Design of Curcumin Loaded Carbon Nanodots Delivery System: Enhanced Bioavailability, Release Kinetics, and Anticancer Activity

2020 ◽  
Vol 3 (12) ◽  
pp. 8776-8785
Author(s):  
Durga M. Arvapalli ◽  
Alex T. Sheardy ◽  
Kokougan Allado ◽  
Harish Chevva ◽  
Ziyu Yin ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Delivery System ◽  
Release Kinetics ◽  
Carbon Nanodots

scholarly journals Nitrogen-doped carbon nanodots for bioimaging and delivery of paclitaxel

2018 ◽  
Vol 6 (35) ◽  
pp. 5540-5548 ◽  
Author(s):  
I. Jennifer Gomez ◽  
Blanca Arnaiz ◽  
Michele Cacioppo ◽  
Francesca Arcudi ◽  
Maurizio Prato
Keyword(s):  
Drug Delivery ◽  
Anticancer Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Free Drug ◽  
Carbon Nanodots ◽  
Nitrogen Doped ◽  
Nitrogen Doped Carbon

A carbon nanodot–paclitaxel drug delivery system with enhanced anticancer activity as compared to the free drug is reported.

scholarly journals Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

2016 ◽  
Vol 7 ◽  
pp. 1861-1870 ◽  
Author(s):  
Huijuan Zhang ◽  
Fuqiang Wu ◽  
Yazhen Li ◽  
Xiping Yang ◽  
Jiamei Huang ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Delivery System ◽  
Water Solubility ◽  
Release Kinetics ◽  
Drug Loading ◽  
Chitosan Nanoparticles ◽  
In Vitro Release ◽  
Male Rats ◽  
Spherical Particles ◽  
Pharmacokinetic Studies

In addition to its well-known abortifacient effect, mifepristone (MIF) has been used as an anticancer drug for various cancers in many studies with an in-depth understanding of the mechanism of action. However, application of MIF is limited by its poor water solubility and low oral bioavailability. In this work, we developed a drug delivery system based on chitosan nanoparticles (CNs) to improve its bioavailability and anticancer activity. The MIF-loaded chitosan nanoparticles (MCNs) were prepared by convenient ionic gelation techniques between chitosan (Cs) and tripolyphosphate (TPP). The preparation conditions, including Cs concentration, TPP concentration, Cs/MIF mass ratio, and pH value of the TPP solution, were optimized to gain better encapsulation efficiency (EE) and drug loading capacity (DL). MCNs prepared with the optimum conditions resulted in spherical particles with an average size of 200 nm. FTIR and XRD spectra verified that MIF was successfully encapsulated in CNs. The EE and DL of MCNs determined by HPLC were 86.6% and 43.3%, respectively. The in vitro release kinetics demonstrated that MIF was released from CNs in a sustained-release manner. Compared with free MIF, MCNs demonstrated increased anticancer activity in several cancer cell lines. Pharmacokinetic studies in male rats that were orally administered MCNs showed a 3.2-fold increase in the area under the curve from 0 to 24 h compared with free MIF. These results demonstrated that MCNs could be developed as a potential delivery system for MIF to improve its anticancer activity and bioavailability.

Design of Lamivudine Loaded Nanoparticles for Oral Application by Nano Spray Drying Method: A New Approach to use an Antiretroviral Drug for Lung Cancer Treatment

2020 ◽  
Vol 23 (10) ◽  
pp. 1064-1079
Author(s):  
Ahmet Alper Öztürk ◽  
İrem Namlı ◽  
Kadri Güleç ◽  
Şennur Görgülü
Keyword(s):  
Lung Cancer ◽  
Cancer Treatment ◽  
Anticancer Activity ◽  
Cell Line ◽  
Anticancer Drugs ◽  
Release Kinetics ◽  
Prolonged Release ◽  
Lung Cancer Treatment ◽  
Anticancer Properties ◽  
Ft Ir

