Novel Process Windows - Gates to Maximizing Process Intensification via Flow Chemistry

2009 ◽  
Vol 32 (11) ◽  
pp. 1641-1641 ◽  
Author(s):  
Volker Hessel
Keyword(s):  
Process Intensification ◽  
Flow Chemistry

scholarly journals Automated High-Pressure Atline Analysis of Photo-High-P,T Vitamin D3 Microfluidic Synthesis

2021 ◽  
Vol 3 ◽  
Author(s):  
Marc Escribà-Gelonch ◽  
Nghiep Nam Tran ◽  
Volker Hessel
Keyword(s):  
High Performance ◽  
Process Analytical Technology ◽  
Control Process ◽  
Process Intensification ◽  
Flow Chemistry ◽  
Critical Parameters ◽  
Primary Responsibility ◽  
Feasible Option ◽  
Relevant Topic ◽  
Pressure Independent

Process analytical technology has become a relevant topic in both industry and academia as a mechanism to control process quality by measuring critical parameters; being mainly applied in pharmaceutical industry. An emerging topic is process monitoring with subsequent process automation in flow chemistry using inline, online and atline analyzers. Flow chemistry often deliberately and favorably uses harsh conditions (termed Novel Process Windows) to achieve process intensification which raises the need for sampling under these conditions. This demands for setting in place a stabilization of the sample before exposing it to the processing. Ignoring this may result in being unable to use inline/online analytics and posing the need for a separation step before quantitative analysis, leaving atline analysis as the only feasible option. That means that sampling and connected operations need also to be automated. This is where this study sets in, and this is enabled by a modified high-performance liquid chromatography (HPLC) autosampler coupled to the photo-high-p,T flow synthesis of vitamin D3. It shows that sampling variables, such as decompression speed, can be even more critical in terms of variability of results than process variables such as concentration, pressure, and temperature. The modification enabled the autosampler fully automated and unattended sampling from the reactor and enabled pressure independent measurements with 89% accuracy, >95% reproducibility, and >96% repeatability, stating decompression speed as the primary responsibility for measurements’ uncertainty.

Process intensification using immobilized enzymes for the development of white biotechnology

2021 ◽  
Vol 11 (6) ◽  
pp. 1994-2020
Author(s):  
Harshada M. Salvi ◽  
Ganapati D. Yadav
Keyword(s):  
Ionic Liquids ◽  
Process Intensification ◽  
Flow Chemistry ◽  
Immobilized Enzymes ◽  
Hydrodynamic Cavitation ◽  
Future Directions ◽  
White Biotechnology

Process intensification of biocatalysed reactions using different techniques such as microwaves, ultrasound, hydrodynamic cavitation, ionic liquids, microreactors and flow chemistry in various industries is critically analysed and future directions provided.

Green Enabling Technologies for Competitive Synthesis of Pharmaceutical Lead Compounds

2020 ◽  
Vol 26 (44) ◽  
pp. 5700-5712
Author(s):  
Silvia Tagliapietra ◽  
Arianna Binello ◽  
Fabio Bucciol ◽  
Vladimir Trukhan ◽  
Mariachiara Colia ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Process Intensification ◽  
Flow Chemistry ◽  
Reaction Rates ◽  
Chemical Library ◽  
Production Chain ◽  
Enabling Technologies ◽  
Slow Kinetics ◽  
Drug Synthesis ◽  
Pharmaceutical Production

Combinations of different technologies are at the heart of the development and implementation of new, innovative processes and approaches for Industry 4.0 in the field of medicinal chemistry and drug discovery. Process intensification and advances in high-throughput synthetic techniques can dramatically improve reaction rates in processes for which slow kinetics represents a bottleneck. Easier access to target-based chemical library collections offers wider access to new leads for drug development. Green enabling technologies are a reliable ally for the design of environmentally friendly synthetic processes and more highly competitive pharmaceutical production. Mechanochemistry, microwaves, ultrasound and flow chemistry are mature techniques that can boast drug synthesis when properly integrated into the production chain. In this review, we selected examples from the literature of the last five years related to medicinal chemistry.

Surfactant free synthesis of monodisperse styrenic nanoparticle colloids via flow chemistry

2020 ◽  
Author(s):  
Marta Antoniv ◽  
Shitong Zhu ◽  
Sehoon Chang ◽  
Nouf AlJabri
Keyword(s):  
Flow Chemistry

Scalable Synthesis of Functionalized Ferrocenyl Azides and Amines Enabled by Flow Chemistry

2019 ◽  
Author(s):  
Merlin Kleoff ◽  
Johannes Schwan ◽  
Lisa Boeser ◽  
Bence Hartmayer ◽  
Mathias Christmann ◽  
...  
Keyword(s):  
Reaction Time ◽  
Heterogeneous Reaction ◽  
Reduction Process ◽  
Flow Chemistry ◽  
Subsequent Reaction ◽  
Scalable Synthesis ◽  
High Yields ◽  
Reactor Section

A scalable access to functionalized 1,1’- and 1,2-ferrocenyl azides has been realized in flow. By halogen‒lithium exchange of ferrocenyl halides and subsequent reaction with tosyl azide, a variety of functionalized ferrocenyl azides was obtained in high yields. To allow a scalable preparation of these potentially explosive compounds, an efficient flow protocol was developed accelerating the reaction time to minutes and circumventing accumulation of potentially hazardous intermediates. Switching from homogeneous to triphasic flow amidst process was key for handling a heterogeneous reaction mixture formed after a heated reactor section. The corresponding and synthetically versatile ferrocenyl amines were then prepared by a reliable reduction process.

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