ChemInform Abstract: Tandem Retro-Michael Addition-Claisen Rearrangement-Intramolecular Cyclization: One-Pot Synthesis of Densely Functionalized Ethyl Dihydropyrimidine-4-carboxylates from Simple Building Blocks.

ChemInform ◽  
2008 ◽  
Vol 39 (28) ◽  
Author(s):  
B. Narasimhulu Naidu
Keyword(s):  
Intramolecular Cyclization ◽  
Michael Addition ◽  
Claisen Rearrangement ◽  
Building Blocks ◽  
One Pot ◽  
One Pot Synthesis

Reaction of Bromoenones with Amidines: A Simple Catalyst-Free Approach to Trifluoromethylated Pyrimidines

Synthesis ◽  
2020 ◽  
Vol 52 (10) ◽  
pp. 1512-1522
Author(s):  
Alexander Yu. Rulev ◽  
Alexey R. Romanov ◽  
Alexander V. Popov ◽  
Evgeniy V. Kondrashov ◽  
Sergey V. Zinchenko
Keyword(s):  
Intramolecular Cyclization ◽  
Michael Addition ◽  
High Selectivity ◽  
Reaction Path ◽  
Cascade Reactions ◽  
Trifluoromethyl Group ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
High Yields

A facile one-pot synthesis of trifluoromethylated pyrimidines has been achieved by the treatment of fluorinated 2-bromoenones with aryl- and alkylamidines. The assembly of pyrimidine core proceeds by the cascade reactions via aza-Michael addition–intramolecular cyclization–dehydrohalogenation/dehydration sequence. This strategy is featured by high selectivity and mild reaction conditions giving the target heterocycles in high yields (up to 99%). The unique influence of trifluoromethyl group on the reaction path is demonstrated.

Construction of Functionalized (Dihydro)thieno[2,3-c]chromene Derivatives via a Domino Michael Addition/Intramolecular Cyclization Reaction

Synthesis ◽  
2018 ◽  
Vol 50 (08) ◽  
pp. 1667-1674
Author(s):  
Jian-Wu Xie ◽  
Li-Si-Han Yu ◽  
Jian-Lian Dong ◽  
Zhi-Jian Gao ◽  
Jing Wang
Keyword(s):  
Intramolecular Cyclization ◽  
Michael Addition ◽  
Lewis Base ◽  
Cyclization Reaction ◽  
One Pot ◽  
One Pot Synthesis

A one-pot synthesis of substituted (dihydro)thieno[2,3-c]chromene derivatives was developed through a Lewis base catalyzed domino Michael addition/intramolecular cyclization reaction between 3-nitro-2H-chromenes and thioamides. The desired (dihydro)thieno[2,3-c]chromene derivatives were prepared with a large substrate scope (22 examples) and excellent diastereoselectivity in moderate to excellent yields.

Catalyst-Free One-Pot Synthesis of Novel Heteroarylamine Substituted Furo[3,2-c]coumarins

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1589-1592 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Mahnaz Saraei ◽  
Reyhaneh Khoeiniha
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Ring Closure ◽  
Dehydration Reaction ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Tandem Process ◽  
First Time

A high-yielding cyclocondensation of 4-hydroxycoumarin, phenylglyoxal monohydrate, and heteroarylamines proceeds without catalysis, which gives novel functionalized furo[3,2-c]coumarins and heteroarylamino alkylation of coumarin products in acetonitrile under reflux, is reported for the first time. This tandem process involves sequentially an aldol condensation, Michael addition, a ring closure, and dehydration reaction.

One-Pot Synthesis of Highly Substituted Allenylidene Derivatives via Palladium- or Nickel-Catalyzed Tandem Michael Addition-Cyclization Reaction

2009 ◽  
Vol 351 (1-2) ◽  
pp. 141-146 ◽  
Author(s):  
Yun Shi ◽  
Jing Huang ◽  
Yan-Fang Yang ◽  
Lu-Yong Wu ◽  
Yan-Ning Niu ◽  
...  
Keyword(s):  
Michael Addition ◽  
Cyclization Reaction ◽  
One Pot ◽  
One Pot Synthesis

A Highly Enantioselective One-Pot Synthesis of Spirolactones by an Organocatalyzed Michael Addition/Cyclization Sequence

2011 ◽  
Vol 50 (40) ◽  
pp. 9382-9385 ◽  
Author(s):  
Silvia Sternativo ◽  
Antonella Calandriello ◽  
Ferdinando Costantino ◽  
Lorenzo Testaferri ◽  
Marcello Tiecco ◽  
...  
Keyword(s):  
Michael Addition ◽  
One Pot ◽  
One Pot Synthesis
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