Aims: To prepare lamivudine (LAM)-loaded-nanoparticles (NPs) that can be used in lung cancer treatment. To change the antiviral indication of LAM to anticancer. Background: The development of anticancer drugs is a difficult process. One approach to accelerate the availability of drugs is to reclassify drugs approved for other conditions as anticancer. The most common route of administration of anticancer drugs is intravenous injection. Oral administration of anticancer drugs may considerably change current treatment modalities of chemotherapy and improve the life quality of cancer patients. There is also a potentially significant economic advantage. Objective: To characterize the LAM-loaded-NPs and examine the anticancer activity. Methods: LAM-loaded-NPs were prepared using Nano Spray-Dryer. Properties of NPs were elucidated by particle size (PS), polydispersity index (PDI), zeta potential (ZP), SEM, encapsulation efficiency (EE%), dissolution, release kinetics, DSC and FT-IR. Then, the anticancer activity of all NPs was examined. Results: The PS values of the LAM-loaded-NPs were between 373 and 486 nm. All NPs prepared have spherical structure and positive ZP. EE% was in a range of 61-79%. NPs showed prolonged release and the release kinetics fitted to the Weibull model. NPs structures were clarified by DSC and FT-IR analysis. The results showed that the properties of NPs were directly related to the drug:polymer ratio of feed solution. NPs have potential anticancer properties against A549 cell line at low concentrations and non-toxic to CCD 19-Lu cell line. Conclusion: NPs have potential anticancer properties against human lung adenocarcinoma cells and may induce cell death effectively and be a potent modality to treat this type of cancer. These experiments also indicate that our formulations are non-toxic to normal cells. It is clear that this study would bring a new perspective to cancer therapy.

scholarly journals Multi-Walled Carbon Nanotubes Decorated with Guanidinylated Dendritic Molecular Transporters: An Efficient Platform for the Selective Anticancer Activity of Doxorubicin

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 858
Author(s):  
Kyriaki-Marina Lyra ◽  
Archontia Kaminari ◽  
Katerina N. Panagiotaki ◽  
Konstantinos Spyrou ◽  
Sergios Papageorgiou ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Delivery System ◽  
Colloidal Stability ◽  
Triggered Release ◽  
Selective Toxicity ◽  
Molecular Transporters ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

An efficient doxorubicin (DOX) drug delivery system with specificity against tumor cells was developed, based on multi-walled carbon nanotubes (MWCNTs) functionalized with guanidinylated dendritic molecular transporters. Acid-treated MWCNTs (oxCNTs) interacted both electrostatically and through hydrogen bonding and van der Waals attraction forces with guanidinylated derivatives of 5000 and 25,000 Da molecular weight hyperbranched polyethyleneimine (GPEI5K and GPEI25K). Chemical characterization of these GPEI-functionalized oxCNTs revealed successful decoration with GPEIs all over the oxCNTs sidewalls, which, due to the presence of guanidinium groups, gave them aqueous compatibility and, thus, exceptional colloidal stability. These GPEI-functionalized CNTs were subsequently loaded with DOX for selective anticancer activity, yielding systems of high DOX loading, up to 99.5% encapsulation efficiency, while the DOX-loaded systems exhibited pH-triggered release and higher therapeutic efficacy compared to that of free DOX. Most importantly, the oxCNTs@GPEI5K-DOX system caused high and selective toxicity against cancer cells in a non-apoptotic, fast and catastrophic manner that cancer cells cannot recover from. Therefore, the oxCNTs@GPEI5K nanocarrier was found to be a potent and efficient nanoscale DOX delivery system, exhibiting high selectivity against cancerous cells, thus constituting a promising candidate for cancer therapy.

Release Kinetics of Acyclovir from a Suspension of Acyclovir Incorporated in a Cubic Phase Delivery System

2001 ◽  
Vol 27 (10) ◽  
pp. 1073-1081 ◽  
Author(s):  
Lise Sylvest Nielsen ◽  
Lise Sylvest Helledi ◽  
Lene Schubert
Keyword(s):  
Delivery System ◽  
Release Kinetics ◽  
Cubic Phase ◽  
Kinetics Of

Denatured collagen as support for a FGF-2 delivery system: physicochemical characterizations and in vitro release kinetics and bioactivity

Biomaterials ◽  
2004 ◽  
Vol 25 (17) ◽  
pp. 3761-3772 ◽  
Author(s):  
Marie-France Côté ◽  
Gaetan Laroche ◽  
Edith Gagnon ◽  
Pascale Chevallier ◽  
Charles J Doillon
Keyword(s):  
Delivery System ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Vitro Release

Preparation, characterization, release kinetics, andin vitrocytotoxicity of calcium silicate cement as a risedronate delivery system

2013 ◽  
Vol 102 (7) ◽  
pp. 2295-2304 ◽  
Author(s):  
Tianxing Gong ◽  
Zhiqin Wang ◽  
Yubiao Zhang ◽  
Changshan Sun ◽  
Quanzu Yang ◽  
...  
Keyword(s):  
Delivery System ◽  
Calcium Silicate ◽  
Release Kinetics ◽  
Calcium Silicate Cement
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