Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure–activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor

Pervez Ahmad; Hyunjung Woo; Kyu-Yeon Jun; Adnan A. Kadi; Hatem A. Abdel-Aziz; Youngjoo Kwon; A.F.M. Motiur Rahman

doi:10.1016/j.bmc.2016.03.017

Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure–activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2016.03.017 ◽

2016 ◽

Vol 24 (8) ◽

pp. 1898-1908 ◽

Cited By ~ 14

Author(s):

Pervez Ahmad ◽

Hyunjung Woo ◽

Kyu-Yeon Jun ◽

Adnan A. Kadi ◽

Hatem A. Abdel-Aziz ◽

...

Keyword(s):

Antiproliferative Activity ◽

Inhibitory Activity ◽

Topoisomerase I ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Topoisomerase Iiα ◽

Design Synthesis ◽

Structure Activity ◽

Catalytic Inhibitor ◽

Relationship Study

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Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.03.051 ◽

2010 ◽

Vol 18 (9) ◽

pp. 3066-3077 ◽

Cited By ~ 68

Author(s):

Radha Karki ◽

Pritam Thapa ◽

Mi Jeong Kang ◽

Tae Cheon Jeong ◽

Jung Min Nam ◽

...

Keyword(s):

Inhibitory Activity ◽

Topoisomerase I ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study

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Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2012.01.015 ◽

2012 ◽

Vol 49 ◽

pp. 219-228 ◽

Cited By ~ 49

Author(s):

Radha Karki ◽

Pritam Thapa ◽

Han Young Yoo ◽

Tara Man Kadayat ◽

Pil-Hoon Park ◽

...

Keyword(s):

Inhibitory Activity ◽

Topoisomerase I ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study

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ChemInform Abstract: Dihydroxylated 2,4,6-Triphenyl Pyridines: Synthesis, Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure-Activity Relationship Study.

ChemInform ◽

10.1002/chin.201231150 ◽

2012 ◽

Vol 43 (31) ◽

pp. no-no

Author(s):

Eung-Seok Lee ◽

et al. et al.

Keyword(s):

Inhibitory Activity ◽

Topoisomerase I ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study

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Synthesis, Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure-activity Relationship Study of Rigid Analogues of 2,4,6-Trisubstituted Pyridine Containing 5,6-Dihydrobenzo[h]quinoline Moiety

Bulletin of the Korean Chemical Society ◽

10.5012/bkcs.2011.32.1.303 ◽

2011 ◽

Vol 32 (1) ◽

pp. 303-306 ◽

Cited By ~ 18

Author(s):

Byeong-Seon Jeong ◽

Ho-Young Choi ◽

Pritam Thapa ◽

Radha Karki ◽

Eun-Young Lee ◽

...

Keyword(s):

Inhibitory Activity ◽

Topoisomerase I ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study ◽

Quinoline Moiety

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ChemInform Abstract: Synthesis, Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure-Activity Relationship Study of Rigid Analogues of 2,4,6-Trisubstituted Pyridine Containing 5,6-Dihydrobenzo[h]quinoline Moiety.

ChemInform ◽

10.1002/chin.201124151 ◽

2011 ◽

Vol 42 (24) ◽

pp. no-no

Author(s):

Eung-Seok Lee ◽

et al. et al.

Keyword(s):

Inhibitory Activity ◽

Topoisomerase I ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study ◽

Quinoline Moiety

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Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.04.031 ◽

2015 ◽

Vol 23 (13) ◽

pp. 3499-3512 ◽

Cited By ~ 18

Author(s):

Tara Man Kadayat ◽

Chanju Song ◽

Somin Shin ◽

Til Bahadur Thapa Magar ◽

Ganesh Bist ◽

...

Keyword(s):

Inhibitory Activity ◽

Topoisomerase I ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study

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2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study

Bioorganic Chemistry ◽

10.1016/j.bioorg.2011.09.001 ◽

2012 ◽

Vol 40 ◽

pp. 67-78 ◽

Cited By ~ 18

Author(s):

Pritam Thapa ◽

Radha Karki ◽

Han Young Yoo ◽

Pil-Hoon Park ◽

Eunyoung Lee ◽

...

Keyword(s):

Inhibitory Activity ◽

Topoisomerase I ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quinoline Derivatives ◽

Structure Activity ◽

Relationship Study

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2-Thienyl-4-furyl-6-aryl pyridine derivatives: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.10.049 ◽

2010 ◽

Vol 18 (1) ◽

pp. 377-386 ◽

Cited By ~ 51

Author(s):

Pritam Thapa ◽

Radha Karki ◽

Uttam Thapa ◽

Yurngdong Jahng ◽

Mi-Ja Jung ◽

...

Keyword(s):

Inhibitory Activity ◽

Topoisomerase I ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Pyridine Derivatives ◽

Structure Activity ◽

Relationship Study

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Topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.04.002 ◽

2015 ◽

Vol 23 (13) ◽

pp. 3638-3654 ◽

Cited By ~ 17

Author(s):

Radha Karki ◽

Chanju Song ◽

Tara Man Kadayat ◽

Til Bahadur Thapa Magar ◽

Ganesh Bist ◽

...

Keyword(s):

Inhibitory Activity ◽

Topoisomerase I ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study

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Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113291 ◽

2021 ◽

pp. 113291

Author(s):

Peng Li ◽

Ying Liu ◽

Hua Yang ◽

Hong-Min Liu

Keyword(s):

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study

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