A facile one-pot multi-component synthesis of novel adamantine substituted imidazo[1,2-a]pyridine derivatives: identification and structure–activity relationship study of their anti-HIV-1 activity

RSC Advances ◽  
2016 ◽  
Vol 6 (97) ◽  
pp. 95177-95188 ◽  
Author(s):  
Tazeem Tazeem ◽  
Xin Han ◽  
Qingjun Zhou ◽  
Jingchen Wei ◽  
Po Tien ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Pyridine Derivatives ◽  
One Pot ◽  
Structure Activity ◽  
Relationship Study ◽  
Anti Hiv ◽  
Hiv 1

A series of adamantine substituted imidazo[1,2-a]pyridine derivatives were developed through a one-pot multi-component Groebke–Blackburn–Bienaymé reaction, among them several compounds were identified to be the potent inhibitors against HIV-1 cells.

Anti-HIV-1 activity of thiadiazole derivatives: structure-activity relationship, reverse transcriptase inhibition, and lipophilicity

1996 ◽  
Vol 31 (1-2) ◽  
pp. 87-94 ◽  
Author(s):  
Katsushi Ijichi ◽  
Masatoshi Fujiwara ◽  
Hideki Nagano ◽  
Yukiharu Matsumoto ◽  
Yasuaki Hanasaki ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Thiadiazole Derivatives ◽  
Anti Hiv ◽  
Hiv 1
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