Synthesis and Immunological Properties of a Tetrasaccharide Portion of the B Side Chain of Rhamnogalacturonan II (RG-II)

ChemBioChem ◽  
2008 ◽  
Vol 9 (3) ◽  
pp. 381-388 ◽  
Author(s):  
Yu Rao ◽  
Therese Buskas ◽  
Anathea Albert ◽  
Malcolm A. O'Neill ◽  
Michael G. Hahn ◽  
...  
Keyword(s):  
Side Chain ◽  
Immunological Properties ◽  
Rhamnogalacturonan Ii

Structural characterization of the pectic polysaccharide rhamnogalacturonan II: evidence for the backbone location of the aceric acid-containing oligoglycosyl side chain

2000 ◽  
Vol 326 (4) ◽  
pp. 277-294 ◽  
Author(s):  
Stéphane Vidal ◽  
Thierry Doco ◽  
Pascale Williams ◽  
Patrice Pellerin ◽  
William S. York ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Side Chain ◽  
Pectic Polysaccharide ◽  
Rhamnogalacturonan Ii

Primary structure of the 2-O-methyl-α-l-fucose-containing side chain of the pectic polysaccharide, rhamnogalacturonan II

2003 ◽  
Vol 338 (4) ◽  
pp. 341-352 ◽  
Author(s):  
John N Glushka ◽  
Mark Terrell ◽  
William S York ◽  
Malcolm A O'Neill ◽  
Angela Gucwa ◽  
...  
Keyword(s):  
Primary Structure ◽  
Side Chain ◽  
Pectic Polysaccharide ◽  
Rhamnogalacturonan Ii

scholarly journals Products of aminolysis and enzymic hydrolysis of the cephalosporins

1970 ◽  
Vol 116 (3) ◽  
pp. 371-384 ◽  
Author(s):  
J. M. T. Hamilton-Miller ◽  
G. G. F. Newton ◽  
E. P. Abraham
Keyword(s):  
Amino Acids ◽  
Aqueous Solutions ◽  
Physical Properties ◽  
Side Chain ◽  
Enzymic Hydrolysis ◽  
Weakly Alkaline ◽  
Immunological Properties ◽  
Amino Compounds ◽  
Lactam Ring ◽  
Hydrolysis Of

1. The reaction of cephalosporins with ammonia, amino acids and other simple amino compounds in weakly alkaline aqueous solutions yields labile compounds with λmax. 230nm. The reaction of deacetyl- and deacetoxy-cephalosporins under similar conditions yields compounds with λmax. 260nm. 2. Hydrolysis with a β-lactamase results in the formation of compounds with λmax. 230nm from deacetylcephalosporins and cephalosporins, but not from deacetoxycephalosporins. 3. These different compounds decompose to give penaldates and penamaldates derived from the side chain and the carbon atoms of the β-lactam ring. 4. Derivatives similar to those obtained with simple amino compounds appear to be formed when cephalosporins and their analogues react with lysine polymers. 5. Some of the chemical and physical properties of the various derivatives have been studied and tentative structures for them are proposed. 6. Possible implications of the results in relation to the immunological properties of the cephalosporins are discussed.

Electroluminescent properties of side-chain naphthalimide-derivated polymers

1998 ◽  
Vol 95 (6) ◽  
pp. 1351-1354 ◽  
Author(s):  
C.-M. Bouché ◽  
P. Le Barny ◽  
H. Facoetti ◽  
F. Soyer ◽  
P. Robin
Keyword(s):  
Side Chain

Evidence for Impaired Hepatic Vitamin K1 Metabolism in Patients Treated with N-Methyl-Thiotetrazole Cephalosporins

1984 ◽  
Vol 51 (03) ◽  
pp. 358-361 ◽  
Author(s):  
H Bechtold ◽  
K Andrassy ◽  
E Jähnchen ◽  
J Koderisch ◽  
H Koderisch ◽  
...  
Keyword(s):  
Protein C ◽  
Oral Intake ◽  
Bleeding Complications ◽  
Side Chain ◽  
Acute Administration ◽  
Vitamin K1 ◽  
New Class ◽  
Parenteral Alimentation ◽  
Hepatocellular Regeneration ◽  
Echis Carinatus

SummaryIn 8 patients on no oral intake and with parenteral alimentation, administration of cephalosporins with N-methyl-thiotetrazole side chain (moxalactam, cefamandole), was associated with prolongation of prothrombin time, appearance in the circulation of descarboxy-prothrombin (counter immunoelectrophoresis and echis carinatus assay) and diminution of protein C. Acute administration of 10 mg vitamin Ki was followed by the transient appearance of vitamin K1 2,3-epoxide, indicating an impaired hepatocellular regeneration of vitamin K1 from the epoxide. Impaired hepatic vitamin K1 metabolism, tentatively ascribed to the N-methyl-thiotetrazole group, is one (but possibly not the only) cause of bleeding complications and depression of vitamin K1dependent procoagulants in patients treated with the new class of cephalosporins.

METABOLISM OF 17α-HYDROXYPROGESTERONE-4-14C-17α-CAPROATE BY HOMOGENATES OF RAT LIVER AND HUMAN PLACENTA

1961 ◽  
Vol 36 (4) ◽  
pp. 511-519 ◽  
Author(s):  
Margaret Wiener ◽  
Charles I. Lupa ◽  
E. Jürgen Plotz
Keyword(s):  
Rat Liver ◽  
Human Placenta ◽  
Steric Hindrance ◽  
Placental Tissue ◽  
Caproic Acid ◽  
Major Product ◽  
Side Chain ◽  
Anaerobic Conditions ◽  
Prolonged Action ◽  
Long Acting

ABSTRACT 17α-hydroxyprogesterone-4-14C-17α-caproate (HPC), a long-acting progestational agent, was incubated with homogenates of rat liver and human placenta. The rat liver was found to reduce Ring A of HPC under anaerobic conditions to form allopregnane-3β,17α-diol-20-one-17α-caproate and pregnane-3β,17α-diol-20-one-17α-caproate, the allopregnane isomer being the major product. The caproic acid ester was neither removed nor altered during the incubation. Placental tissue did not attack HPC under conditions where the 20-ketone of progesterone was reduced. It is postulated that this absence of attack on the side chain is due to steric hindrance from the caproate ester, and that this may account for the prolonged action of HPC.

P450 side-chain cleavage enzyme autoantibodies in canine Addison's disease

2013 ◽  
pp. 1-1
Author(s):  
Alisdair Boag ◽  
Kerry McLaughlin ◽  
Mike Christie ◽  
Peter Graham ◽  
Harriet Syme ◽  
...  
Keyword(s):  
Addison’S Disease ◽  
Side Chain ◽  
Addison's Disease ◽  
Side Chain Cleavage ◽  
Chain Cleavage ◽  
Cleavage Enzyme
Sign in / Sign up

Export Citation Format

Share Document