scholarly journals Nitrogen-doped carbon nanodots for bioimaging and delivery of paclitaxel

2018 ◽  
Vol 6 (35) ◽  
pp. 5540-5548 ◽  
Author(s):  
I. Jennifer Gomez ◽  
Blanca Arnaiz ◽  
Michele Cacioppo ◽  
Francesca Arcudi ◽  
Maurizio Prato
Keyword(s):  
Drug Delivery ◽  
Anticancer Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Free Drug ◽  
Carbon Nanodots ◽  
Nitrogen Doped ◽  
Nitrogen Doped Carbon

A carbon nanodot–paclitaxel drug delivery system with enhanced anticancer activity as compared to the free drug is reported.

Dry Drops: a new preservative-free drug delivery system

1999 ◽  
Vol 237 (5) ◽  
pp. 394-398 ◽  
Author(s):  
M. Diestelhorst ◽  
S. Grunthal ◽  
R. Süverkrüp
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Free Drug ◽  
Preservative Free

Synthesis of fluorescent nitrogen-doped carbon dots from dried shrimps for cell imaging and boldine drug delivery system

RSC Advances ◽  
2016 ◽  
Vol 6 (15) ◽  
pp. 12169-12179 ◽  
Author(s):  
Stephanie L. D'souza ◽  
Balaji Deshmukh ◽  
Jigna R. Bhamore ◽  
Karuna A. Rawat ◽  
Nibedita Lenka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Carbon Dots ◽  
Human Breast ◽  
System P ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon ◽  
Mcf 7

Fluorescent N-doped carbon dots were synthesized using dried shrimps as precursors and rationally fabricated as a traceable drug delivery system for the targeted delivery of boldine to human breast cancer cells (MCF-7 cells).

Liposome as drug delivery system enhance anticancer activity of iridium (III) complex

2020 ◽  
pp. 1-14
Author(s):  
Yiying Gu ◽  
Lan Bai ◽  
Yuanyuan Zhang ◽  
Huiwen Zhang ◽  
Degang Xing ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Activity ◽  
Drug Delivery System ◽  
Delivery System

A Multi‐crosslinking Nanocapsule‐Based Serial‐Stimuli‐Responsive Leakage‐Free Drug‐Delivery System In Vitro

2019 ◽  
Vol 25 (56) ◽  
pp. 13017-13024
Author(s):  
Yazhou Liu ◽  
Tianjiao Shen ◽  
Congcong Gao ◽  
H. A. Abdulhadi El‐Ali ◽  
Na Gao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Free Drug ◽  
Stimuli Responsive

scholarly journals Folate-Conjugated Chitosan-Pluronic P123 Nanogels: Synthesis and Characterizations towards Dual Drug Delivery

2019 ◽  
Vol 2019 ◽  
pp. 1-14
Author(s):  
Van Toan Nguyen ◽  
Thi Hương Nguyen ◽  
Le Hang Dang ◽  
Hieu Vu-Quang ◽  
Ngoc Quyen Tran
Keyword(s):  
Drug Delivery ◽  
Anticancer Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Breast Cancer Cell Lines ◽  
Uniform Size ◽  
Pluronic P123 ◽  
Ic50 Value ◽  
Therapeutic Compounds ◽  
Dual Drug

In this study, a self-assembled nanogel-based pluronic P123-grafted chitosan-folate (CP-FA) was fabricated as a paclitaxel/curcumin codelivery system. 1H-NMR and TGA proved that the fabricating method of CP-FA was successful. Dynamic light scattering (DLS), zeta potentials, and transmission electron microscopy (TEM) exposed that CP-FA nanoparticles had a uniform size with a diameter of around 16.27±2.01 nm in the colloidal solution and had better sustainable stability at a lower concentration than P123 due to the moderate positive potential value (39.43±3.45 mV) and the lower critical micelle concentration (0.036 mg/ml). Dual drugs were loaded with CP-FA nanogels via self-assembly by the hydrophobic interaction between both hydrophobic therapeutic compounds (PTX and Cur) and the hydrophobic segment of the P123 copolymer. The high hydrophobicity of the segment induced a great loading efficacy of up to 98.63±0.42 of PTX and 97.82±0.48 of Cur. In addition, the CP-FA nanogels exposed superior effects in a controlled release of these encapsulated therapeutic compounds for a long period of time. The anticancer activity of the dual-drug delivery system was evaluated using human breast cancer cell lines (MCF-7) via the IC50 value to compare with the PTX-loading CP-FA nanogel. The obtained results suggested that CP-FA/PTX-Cur displayed a remarkable improvement in anticancer activity at an IC50 value of 5.74±0.23 nM which was higher than that of CP-FA/PTX (IC50=8.20±1.41 nM) due to the synergistic effect of both PTX and Cur. Thereby, a dual-drug delivery-system-based CP-FA of PTX and Cur has been proposed as a promising candidate in cancer therapy.

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