ChemInform Abstract: C-NUCLEOSIDES. II. SYNTHESIS OF DERIVATIVES OF 2-β-D-RIBOFURANOSYLBENZOTHIAZOLE, 5-β-D-RIBOFURANOSYLTETRAZOLE, AND 5-β-GLYCOSYL-1,3,4-OXADIAZOLE DERIVATIVES

1978 ◽  
Vol 9 (49) ◽  
Author(s):  
I. FARKAS ◽  
I. F. SZABO ◽  
R. BOGNAR ◽  
L. SILADI
Keyword(s):  
Oxadiazole Derivatives ◽  
Derivatives Of

Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Nalidixic Acid ◽  
Copper Complexes ◽  
Biological Activities ◽  
Bidentate Coordination ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Oxadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
Derivatives Of ◽  
Substituted 1

A series of novel 1, 3, 4-oxadiazole analogues was synthesized from cyclization of hydrazones of substituted 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazides were prepared from nalidixic acid. The structures of synthesized oxadiazole derivatives and their copper complexes were elucidated on the basis of FTIR, elemental analyses, 1H-NMR and atomic absorption spectral analysis. It was observed from spectral data that metal ligand ratio was 1:1 in all copper complexes and they were bidentate, coordination was found to be done through oxygen of 4-oxo group and nitrogen of oxadiazole ring. The synthesized compounds were further evaluated with biological activities and compared with parent hydrazones. Copper complexes possess antibacterial and antifungal activities better than the oxadiazoles while they have better antioxidant activity then copper complexes. Parent hydrazones were better in all biological activities than synthesized oxadiazoles.

Synthesis and characterization of novel 2,5-diphenyl-1,3,4-oxadiazole derivatives of anthracene and its application as electron transporting blue emitters in OLEDs

2011 ◽  
Vol 161 (9-10) ◽  
pp. 869-880 ◽  
Author(s):  
M. Ananth Reddy ◽  
G. Mallesham ◽  
Anup Thomas ◽  
Kola Srinivas ◽  
V. Jayathirtha Rao ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
Oxadiazole Derivatives ◽  
Blue Emitters ◽  
Derivatives Of

Chemical structure dependent electron transport in 9,10-bis(2-phenyl-1,3,4-oxadiazole) derivatives of anthracene

RSC Advances ◽  
2014 ◽  
Vol 4 (24) ◽  
pp. 12206 ◽  
Author(s):  
Arunandan Kumar ◽  
Priyanka Tyagi ◽  
M. Ananth Reddy ◽  
G. Mallesham ◽  
K. Bhanuprakash ◽  
...  
Keyword(s):  
Electron Transport ◽  
Chemical Structure ◽  
Oxadiazole Derivatives ◽  
Derivatives Of

Synthesis of some novel 1,2,4-triazole and 1,3,4-oxadiazole derivatives of biological interest

2012 ◽  
Vol 22 (7) ◽  
pp. 3341-3349 ◽  
Author(s):  
Bhimagouda S. Patil ◽  
G. Krishnamurthy ◽  
M. R. Lokesh ◽  
N. D. Shashikumar ◽  
H. S. Bhojya Naik ◽  
...  
Keyword(s):  
Biological Interest ◽  
Oxadiazole Derivatives ◽  
Derivatives Of

2,5-Disubstituted 1,3,4-oxadiazole derivatives of chromeno[4,3-b]pyridine: synthesis and study of antimicrobial potency

2016 ◽  
Vol 22 (3) ◽  
Author(s):  
Ghanshyam R. Jadhav ◽  
Dattatray G. Deshmukh ◽  
Vijay J. Medhane ◽  
Vishwas B. Gaikwad ◽  
Avinash D. Bholay
Keyword(s):  
Convenient Synthesis ◽  
Oxadiazole Derivatives ◽  
Derivatives Of ◽  
Antimicrobial Potency ◽  
Pyridine Synthesis

AbstractA convenient synthesis of 1,3,4-oxadiazole containing derivatives of chromeno[4,3-

scholarly journals New oxadiazole derivatives of isonicotinohydrazide in the search for antimicrobial agents: Synthesis and in vitro evaluation

2012 ◽  
Vol 77 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Manav Malhotra ◽  
Mohit Sanduja ◽  
Abdul Samad ◽  
Aakash Deep
Keyword(s):  
Antimicrobial Agents ◽  
Fungal Strain ◽  
Spectral Studies ◽  
Dilution Method ◽  
Mass Spectral ◽  
Oxadiazole Derivatives ◽  
Derivatives Of ◽  
And Staphylococcus Aureus

Structural modification of the front line antitubercular drug isoniazid provide a lipophilic adaptations of the drug in which hydrazide moiety of isoniazid is replaced by 1,3,4-oxadiazole heterocycles to eliminate in-vivo acetylation by arylamine N-acetyltransferase which results to form inactive acetylated drug. In the present study a series of sixteen oxadiazole derivatives were synthesized and characterized by (IR, 1H NMR, 13C NMR and Mass spectral) studies. All the synthesized compounds were evaluated for their antimicrobial activity by broth dilution method against two Gram positive strains (Bacillus subtilis and Staphylococcus aureus), two Gram negative strains (Pseudomonas aeruginosa and Escherichia coli) and fungal strain (Candida albicans and Aspergillus niger). The minimum inhibitory concentration of the compounds was in the range of 1.56-50 ?g ml-1 against bacterial and fungal strain. The results revealed that all synthesized compounds have a significant biological activity against the tested microorganisms. Among the synthesized derivatives 4g, 4h, 4m and 4p were found to be most effective antimicrobial compounds.

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