Sequence-Specific Conjugates of Oligo(2′-O-methylribonucleotides) and Hairpin Oligocarboxamide Minor-Groove Binders: Design, Synthesis, and Binding Studies with Double-Stranded DNA

2005 ◽  
Vol 2 (7) ◽  
pp. 936-952 ◽  
Author(s):  
Darya S. Novopashina ◽  
Alexandre N. Sinyakov ◽  
Vladimir A. Ryabinin ◽  
Alya G. Venyaminova ◽  
Ludovic Halby ◽  
...  
Keyword(s):  
Minor Groove ◽  
Binding Studies ◽  
Design Synthesis ◽  
Minor Groove Binders ◽  
Double Stranded Dna ◽  
Groove Binders

scholarly journals Application of Cu(I)-catalyzed azide–alkyne cycloaddition for the design and synthesis of sequence specific probes targeting double-stranded DNA

2016 ◽  
Vol 12 ◽  
pp. 1348-1360 ◽  
Author(s):  
Svetlana V Vasilyeva ◽  
Vyacheslav V Filichev ◽  
Alexandre S Boutorine
Keyword(s):  
Minor Groove ◽  
Binding Parameters ◽  
Design And Synthesis ◽  
Minor Groove Binders ◽  
Double Stranded Dna ◽  
Triple Helices ◽  
Gel Shift ◽  
Groove Binders

Efficient protocols based on Cu(I)-catalyzed azide–alkyne cycloaddition were developed for the synthesis of conjugates of pyrrole–imidazole polyamide minor groove binders (MGB) with fluorophores and with triplex-forming oligonucleotides (TFOs). Diverse bifunctional linkers were synthesized and used for the insertion of terminal azides or alkynes into TFOs and MGBs. The formation of stable triple helices by TFO-MGB conjugates was evaluated by gel-shift experiments. The presence of MGB in these conjugates did not affect the binding parameters (affinity and triplex stability) of the parent TFOs.

scholarly journals Design, synthesis and antibacterial activity of minor groove binders: The role of non-cationic tail groups

2012 ◽  
Vol 56 ◽  
pp. 39-47 ◽  
Author(s):  
Abedawn I. Khalaf ◽  
Claire Bourdin ◽  
David Breen ◽  
Gavin Donoghue ◽  
Fraser J. Scott ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Minor Groove ◽  
Design Synthesis ◽  
Minor Groove Binders ◽  
Groove Binders

Binding Properties of the Conjugates of Oligo(2′-O-Methylribonucleotides) with Minor Groove Binders Targeted to Double Stranded DNA

ChemInform ◽  
2005 ◽  
Vol 36 (6) ◽  
Author(s):  
D. S. Novopashina ◽  
A. N. Sinyakov ◽  
V. A. Ryabinin ◽  
A. G. Venyaminova ◽  
L. Perrouault ◽  
...  
Keyword(s):  
Minor Groove ◽  
Binding Properties ◽  
Minor Groove Binders ◽  
Double Stranded Dna ◽  
Groove Binders

Head-to-headbis-Hairpin Polyamide Minor Groove Binders and Their Conjugates with Triplex-forming Oligonucleotides: Studies of Interaction with Target Double-stranded DNA

2007 ◽  
Vol 25 (1) ◽  
pp. 61-76 ◽  
Author(s):  
Ludovic Halby ◽  
Vladimir A. Ryabinin ◽  
Alexandre N. Sinyakov ◽  
Darya S. Novopashina ◽  
Alya G. Venyaminova ◽  
...  
Keyword(s):  
Minor Groove ◽  
Minor Groove Binders ◽  
Double Stranded Dna ◽  
Groove Binders

Design, Synthesis, and Biological Evaluation of Hybrid Molecules Containing α-Methylene-γ-butyrolactones and Polypyrrole Minor Groove Binders

2004 ◽  
Vol 47 (11) ◽  
pp. 2877-2886 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Maria del Carmen Nunez ◽  
Mojgan Aghazadeh Tabrizi ◽  
Erik De Clercq ◽  
Jan Balzarini ◽  
...  
Keyword(s):  
Minor Groove ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Minor Groove Binders ◽  
Hybrid Molecules ◽  
Groove Binders ◽  
Synthesis And Biological Evaluation

Binding Properties of the Conjugates of Oligo(2′‐O‐Methylribonucleotides) with Minor Groove Binders Targeted to Double Stranded DNA

2004 ◽  
Vol 23 (6-7) ◽  
pp. 1015-1022 ◽  
Author(s):  
D. S. Novopashina ◽  
A. N. Sinyakov ◽  
V. A. Ryabinin ◽  
A. G. Venyaminova ◽  
L. Perrouault ◽  
...  
Keyword(s):  
Minor Groove ◽  
Binding Properties ◽  
Minor Groove Binders ◽  
Double Stranded Dna ◽  
Groove Binders

scholarly journals Dissociation of minor groove binders from DNA: insights from metadynamics simulations

2008 ◽  
Vol 36 (18) ◽  
pp. 5910-5921 ◽  
Author(s):  
A. V. Vargiu ◽  
P. Ruggerone ◽  
A. Magistrato ◽  
P. Carloni
Keyword(s):  
Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders
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