
J. Victor Swain ◽  
Michael Schindler ◽  
Ushnal Rao ◽  
Melissa S. Pathmajeyan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cholesterol Synthesis ◽  
Cholesterol Biosynthesis ◽  
Acetate Incorporation ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Several recent reports indicate that cholesterol might play an important role in human immunodeficiency virus type 1 (HIV-1) replication. We investigated the effects of HIV-1 infection on cholesterol biosynthesis and uptake using microarrays. HIV-1 increased gene expression of cholesterol genes in both transformed T-cell lines and primary CD4+ T cells. Consistent with our microarray data, 14C-labeled mevalonate and acetate incorporation was increased in HIV-1-infected cells. Our data also demonstrate that changes in cholesterol biosynthesis and uptake are only observed in the presence of functional Nef, suggesting that increased cholesterol synthesis may contribute to Nef-mediated enhancement of virion infectivity and viral replication.

scholarly journals alpha-Thalassaemia in Apulia: biosynthetic studies.

1983 ◽  
Vol 20 (3) ◽  
pp. 206-209
Author(s):  
G Guanti ◽  
A Lonoce ◽  
A Pietrapertosa ◽  
G Polimeno ◽  
N Tannoia
Keyword(s):  
Alpha Thalassaemia ◽  
Biosynthetic Studies

Biosynthetic Studies on the α-Glucosidase Inhibitor Acarbose inActinoplanessp.:  2-epi-5-epi-Valiolone Is the Direct Precursor of the Valienamine Moiety

1999 ◽  
Vol 121 (30) ◽  
pp. 6973-6983 ◽  
Author(s):  
Taifo Mahmud ◽  
Ingo Tornus ◽  
Erin Egelkrout ◽  
Eckardt Wolf ◽  
Charmaine Uy ◽  
...  
Keyword(s):  
Glucosidase Inhibitor ◽  
Biosynthetic Studies
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