Efficient One-Pot Synthesis of N-Containing Heterocycles by Multicomponent Coupling of Silicon-Tethered Diynes, Nitriles, and Isocyanides through Intramolecular Cyclization of IminoacylZr Intermediates

2010 ◽  
Vol 16 (28) ◽  
pp. 8419-8426 ◽  
Author(s):  
Shaoguang Zhang ◽  
Wen-Xiong Zhang ◽  
Zhenfeng Xi
Keyword(s):  
Intramolecular Cyclization ◽  
One Pot ◽  
One Pot Synthesis ◽  
Multicomponent Coupling

scholarly journals A Synthesis of 4-Chloro-2-(trichloromethyl)pyrimidines and Their Study in Nucleophilic Substitution

Synthesis ◽  
2018 ◽  
Vol 51 (02) ◽  
pp. 530-537 ◽  
Author(s):  
Moisés Romero-Ortega ◽  
Michelle Trujillo-Lagunas ◽  
Ignacio Medina-Mercado ◽  
Ivann Zaragoza-Galicia ◽  
Horacio Olivo
Keyword(s):  
Nucleophilic Substitution ◽  
Intramolecular Cyclization ◽  
Nitrogen Heterocycles ◽  
Cyclization Reaction ◽  
Substitution Reactions ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Acyl Chlorides ◽  
Nucleophilic Substitution Reactions ◽  
One Pot Synthesis

A convenient two-step, one-pot synthesis of 4-chloro-2-(trichloromethyl)pyrimidines starting from 2-(trichloromethyl)-1,3-diazabutadienes is described. These nitrogen heterocycles were prepared by a sequential acylation/intramolecular cyclization reaction between 2-(trichloromethyl)-1,3-diazabutadienes and acyl chlorides in the presence of triethylamine followed by treatment with POCl3. This is the first report for the synthesis of this type of 4-chloro-2-(trichloromethyl)pyrimidine derivatives and serves as a source for a wide variety of other substituted pyrimidines by nucleophilic substitution reactions.

Expeditious Scalable Catalyst-Free One-Pot Synthesis of 4-Alkoxy-5-amino-3-methylthiophene-2-carbonitriles via Sequential Reactions­ of Lithiated Alkoxyallenes with Isothiocyanates and 2-Bromoacetonitrile

Synthesis ◽  
2018 ◽  
Vol 50 (09) ◽  
pp. 1891-1900 ◽  
Author(s):  
Nina Nedolya ◽  
Boris Trofimov ◽  
Olga Tarasova ◽  
Alexander Albanov
Keyword(s):  
Intramolecular Cyclization ◽  
Thiophene Ring ◽  
One Pot ◽  
One Pot Synthesis ◽  
Convenient Approach ◽  
Reaction Proceeds ◽  
Sequential Addition ◽  
In Situ Formation ◽  
Cyano Groups

A synthetically simple and convenient approach to tetrasubstituted thiophenes with rare combination of the alkoxy, amino, and cyano groups has been developed. The assembly of polyfunctionalized thiophene ring is implemented in one preparative step by sequential addition of isothiocyanate and 2-bromoacetonitrile to the lithiated (with n-BuLi) alkoxyallene. The reaction proceeds through in situ formation and intramolecular cyclization of cyanomethyl 2-alkoxy-N-buta-2,3-dienimidothioate (1-aza-1,3,4-triene).

A New Multicomponent Coupling of Aldehydes, Amides, and Dienophiles:  Atom-Efficient One-Pot Synthesis of Highly Substituted Cyclohexenes and Cyclohexadienes

2001 ◽  
Vol 123 (34) ◽  
pp. 8398-8399 ◽  
Author(s):  
Helfried Neumann ◽  
Axel Jacobi von Wangelin ◽  
Dirk Gördes ◽  
Anke Spannenberg ◽  
Matthias Beller
Keyword(s):  
One Pot ◽  
One Pot Synthesis ◽  
Multicomponent Coupling
Sign in / Sign up

Export Citation Format

Share Document