scholarly journals Development of Zn-ProPhenol-Catalyzed Asymmetric Alkyne Addition: Synthesis of Chiral Propargylic Alcohols

2012 ◽  
Vol 18 (51) ◽  
pp. 16498-16509 ◽  
Author(s):  
Barry M. Trost ◽  
Mark J. Bartlett ◽  
Andrew H. Weiss ◽  
Axel Jacobi von Wangelin ◽  
Vincent S. Chan
Keyword(s):  
Propargylic Alcohols ◽  
Alkyne Addition

A Lewis acid activated reaction of Zn with EtI to promote highly enantioselective alkyne additions to aldehydes

2015 ◽  
Vol 51 (2) ◽  
pp. 358-361 ◽  
Author(s):  
Shan-yong Chen ◽  
Winnie Liu ◽  
Xuedan Wu ◽  
Jun Ying ◽  
Xiaoqi Yu ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Propargylic Alcohols ◽  
Alkyne Addition

Zn powder and EtI in the presence of (S)-BINOL and Ti(OiPr)4 promote highly enantioselective alkyne addition to aldehydes at rt to generate chiral propargylic alcohols.

ChemInform Abstract: Development of Zn-ProPhenol-Catalyzed Asymmetric Alkyne Addition: Synthesis of Chiral Propargylic Alcohols.

ChemInform ◽  
2013 ◽  
Vol 44 (20) ◽  
pp. no-no
Author(s):  
Barry M. Trost ◽  
Mark J. Bartlett ◽  
Andrew H. Weiss ◽  
Axel Jacobi von Wangelin ◽  
Vincent S. Chan
Keyword(s):  
Propargylic Alcohols ◽  
Alkyne Addition

Remote C(sp3)–H vinylation via radical-mediated consecutive fission of C–H and C–C bonds

2020 ◽  
Vol 7 (19) ◽  
pp. 2981-2985
Author(s):  
Tao Niu ◽  
Shan Yang ◽  
Xinxin Wu ◽  
Chen Zhu
Keyword(s):  
Propargylic Alcohols

Described herein is a radical-mediated vinylation of the remote C(sp3)–H bonds of propargylic alcohols.

Gold Catalyzed Hydroamination of Propargylic Alcohols: Controlling Divergent Reaction Pathways to Access 1,3-Aminoalcohols, 3-Hydroxyketones or 3-Aminoketones

2018 ◽  
Author(s):  
Victor Laserna ◽  
Tom Sheppard
Keyword(s):  
Gold Catalysis ◽  
Reaction Pathways ◽  
High Yield ◽  
Reaction Conditions ◽  
Propargylic Alcohols ◽  
Catalytic Quantity ◽  
Selective Formation ◽  
General Method

A versatile approach to the valorization of propargylic alcohols is reported, enabling controlled access to three different products from the same starting materials. Firstly, a general method for the hydroamination of propargylic alcohols with anilines is described using gold catalysis to give 3-hydroxy imines with complete regioselectivity. These 3-hydroxyimines can be reduced to give 1,3-aminoalcohols with high syn seletivity. Alternatively, by using a catalytic quantity of aniline, 3-hydroxyketones can be obtained in high yield directly from propargylic alcohols. Further manipulation of the reaction conditions enables the selective formation of 3-aminoketones via a rearrangement/hydroamination pathway.<br>

Catalyst- and Additive-Free Cascade Phosphorylation/Cyclization of Propargylic Alcohols and R2P(O)OH

2021 ◽  
pp. 152761
Author(s):  
Yuxing Zhang ◽  
Xian-Rong Song ◽  
Fengyan Jin ◽  
Tao Yang ◽  
Ruchun Yang ◽  
...  
Keyword(s):  
Propargylic Alcohols

scholarly journals From Propargylic Alcohols to Substituted Thiochromenes: gem-Disubstituent Effect in Intramolecular Alkyne Iodo/hydroarylation

2021 ◽  
Author(s):  
Noelia Velasco ◽  
Anisley Suárez ◽  
Fernando Martínez-Lara ◽  
Manuel Ángel Fernández-Rodríguez ◽  
Roberto Sanz ◽  
...  
Keyword(s):  
Propargylic Alcohols
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