Stabilization of G-Quadruplex DNA with Platinum(II) Schiff Base Complexes: Luminescent Probe and Down-Regulation of c-mycOncogene Expression

2009 ◽  
Vol 15 (47) ◽  
pp. 13008-13021 ◽  
Author(s):  
Peng Wu ◽  
Dik-Lung Ma ◽  
Chung-Hang Leung ◽  
Siu-Cheong Yan ◽  
Nianyong Zhu ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Complexes ◽  
Luminescent Probe ◽  
Down Regulation ◽  
Quadruplex Dna ◽  
G Quadruplex

The effect of isomerism and other structural variations on the G-quadruplex DNA-binding properties of some nickel Schiff base complexes

2020 ◽  
Vol 49 (30) ◽  
pp. 10360-10379 ◽  
Author(s):  
Son Q. T. Pham ◽  
Christopher Richardson ◽  
Celine Kelso ◽  
Anthony C. Willis ◽  
Stephen F. Ralph
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Schiff Base Complexes ◽  
Structural Variations ◽  
Binding Properties ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Binding Properties ◽  
Binding Behaviour

Changing the position of pendant groups on nickel Schiff base complexes can alter their binding behaviour towards quadruplex DNA.

Flexible Ru II Schiff Base Complexes: G‐Quadruplex DNA Binding and Photo‐Induced Cancer Cell Death

2020 ◽  
Vol 26 (61) ◽  
pp. 13849-13860
Author(s):  
Martin Gillard ◽  
Justin Weynand ◽  
Hugues Bonnet ◽  
Frédérique Loiseau ◽  
Anabelle Decottignies ◽  
...  
Keyword(s):  
Cell Death ◽  
Schiff Base ◽  
Dna Binding ◽  
Cancer Cell ◽  
Schiff Base Complexes ◽  
Quadruplex Dna ◽  
Cancer Cell Death ◽  
G Quadruplex

The interaction of Schiff Base complexes of nickel(II) and zinc(II) with duplex and G-quadruplex DNA

2018 ◽  
Vol 178 ◽  
pp. 106-114 ◽  
Author(s):  
Riccardo Bonsignore ◽  
Fabrizia Russo ◽  
Alessio Terenzi ◽  
Angelo Spinello ◽  
Antonino Lauria ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Complexes ◽  
Quadruplex Dna ◽  
G Quadruplex

Effect of structure variations on the quadruplex DNA binding ability of nickel Schiff base complexes

2018 ◽  
Vol 47 (38) ◽  
pp. 13573-13591 ◽  
Author(s):  
Kimberley J. Davis ◽  
Nawal M. O. Assadawi ◽  
Son Q. T. Pham ◽  
Monica L. Birrento ◽  
Christopher Richardson ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Nickel Complexes ◽  
Schiff Base Complexes ◽  
Binding Ability ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
Effect Of Structure

The synthesis of two new series of nickel complexes is described, along with their ability to bind to duplex and quadruplex DNA structures.

G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes

2016 ◽  
Vol 161 ◽  
pp. 115-121 ◽  
Author(s):  
Riccardo Bonsignore ◽  
Alessio Terenzi ◽  
Angelo Spinello ◽  
Annamaria Martorana ◽  
Antonino Lauria ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Schiff Base Complexes ◽  
Duplex Dna ◽  
G Quadruplex

Computational studies on G-quadruplex DNA-stabilizing property of novel Wittig-based Schiff-Base ligands and their copper(II) complexes

2018 ◽  
Vol 30 (3) ◽  
pp. 727-742
Author(s):  
Bathula Rajasekhar ◽  
Chandan Kumar ◽  
G. Premkumar ◽  
Mohd Aamir Bin Riyaz ◽  
P. T. V. Lakshmi ◽  
...  
Keyword(s):  
Schiff Base ◽  
Computational Studies ◽  
Schiff Base Ligands ◽  
Quadruplex Dna ◽  
G Quadruplex

A new class of quadruplex DNA-binding nickel Schiff base complexes

2020 ◽  
Vol 49 (15) ◽  
pp. 4843-4860 ◽  
Author(s):  
Son Q. T. Pham ◽  
Nawal Assadawi ◽  
Jadon Wells ◽  
Reece A. Sophocleous ◽  
Kimberley J. Davis ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Cancer Cells ◽  
Schiff Base Complex ◽  
Schiff Base Complexes ◽  
Selective Binding ◽  
Quadruplex Dna ◽  
Base Complex ◽  
New Class ◽  
Binding Behaviour

A new nickel Schiff base complex shows selective binding behaviour towards quadruplex DNA and cytotoxicity against cancer cells.

Inducement of G-Quadruplex DNA Forming and Down-Regulation of OncogeneC-MYCby Bile Acid-Amino Acid Conjugate—BAA

2010 ◽  
Vol 29 (3) ◽  
pp. 190-199 ◽  
Author(s):  
Mingyue Tian ◽  
Xiufeng Zhang ◽  
Yan Li ◽  
Yong Ju ◽  
Junfeng Xiang ◽  
...  
Keyword(s):  
Bile Acid ◽  
Amino Acid ◽  
Down Regulation ◽  
Quadruplex Dna ◽  
Amino Acid Conjugate ◽  
G Quadruplex ◽  
Acid Conjugate

Some cationic porphyrins: synthesis, stabilization of G-quadruplexes, and down-regulation of c-myc in Hep G2 cells

2009 ◽  
Vol 13 (08n09) ◽  
pp. 865-875 ◽  
Author(s):  
Shao R. Wang ◽  
Dan Zhang ◽  
Feng L. Luo ◽  
Lin Liu ◽  
Xiao C. Weng ◽  
...  
Keyword(s):  
Cell Line ◽  
Binding Assays ◽  
Hep G2 ◽  
Hep G2 Cells ◽  
Telomeric Dna ◽  
Down Regulation ◽  
Cationic Porphyrins ◽  
Quadruplex Dna ◽  
Myc Oncogene ◽  
G Quadruplex

The stabilization of G-quadruplex DNA represents an attractive strategy for the design and development of novel antitumor drugs. In the present work, we have designed and synthesized nine cationic porphyrins, each with four side arms at their meso positions. The interactions of these porphyrins with both human telomeric DNA and NHE III1 G-quadruplexes were measured by various DNA binding assays, including polymerase stop assay, circular dichroism (CD) and CD melting assay. We then proceeded to investigate their effects on the expression of c-myc oncogene in the Hep G2 cell line. The experimental results indicate that these porphyrins are capable of effectively inducing or stabilizing both human telomeric and NHE III1 G-quadruplexes in the presence or absence of metal ions. Furthermore, we have discovered that porphyrins with a stronger stabilizing effect on c-myc G-quadruplexes lead to more pronounced down-regulation of the c-myc oncogene in the Hep G2 cell line.

9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc

2008 ◽  
Vol 16 (16) ◽  
pp. 7582-7591 ◽  
Author(s):  
Yan Ma ◽  
Tian-Miao Ou ◽  
Jin-Qiang Hou ◽  
Yu-Jing Lu ◽  
Jia-Heng Tan ◽  
...  
Keyword(s):  
Down Regulation ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Berberine Derivatives
Sign in / Sign up

Export Citation Format

Share Document