scholarly journals Front Cover: DNA‐Nanoscaffold‐Assisted Selection of Femtomolar Bivalent Human α‐Thrombin Aptamers with Potent Anticoagulant Activity (ChemBioChem 19/2019)

ChemBioChem ◽  
2019 ◽  
Vol 20 (19) ◽  
pp. 2420-2420
Author(s):  
Yu Zhou ◽  
Xiaodong Qi ◽  
Yan Liu ◽  
Fei Zhang ◽  
Hao Yan
Keyword(s):  
Anticoagulant Activity ◽  
Front Cover ◽  
Selection Of

DNA‐Nanoscaffold‐Assisted Selection of Femtomolar Bivalent Human α‐Thrombin Aptamers with Potent Anticoagulant Activity

ChemBioChem ◽  
2019 ◽  
Vol 20 (19) ◽  
pp. 2494-2503 ◽  
Author(s):  
Yu Zhou ◽  
Xiaodong Qi ◽  
Yan Liu ◽  
Fei Zhang ◽  
Hao Yan
Keyword(s):  
Anticoagulant Activity ◽  
Selection Of

scholarly journals Aptamers selection for platelets using droplet digital PCR

2021 ◽  
pp. 100-103
Author(s):  
A.V. Blagodatova ◽  
◽  
K.V. Kochkina ◽  
M.A. Komarova ◽  
N.Y. Trofina ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Anticoagulant Activity ◽  
Digital Pcr ◽  
Droplet Digital Pcr ◽  
Platelet Glycoprotein ◽  
Systematic Evolution ◽  
Selection For ◽  
Exponential Enrichment ◽  
Selection Of

The aim of the research. To obtain aptamers-inhibitors of platelet glycoprotein IIb / IIIa receptors, blocking platelet aggregation. Material and methods. Th e selection of aptamers for IIb / IIIa receptors of platelets was carried out according to the SELEX method (Systematic Evolution of Ligands by Exponential Enrichment), modifi ed to select aptamers for a specifi c epitope. Th e method allows selection and in vitro evolution of aptamers with selectivity to a specifi c target from a large library of oligonucleotides. Th e affi nity of aptamers for platelet IIb / IIIa receptors was determined using fl ow cytometry. Results. Pools of aptamers of aptamers with high affi nity for IIb / IIIa platelet receptors were obtained. Th e study of the antiaggregation properties of the pools with the best binding showed that platelet aggregation was minimal when using the aptamers from the pool of the 5th round of selection. Th us, the aptamers of this pool have the greatest potential to be used as an analogue of a synthetic peptide that blocks thromboaggregation. Aptamers from this pool were taken for sequencing in order to obtain sequences of aptamers with the best antiaggregatory properties. Conclusion. Pools of aptamers with high affi nity for IIb / IIIa receptors of platelets and anticoagulant activity were obtained.

scholarly journals Front Cover: A Thermodynamic Approach for Selection of Anodizing Electrolytes in Aluminium‐Holmium System (ChemElectroChem 6/2020)

2020 ◽  
Vol 7 (6) ◽  
pp. 1286-1286
Author(s):  
Khurram Shahzad ◽  
Cezarina Cela Mardare ◽  
Andrei Ionut Mardare ◽  
Achim Walter Hassel
Keyword(s):  
Thermodynamic Approach ◽  
Front Cover ◽  
Selection Of

scholarly journals Zebra Stripes Go Head to Toe by. S. & S. Shapiro

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Leslie Aitken
Keyword(s):  
Picture Books ◽  
Primary Grades ◽  
Building Blocks ◽  
Small Problem ◽  
Front Cover ◽  
University Of Alberta ◽  
Spatial Understanding ◽  
Parallel Lines ◽  
The University ◽  
Selection Of

Shapiro, Sheryl and Simon Shapiro.  Zebra Stripes Go Head to Toe.  Toronto: Annick Press, 2013. Print.The truth must be stated: the cover of this title aroused false hope in one particular five-year-old.  Selecting it from a proffered array of picture books, he cried, “I want a story about a zebra!”  It wasn’t. Still, it was a beautifully illustrated introduction to geometric shapes and terms: squares, cubes, and (mostly parallel) lines. The Shapiros build concepts with colorful and distinct examples that are quite within the experience, real or vicarious, of children.  We see building blocks, crosswalks, and, yes, the striped patterning of the zebra on the front cover.  The text, a series of rhyming couplets, is both playful and informative.  The font is very suitable for kindergarten or primary grades.  Undoubtedly, the book can be used to develop a child’s spatial understanding and linguistic precision.What then to do about that not so small problem: the dashed hopes that arise when a book that promises to be about a zebra turns out to be a math text?  Next time, this reviewer will preface its offering with a statement of fact: “This book can make arithmetic fun.”Recommended: 3 out of 4 stars Reviewer: Leslie AitkenLeslie Aitken’s long career in librarianship involved selection of children’s literature for school, public, special, and university collections.  She is a former Curriculum Librarian at the University of Alberta.

Cognitive gadgets and cognitive priors

2019 ◽  
Vol 42 ◽  
Author(s):  
Gian Domenico Iannetti ◽  
Giorgio Vallortigara
Keyword(s):  
Cognitive Neuroscience ◽  
Selection Of

Abstract Some of the foundations of Heyes’ radical reasoning seem to be based on a fractional selection of available evidence. Using an ethological perspective, we argue against Heyes’ rapid dismissal of innate cognitive instincts. Heyes’ use of fMRI studies of literacy to claim that culture assembles pieces of mental technology seems an example of incorrect reverse inferences and overlap theories pervasive in cognitive neuroscience.

