Dopaminergic cells, derived from a high efficiency differentiation protocol from umbilical cord derived mesenchymal stem cells, alleviate symptoms in a Parkinson's disease rodent model

2013 ◽  
Vol 37 (2) ◽  
pp. 167-180 ◽  
Author(s):  
Prathibha Shetty ◽  
Anirban M. Thakur ◽  
Chandra Viswanathan
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
High Efficiency ◽  
Rodent Model ◽  
Dopaminergic Cells ◽  
Differentiation Protocol

scholarly journals Human Umbilical Cord Matrix Stem Cells: Preliminary Characterization and Effect of Transplantation in a Rodent Model of Parkinson's Disease

Stem Cells ◽  
2006 ◽  
Vol 24 (3) ◽  
pp. 781-792 ◽  
Author(s):  
Mark L. Weiss ◽  
Satish Medicetty ◽  
Amber R. Bledsoe ◽  
Raja Shekar Rachakatla ◽  
Michael Choi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Umbilical Cord ◽  
Rodent Model ◽  
Human Umbilical Cord ◽  
Preliminary Characterization ◽  
Umbilical Cord Matrix

scholarly journals Human Umbilical Cord Mesenchymal Stem Cells Infected with Adenovirus ExpressingHGFPromote Regeneration of Damaged Neuron Cells in a Parkinson’s Disease Model

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Xin-Shan Liu ◽  
Jin-Feng Li ◽  
Shan-Shan Wang ◽  
Yu-Tong Wang ◽  
Yu-Zhen Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Calcium Binding ◽  
Cell Model ◽  
Disease Model ◽  
Neuroblastoma Cells ◽  
Human Umbilical Cord

Parkinson’s disease (PD) is a neurodegenerative movement disorder that is characterized by the progressive degeneration of the dopaminergic (DA) pathway. Mesenchymal stem cells derived from human umbilical cord (hUC-MSCs) have great potential for developing a therapeutic agent as such. HGF is a multifunctional mediator originally identified in hepatocytes and has recently been reported to possess various neuroprotective properties. This study was designed to investigate the protective effect of hUC-MSCs infected by an adenovirus carrying theHGFgene on the PD cell model induced by MPP+ on human bone marrow neuroblastoma cells. Our results provide evidence that the cultural supernatant from hUC-MSCs expressing HGF could promote regeneration of damaged PD cells at higher efficacy than the supernatant from hUC-MSCs alone. And intracellular free Ca2+obviously decreased after treatment with cultural supernatant from hUC-MSCs expressing HGF, while the expression of CaBP-D28k, an intracellular calcium binding protein, increased. Therefore our study clearly demonstrated that cultural supernatant of MSC overexpressingHGFwas capable of eliciting regeneration of damaged PD model cells. This effect was probably achieved through the regulation of intracellular Ca2+levels by modulating of CaBP-D28k expression.

Transplantation of porcine umbilical cord matrix mesenchymal stem cells in a mouse model of Parkinson's disease

2011 ◽  
Vol 7 (3) ◽  
pp. 169-182 ◽  
Author(s):  
Eun-Ju Kang ◽  
Young-Hyurk Lee ◽  
Min-Jeong Kim ◽  
Yeon-Mi Lee ◽  
B. Mohana Kumar ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Umbilical Cord ◽  
Umbilical Cord Matrix

Effect of Human Umblical Cord Blood Stem Cells on a Rodent Model of Parkinson's Disease

2018 ◽  
Vol 46 (2) ◽  
pp. 117-127
Author(s):  
Somia Abd-Allah ◽  
El-Sayed Abdel-Aziz ◽  
Sabry Ali ◽  
Gamal El-Din Shams ◽  
Hesham Mohammed ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Cord Blood ◽  
Rodent Model ◽  
Blood Stem Cells ◽  
Cord Blood Stem Cells

Intranasal administration of endometrial mesenchymal stem cells as a suitable approach for Parkinson’s disease therapy

2019 ◽  
Vol 46 (4) ◽  
pp. 4293-4302 ◽  
Author(s):  
Saeid Bagheri-Mohammadi ◽  
Behrang Alani ◽  
Mohammad Karimian ◽  
Rana Moradian-Tehrani ◽  
Mahdi Noureddini
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Intranasal Administration ◽  
Disease Therapy
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