scholarly journals Synthesis of a 2,3,4-Triglycosylated Rhamnoside Fragment of Rhamnogalacturonan-II Side Chain A Using a Late Stage Oxidation Approach.

ChemInform ◽  
2005 ◽  
Vol 36 (23) ◽  
Author(s):  
Anne-Laure Chauvin ◽  
Sergey A. Nepogodiev ◽  
Robert A. Field
Keyword(s):  
Late Stage ◽  
Side Chain ◽  
Rhamnogalacturonan Ii

scholarly journals Peptide late-stage C(sp3)–H arylation by native asparagine assistance without exogenous directing groups

2020 ◽  
Vol 11 (34) ◽  
pp. 9290-9295 ◽  
Author(s):  
Yiyi Weng ◽  
Xingxing Ding ◽  
João C. A. Oliveira ◽  
Xiaobin Xu ◽  
Nikolaos Kaplaneris ◽  
...  
Keyword(s):  
Efficient Method ◽  
Late Stage ◽  
Side Chain ◽  
Directing Group

An efficient method for peptide late-stage C(sp3)-H arylations assisted by unmodified side chain of asparagine (Asn) without any exogenous directing group has been reported.

Synthesis and Immunological Properties of a Tetrasaccharide Portion of the B Side Chain of Rhamnogalacturonan II (RG-II)

ChemBioChem ◽  
2008 ◽  
Vol 9 (3) ◽  
pp. 381-388 ◽  
Author(s):  
Yu Rao ◽  
Therese Buskas ◽  
Anathea Albert ◽  
Malcolm A. O'Neill ◽  
Michael G. Hahn ◽  
...  
Keyword(s):  
Side Chain ◽  
Immunological Properties ◽  
Rhamnogalacturonan Ii

Structural characterization of the pectic polysaccharide rhamnogalacturonan II: evidence for the backbone location of the aceric acid-containing oligoglycosyl side chain

2000 ◽  
Vol 326 (4) ◽  
pp. 277-294 ◽  
Author(s):  
Stéphane Vidal ◽  
Thierry Doco ◽  
Pascale Williams ◽  
Patrice Pellerin ◽  
William S. York ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Side Chain ◽  
Pectic Polysaccharide ◽  
Rhamnogalacturonan Ii

Tryptophan N 1-Alkylation: Quick and Simple Access to Diversely Substituted Tryptophans

Synthesis ◽  
2021 ◽  
Author(s):  
Lukas Junk ◽  
Emanuel Papadopoulos ◽  
Uli Kazmaier
Keyword(s):  
Amino Acid ◽  
Late Stage ◽  
Side Chain ◽  
Free Access ◽  
Pharmaceutical Applications ◽  
Tryptophan Derivatives

AbstractThe diversification of amino acid sidechains is a major challenge in the synthesis and derivatization of peptides for pharmaceutical applications. We herein present a new protocol to alkylate the indole-nitrogen (N1) of N α-protected tryptophans. This method provides quick and epimerization-free access to tryptophan derivatives, which can directly be incorporated into peptides. Depending on the functionalities introduced in the side chain, different options for the late-stage modification of peptides are possible.

scholarly journals Synthesis and late stage modifications of Cyl-derivatives

2021 ◽  
Author(s):  
Phil Servatius ◽  
Uli Kazmaier
Keyword(s):  
Amino Acid ◽  
Late Stage ◽  
Histone Deacetylases ◽  
Claisen Rearrangement ◽  
Hdac Inhibitors ◽  
Direct Access ◽  
Side Chain ◽  
Amino Acid Side Chain ◽  
Naturally Occurring ◽  
Unsaturated Amino Acid

A peptide Claisen rearrangement is used as key step to generate a tetrapeptide with a C-terminal double unsaturated side chain. Activation and cyclization give direct access to cyclopeptides related to naturally occurring histone deacetylases (HDAC) inhibitors Cyl-1 and Cyl-2. Late stage modifications on the unsaturated amino acid side chain allow the introduction of functionalities which might coordinate to metal ions in the active center of metalloproteins, such as histone deacetylases.

Primary structure of the 2-O-methyl-α-l-fucose-containing side chain of the pectic polysaccharide, rhamnogalacturonan II

2003 ◽  
Vol 338 (4) ◽  
pp. 341-352 ◽  
Author(s):  
John N Glushka ◽  
Mark Terrell ◽  
William S York ◽  
Malcolm A O'Neill ◽  
Angela Gucwa ◽  
...  
Keyword(s):  
Primary Structure ◽  
Side Chain ◽  
Pectic Polysaccharide ◽  
Rhamnogalacturonan Ii

Enantioselective total synthesis of (+)-ieodomycin A, (+)-ieodomycin B, and their three stereoisomers

2020 ◽  
Author(s):  
Du-Bong Choi ◽  
Hansol Choi ◽  
Jihoon Lee ◽  
Yeon-Ju Lee ◽  
Hyi-Seung Lee ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Late Stage ◽  
Side Chain ◽  
Enantioselective Total Synthesis

Enantioselective routes for the total synthesis of ieodomycins A & B, and three stereochemical analogues of ieodomycin B via a late-stage elaboration of the side chain.

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