Note on Selection of Coordinate Systems for Geodynamics

1975 ◽  
Vol 26 ◽  
pp. 395-407
Author(s):  
S. Henriksen
Keyword(s):  
Sea Level ◽  
The Other ◽  
Coordinate Systems ◽  
Mean Sea Level ◽  
The Earth ◽  
The One ◽  
Static Systems ◽  
Selection Of

The first question to be answered, in seeking coordinate systems for geodynamics, is: what is geodynamics? The answer is, of course, that geodynamics is that part of geophysics which is concerned with movements of the Earth, as opposed to geostatics which is the physics of the stationary Earth. But as far as we know, there is no stationary Earth – epur sic monere. So geodynamics is actually coextensive with geophysics, and coordinate systems suitable for the one should be suitable for the other. At the present time, there are not many coordinate systems, if any, that can be identified with a static Earth. Certainly the only coordinate of aeronomic (atmospheric) interest is the height, and this is usually either as geodynamic height or as pressure. In oceanology, the most important coordinate is depth, and this, like heights in the atmosphere, is expressed as metric depth from mean sea level, as geodynamic depth, or as pressure. Only for the earth do we find “static” systems in use, ana even here there is real question as to whether the systems are dynamic or static. So it would seem that our answer to the question, of what kind, of coordinate systems are we seeking, must be that we are looking for the same systems as are used in geophysics, and these systems are dynamic in nature already – that is, their definition involvestime.

Measurements of the Cape Astrometric Survey of the Southern Hemisphere

1978 ◽  
Vol 48 ◽  
pp. 515-521
Author(s):  
W. Nicholson
Keyword(s):  
Southern Hemisphere ◽  
Automatic Measuring ◽  
Measuring Machine ◽  
Final Selection ◽  
Selection Of

SummaryA routine has been developed for the processing of the 5820 plates of the survey. The plates are measured on the automatic measuring machine, GALAXY, and the measures are subsequently processed by computer, to edit and then refer them to the SAO catalogue. A start has been made on measuring the plates, but the final selection of stars to be made is still a matter for discussion.

Application of Improved Voltage Compensation in the SEM to Imaging of Organic Materials

1973 ◽  
Vol 31 ◽  
pp. 444-445
Author(s):  
P.J. Killingworth ◽  
M. Warren
Keyword(s):  
Electron Beam ◽  
Organic Materials ◽  
Operating Parameters ◽  
Low Density ◽  
Beam Diameter ◽  
Incident Electron Beam ◽  
Specimen Material ◽  
Voltage Compensation ◽  
Selection Of ◽  
Scanning Electron

Ultimate resolution in the scanning electron microscope is determined not only by the diameter of the incident electron beam, but by interaction of that beam with the specimen material. Generally, while minimum beam diameter diminishes with increasing voltage, due to the reduced effect of aberration component and magnetic interference, the excited volume within the sample increases with electron energy. Thus, for any given material and imaging signal, there is an optimum volt age to achieve best resolution.In the case of organic materials, which are in general of low density and electric ally non-conducting; and may in addition be susceptible to radiation and heat damage, the selection of correct operating parameters is extremely critical and is achiev ed by interative adjustment.

Selection and Preparation of Specific Tissue Regions For Tem Using Large Epoxy-Embedded Blocks

1973 ◽  
Vol 31 ◽  
pp. 324-325 ◽  
Author(s):  
P. M. Lowrie ◽  
W. S. Tyler
Keyword(s):  
Electron Microscopy ◽  
Anatomical Structures ◽  
Ultrastructural Studies ◽  
Transmission Electron ◽  
Microscopic Evaluation ◽  
Embedded Blocks ◽  
Specific Tissue ◽  
Definition Of ◽  
Areas Of Interest ◽  
Selection Of

The importance of examining stained 1 to 2μ plastic sections by light microscopy has long been recognized, both for increased definition of many histologic features and for selection of specimen samples to be used in ultrastructural studies. Selection of specimens with specific orien ation relative to anatomical structures becomes of critical importance in ultrastructural investigations of organs such as the lung. The uantity of blocks necessary to locate special areas of interest by random sampling is large, however, and the method is lacking in precision. Several methods have been described for selection of specific areas for electron microscopy using light microscopic evaluation of paraffin, epoxy-infiltrated, or epoxy-embedded large blocks from which thick sections were cut. Selected areas from these thick sections were subsequently removed and re-embedded or attached to blank precasted blocks and resectioned for transmission electron microscopy (TEM).

The DQE of an electron image recording system

1978 ◽  
Vol 36 (1) ◽  
pp. 100-101
Author(s):  
K.-H. Herrmann ◽  
D. Krahl ◽  
H.-P Rust
Keyword(s):  
Primary Electron ◽  
Ideal Case ◽  
Image Recording ◽  
Main Requirement ◽  
High Detection ◽  
Electron Image ◽  
Video Amplifier ◽  
Detection Quantum Efficiency ◽  
Selection Of ◽  
The Ideal

The high detection quantum efficiency (DQE) is the main requirement for an imagerecording system used in electron microscopy of radiation-sensitive specimens. An electronic TV system of the type shown in Fig. 1 fulfills these conditions and can be used for either analog or digital image storage and processing [1], Several sources of noise may reduce the DQE, and therefore a careful selection of various elements is imperative.The noise of target and of video amplifier can be neglected when the converter stages produce sufficient target electrons per incident primary electron. The required gain depends on the type of the tube and also on the type of the signal processing chosen. For EBS tubes, for example, it exceeds 10. The ideal case, in which all impinging electrons create uniform charge peaks at the target, is not obtainable for several reasons, and these will be discussed as they relate to a system with a scintillator, fiber-optic and photo-cathode combination as the first stage.

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