Synthesis and antimicrobial activity of ursolic acid ester derivatives

2021 ◽  
Author(s):  
Vinicius Viana Pereira ◽  
Nara Rúbia Pereira ◽  
Rafael César Gonçalves Pereira ◽  
Lucienir Pains Duarte ◽  
Jacqueline Aparecida Takahashi ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Ursolic Acid ◽  
Acid Ester

Antioxidant and Antimicrobial Activity Evaluation of Polyhydroxycinnamic Acid Ester Derivatives.

ChemInform ◽  
2006 ◽  
Vol 37 (18) ◽  
Author(s):  
Somepalli Venkateswarlu ◽  
Marellapudi S. Ramachandra ◽  
Alluri V. Krishnaraju ◽  
Golakoti Trimurtulu ◽  
Gottumukkala V. Subbaraju
Keyword(s):  
Antimicrobial Activity ◽  
Acid Ester ◽  
Activity Evaluation ◽  
Antioxidant And Antimicrobial Activity

ChemInform Abstract: Preparation of Some Ursolic Acid Derivatives and Their Antimicrobial Activity.

ChemInform ◽  
1987 ◽  
Vol 18 (5) ◽  
Author(s):  
N. I. ZALETOVA ◽  
A. N. SHCHAVLINSKII ◽  
O. N. TOLKACHEV ◽  
S. A. VICHKANOVA ◽  
T. V. FATEEVA ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Ursolic Acid

Preparation of certain derivatives of ursolic acid and their antimicrobial activity

1986 ◽  
Vol 20 (5) ◽  
pp. 345-348 ◽  
Author(s):  
N. I. Zaletova ◽  
A. N. Shchavlinskii ◽  
O. N. Tolkachev ◽  
S. A. Vichkanova ◽  
T. V. Fateeva ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Ursolic Acid ◽  
Derivatives Of

Synthesis and antimicrobial activity of cationic aminoacetylene fatty acid ester surfactants

1987 ◽  
Vol 21 (7) ◽  
pp. 510-512
Author(s):  
M. S. Ergashev ◽  
A. G. Makhsumov ◽  
P. Il'khamdzhanov
Keyword(s):  
Antimicrobial Activity ◽  
Fatty Acid ◽  
Fatty Acid Ester ◽  
Acid Ester

Antimicrobial Activity of the Extract and Isolated Compounds from Baccharis dracunculifolia D. C. (Asteraceae)

2008 ◽  
Vol 63 (1-2) ◽  
pp. 40-46 ◽  
Author(s):  
Ademar A. da Silva Filho ◽  
João P. B. de Sousa ◽  
Sandra Soares ◽  
Niege A. J. C. Furtado ◽  
Márcio L. Andrade e Silva ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Ursolic Acid ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antibacterial Activities ◽  
Antimicrobial Activities ◽  
Phytochemical Study ◽  
Propolis Extract ◽  
Acid Lactone ◽  
First Time ◽  
Mic Value

Baccharis dracunculifolia D.C. (Asteraceae) is the most important plant source of the Brazilian green propolis. Since propolis is known for its antimicrobial activity, the aim of this work was to evaluate the antimicrobial activities of B. dracunculifolia and some of its isolated compounds. The results showed that the leaves extract of B. dracunculifolia (BdE) presents antifungal and antibacterial activities, especially against Candida krusei and Cryptococcus neoformans, for which the BdE showed IC50 values of 65 μg mL −1 and 40 μg mL−1, respectively. In comparison to the BdE, it was observed that the green propolis extract (GPE) showed better antimicrobial activity, displaying an IC50 value of 9 μg mL−1 against C. krusei. Also, a phytochemical study of the BdE was carried out, affording the isolation of ursolic acid (1), 2α-hydroxy-ursolic acid (2), isosakuranetin (3), aromadendrin-4′-methylether (4), baccharin (5), viscidone (6), hautriwaic acid lactone (7), and the clerodane diterpene 8. This is the first time that the presence of compounds 1, 2, and 8 in B. dracunculifolia has been reported. Among the isolated compounds, 1 and 2 showed antibacterial activity against methicillin- resistant Staphylococcus aureus, displaying IC50 values of 5 μg mL−1 and 3 μg mL−1, respectively. 3 was active against C. neoformans, showing an IC50 value of 15 μg mL−1 and a MIC value of 40 μg mL−1, while compounds 4→8 were inactive against all tested microorganisms. The results showed that the BdE, similar to the GPE, displays antimicrobial activity, which may be related to the effect of several compounds present in the crude extract.

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