cycloSaligenyl Pronucleotides of 5-Iodo and 5-Trifluoromethyl-1- (2-deoxy-β-D-ribofuranosyl)-2,4-difluorobenzene Mimics of Thymidine: Synthesis and Evaluation of This Pronucleotide Monophosphate Delivery System for Compounds with Potential Anticancer Activity.

ChemInform ◽  
2004 ◽  
Vol 35 (16) ◽  
Author(s):  
Wei Yan Sun ◽  
Aihua Zhou ◽  
Leonard I. Wiebe ◽  
Edward E. Knaus
Keyword(s):  
Anticancer Activity ◽  
Delivery System ◽  
Thymidine Synthesis

scholarly journals Multi-Walled Carbon Nanotubes Decorated with Guanidinylated Dendritic Molecular Transporters: An Efficient Platform for the Selective Anticancer Activity of Doxorubicin

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 858
Author(s):  
Kyriaki-Marina Lyra ◽  
Archontia Kaminari ◽  
Katerina N. Panagiotaki ◽  
Konstantinos Spyrou ◽  
Sergios Papageorgiou ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Delivery System ◽  
Colloidal Stability ◽  
Triggered Release ◽  
Selective Toxicity ◽  
Molecular Transporters ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

An efficient doxorubicin (DOX) drug delivery system with specificity against tumor cells was developed, based on multi-walled carbon nanotubes (MWCNTs) functionalized with guanidinylated dendritic molecular transporters. Acid-treated MWCNTs (oxCNTs) interacted both electrostatically and through hydrogen bonding and van der Waals attraction forces with guanidinylated derivatives of 5000 and 25,000 Da molecular weight hyperbranched polyethyleneimine (GPEI5K and GPEI25K). Chemical characterization of these GPEI-functionalized oxCNTs revealed successful decoration with GPEIs all over the oxCNTs sidewalls, which, due to the presence of guanidinium groups, gave them aqueous compatibility and, thus, exceptional colloidal stability. These GPEI-functionalized CNTs were subsequently loaded with DOX for selective anticancer activity, yielding systems of high DOX loading, up to 99.5% encapsulation efficiency, while the DOX-loaded systems exhibited pH-triggered release and higher therapeutic efficacy compared to that of free DOX. Most importantly, the oxCNTs@GPEI5K-DOX system caused high and selective toxicity against cancer cells in a non-apoptotic, fast and catastrophic manner that cancer cells cannot recover from. Therefore, the oxCNTs@GPEI5K nanocarrier was found to be a potent and efficient nanoscale DOX delivery system, exhibiting high selectivity against cancerous cells, thus constituting a promising candidate for cancer therapy.

scholarly journals Anticancer activity of stoppin based on a novel peptide delivery system

2015 ◽  
Vol 12 (4) ◽  
pp. 5437-5442 ◽  
Author(s):  
YAN-FANG GAO ◽  
XUE-NI WEI ◽  
XIAO-LEI YE ◽  
GUO-BIN WENG ◽  
YI-CHEN CHEN ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Delivery System ◽  
Peptide Delivery

scholarly journals Biocompatibility and anticancer activity of L-phenyl alanine-coated iron oxide magnetic nanoparticles as potential chrysin delivery system—CORRIGENDUM

2019 ◽  
Vol 34 (23) ◽  
pp. 3976-3976
Author(s):  
Hamed Nosrati ◽  
Elham Javani ◽  
Marziyeh Salehiabar ◽  
Hamidreza Kheiri Manjili ◽  
Soodabeh Davaran ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Anticancer Activity ◽  
Delivery System ◽  
Iron Oxide Magnetic Nanoparticles ◽  
Phenyl Alanine

scholarly journals Nitrogen-doped carbon nanodots for bioimaging and delivery of paclitaxel

2018 ◽  
Vol 6 (35) ◽  
pp. 5540-5548 ◽  
Author(s):  
I. Jennifer Gomez ◽  
Blanca Arnaiz ◽  
Michele Cacioppo ◽  
Francesca Arcudi ◽  
Maurizio Prato
Keyword(s):  
Drug Delivery ◽  
Anticancer Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Free Drug ◽  
Carbon Nanodots ◽  
Nitrogen Doped ◽  
Nitrogen Doped Carbon

A carbon nanodot–paclitaxel drug delivery system with enhanced anticancer activity as compared to the free drug is reported.

Liposome as drug delivery system enhance anticancer activity of iridium (III) complex

2020 ◽  
pp. 1-14
Author(s):  
Yiying Gu ◽  
Lan Bai ◽  
Yuanyuan Zhang ◽  
Huiwen Zhang ◽  
Degang Xing ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Activity ◽  
Drug Delivery System ◽  
Delivery System

Design of Curcumin Loaded Carbon Nanodots Delivery System: Enhanced Bioavailability, Release Kinetics, and Anticancer Activity

2020 ◽  
Vol 3 (12) ◽  
pp. 8776-8785
Author(s):  
Durga M. Arvapalli ◽  
Alex T. Sheardy ◽  
Kokougan Allado ◽  
Harish Chevva ◽  
Ziyu Yin ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Delivery System ◽  
Release Kinetics ◽  
Carbon Nanodots
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