The effect of isomerism and other structural variations on the G-quadruplex DNA-binding properties of some nickel Schiff base complexes

2020 ◽  
Vol 49 (30) ◽  
pp. 10360-10379 ◽  
Author(s):  
Son Q. T. Pham ◽  
Christopher Richardson ◽  
Celine Kelso ◽  
Anthony C. Willis ◽  
Stephen F. Ralph
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Schiff Base Complexes ◽  
Structural Variations ◽  
Binding Properties ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Binding Properties ◽  
Binding Behaviour

Changing the position of pendant groups on nickel Schiff base complexes can alter their binding behaviour towards quadruplex DNA.

A new class of quadruplex DNA-binding nickel Schiff base complexes

2020 ◽  
Vol 49 (15) ◽  
pp. 4843-4860 ◽  
Author(s):  
Son Q. T. Pham ◽  
Nawal Assadawi ◽  
Jadon Wells ◽  
Reece A. Sophocleous ◽  
Kimberley J. Davis ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Cancer Cells ◽  
Schiff Base Complex ◽  
Schiff Base Complexes ◽  
Selective Binding ◽  
Quadruplex Dna ◽  
Base Complex ◽  
New Class ◽  
Binding Behaviour

A new nickel Schiff base complex shows selective binding behaviour towards quadruplex DNA and cytotoxicity against cancer cells.

scholarly journals Exploring the Interaction of Curaxin CBL0137 with G-Quadruplex DNA Oligomers

2021 ◽  
Vol 22 (12) ◽  
pp. 6476
Author(s):  
Sabrina Dallavalle ◽  
Luce M. Mattio ◽  
Roberto Artali ◽  
Loana Musso ◽  
Anna Aviñó ◽  
...  
Keyword(s):  
Dna Binding ◽  
31P Nmr ◽  
Antitumor Activities ◽  
Binding Properties ◽  
Dna Oligomers ◽  
Quadruplex Dna ◽  
Dna Targeting ◽  
G Quadruplex ◽  
Dna Binding Properties ◽  
Insight Into

Curaxins and especially the second-generation derivative curaxin CBL0137 have important antitumor activities in multiple cancers such as glioblastoma, melanoma and others. Although most of the authors suggest that their mechanism of action comes from the activation of p53 and inactivation of NF-kB by targeting FACT, there is evidence supporting the involvement of DNA binding in their antitumor activity. In this work, the DNA binding properties of curaxin CBL0137 with model quadruplex DNA oligomers were studied by 1H NMR, CD, fluorescence and molecular modeling. We provided molecular details of the interaction of curaxin with two G-quadruplex structures, the single repeat of human telomere d(TTAGGGT)4 and the c-myc promoter Pu22 sequence. We also performed 1H and 31P NMR experiments were also performed in order to investigate the interaction with duplex DNA models. Our data support the hypothesis that the interaction of curaxin with G-quadruplex may provide a novel insight into the DNA-binding properties of CBL0137, and it will be helpful for the design of novel selective DNA-targeting curaxin analogues.

Flexible Ru II Schiff Base Complexes: G‐Quadruplex DNA Binding and Photo‐Induced Cancer Cell Death

2020 ◽  
Vol 26 (61) ◽  
pp. 13849-13860
Author(s):  
Martin Gillard ◽  
Justin Weynand ◽  
Hugues Bonnet ◽  
Frédérique Loiseau ◽  
Anabelle Decottignies ◽  
...  
Keyword(s):  
Cell Death ◽  
Schiff Base ◽  
Dna Binding ◽  
Cancer Cell ◽  
Schiff Base Complexes ◽  
Quadruplex Dna ◽  
Cancer Cell Death ◽  
G Quadruplex

scholarly journals G-quadruplex binding properties of a potent PARP-1 inhibitor derived from 7-azaindole-1-carboxamide

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sabrina Dallavalle ◽  
Loana Musso ◽  
Roberto Artali ◽  
Anna Aviñó ◽  
Leonardo Scaglioni ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Parp Inhibition ◽  
Inhibition Mechanism ◽  
Binding Properties ◽  
Dna Oligomers ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Molecular Bases ◽  
Dna Binding Properties ◽  
Parp 1

AbstractPoly ADP-ribose polymerases (PARP) are key proteins involved in DNA repair, maintenance as well as regulation of programmed cell death. For this reason they are important therapeutic targets for cancer treatment. Recent studies have revealed a close interplay between PARP1 recruitment and G-quadruplex stabilization, showing that PARP enzymes are activated upon treatment with a G4 ligand. In this work the DNA binding properties of a PARP-1 inhibitor derived from 7-azaindole-1-carboxamide, (2-[6-(4-pyrrolidin-1-ylmethyl-phenyl)-pyrrolo[2,3-b]pyridin-1-yl]-acetamide, compound 1) with model duplex and quadruplex DNA oligomers were studied by NMR, CD, fluorescence and molecular modelling. We provide evidence that compound 1 is a strong G-quadruplex binder. In addition we provide molecular details of the interaction of compound 1 with two model G-quadruplex structures: the single repeat of human telomeres, d(TTAGGGT)4, and the c-MYC promoter Pu22 sequence. The formation of defined and strong complexes with G-quadruplex models suggests a dual G4 stabilization/PARP inhibition mechanism of action for compound 1 and provides the molecular bases of its therapeutic potential.

Effect of structure variations on the quadruplex DNA binding ability of nickel Schiff base complexes

2018 ◽  
Vol 47 (38) ◽  
pp. 13573-13591 ◽  
Author(s):  
Kimberley J. Davis ◽  
Nawal M. O. Assadawi ◽  
Son Q. T. Pham ◽  
Monica L. Birrento ◽  
Christopher Richardson ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Nickel Complexes ◽  
Schiff Base Complexes ◽  
Binding Ability ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
Effect Of Structure

The synthesis of two new series of nickel complexes is described, along with their ability to bind to duplex and quadruplex DNA structures.

G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes

2016 ◽  
Vol 161 ◽  
pp. 115-121 ◽  
Author(s):  
Riccardo Bonsignore ◽  
Alessio Terenzi ◽  
Angelo Spinello ◽  
Annamaria Martorana ◽  
Antonino Lauria ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Schiff Base Complexes ◽  
Duplex Dna ◽  
G Quadruplex
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