Synthesis, Topoisomerase I Inhibition and Structure—Activity Relationship Study of 2,4,6-Trisubstituted Pyridine Derivatives.

ChemInform ◽  
2004 ◽  
Vol 35 (26) ◽  
Author(s):  
Yurngdong Jahng ◽  
Eung-Seok Lee ◽  
et al. et al.
Keyword(s):  
Topoisomerase I ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Pyridine Derivatives ◽  
Structure Activity ◽  
Relationship Study

A facile one-pot multi-component synthesis of novel adamantine substituted imidazo[1,2-a]pyridine derivatives: identification and structure–activity relationship study of their anti-HIV-1 activity

RSC Advances ◽  
2016 ◽  
Vol 6 (97) ◽  
pp. 95177-95188 ◽  
Author(s):  
Tazeem Tazeem ◽  
Xin Han ◽  
Qingjun Zhou ◽  
Jingchen Wei ◽  
Po Tien ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Pyridine Derivatives ◽  
One Pot ◽  
Structure Activity ◽  
Relationship Study ◽  
Anti Hiv ◽  
Hiv 1

A series of adamantine substituted imidazo[1,2-a]pyridine derivatives were developed through a one-pot multi-component Groebke–Blackburn–Bienaymé reaction, among them several compounds were identified to be the potent inhibitors against HIV-1 cells.

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