Binding Properties of the Conjugates of Oligo(2′‐O‐Methylribonucleotides) with Minor Groove Binders Targeted to Double Stranded DNA

2004 ◽  
Vol 23 (6-7) ◽  
pp. 1015-1022 ◽  
Author(s):  
D. S. Novopashina ◽  
A. N. Sinyakov ◽  
V. A. Ryabinin ◽  
A. G. Venyaminova ◽  
L. Perrouault ◽  
...  
Keyword(s):  
Minor Groove ◽  
Binding Properties ◽  
Minor Groove Binders ◽  
Double Stranded Dna ◽  
Groove Binders

Binding Properties of the Conjugates of Oligo(2′-O-Methylribonucleotides) with Minor Groove Binders Targeted to Double Stranded DNA

ChemInform ◽  
2005 ◽  
Vol 36 (6) ◽  
Author(s):  
D. S. Novopashina ◽  
A. N. Sinyakov ◽  
V. A. Ryabinin ◽  
A. G. Venyaminova ◽  
L. Perrouault ◽  
...  
Keyword(s):  
Minor Groove ◽  
Binding Properties ◽  
Minor Groove Binders ◽  
Double Stranded Dna ◽  
Groove Binders

scholarly journals Application of Cu(I)-catalyzed azide–alkyne cycloaddition for the design and synthesis of sequence specific probes targeting double-stranded DNA

2016 ◽  
Vol 12 ◽  
pp. 1348-1360 ◽  
Author(s):  
Svetlana V Vasilyeva ◽  
Vyacheslav V Filichev ◽  
Alexandre S Boutorine
Keyword(s):  
Minor Groove ◽  
Binding Parameters ◽  
Design And Synthesis ◽  
Minor Groove Binders ◽  
Double Stranded Dna ◽  
Triple Helices ◽  
Gel Shift ◽  
Groove Binders

Efficient protocols based on Cu(I)-catalyzed azide–alkyne cycloaddition were developed for the synthesis of conjugates of pyrrole–imidazole polyamide minor groove binders (MGB) with fluorophores and with triplex-forming oligonucleotides (TFOs). Diverse bifunctional linkers were synthesized and used for the insertion of terminal azides or alkynes into TFOs and MGBs. The formation of stable triple helices by TFO-MGB conjugates was evaluated by gel-shift experiments. The presence of MGB in these conjugates did not affect the binding parameters (affinity and triplex stability) of the parent TFOs.

Sequence-Specific Conjugates of Oligo(2′-O-methylribonucleotides) and Hairpin Oligocarboxamide Minor-Groove Binders: Design, Synthesis, and Binding Studies with Double-Stranded DNA

2005 ◽  
Vol 2 (7) ◽  
pp. 936-952 ◽  
Author(s):  
Darya S. Novopashina ◽  
Alexandre N. Sinyakov ◽  
Vladimir A. Ryabinin ◽  
Alya G. Venyaminova ◽  
Ludovic Halby ◽  
...  
Keyword(s):  
Minor Groove ◽  
Binding Studies ◽  
Design Synthesis ◽  
Minor Groove Binders ◽  
Double Stranded Dna ◽  
Groove Binders

Head-to-headbis-Hairpin Polyamide Minor Groove Binders and Their Conjugates with Triplex-forming Oligonucleotides: Studies of Interaction with Target Double-stranded DNA

2007 ◽  
Vol 25 (1) ◽  
pp. 61-76 ◽  
Author(s):  
Ludovic Halby ◽  
Vladimir A. Ryabinin ◽  
Alexandre N. Sinyakov ◽  
Darya S. Novopashina ◽  
Alya G. Venyaminova ◽  
...  
Keyword(s):  
Minor Groove ◽  
Minor Groove Binders ◽  
Double Stranded Dna ◽  
Groove Binders

scholarly journals Dissociation of minor groove binders from DNA: insights from metadynamics simulations

2008 ◽  
Vol 36 (18) ◽  
pp. 5910-5921 ◽  
Author(s):  
A. V. Vargiu ◽  
P. Ruggerone ◽  
A. Magistrato ◽  
P. Carloni
Keyword(s):  
Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders

scholarly journals An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics

2017 ◽  
Vol 136 ◽  
pp. 561-572 ◽  
Author(s):  
Fraser J. Scott ◽  
Ryan J.O. Nichol ◽  
Abedawn I. Khalaf ◽  
Federica Giordani ◽  
Kirsten Gillingwater ◽  
...  
Keyword(s):  
Minor Groove ◽  
Minor Groove Binders ◽  
Anti Fungal ◽  
Groove Binders

Conjugates between minor groove binders and Zn(II)-tach complexes: Synthesis, characterization, and interaction with plasmid DNA

Tetrahedron ◽  
2017 ◽  
Vol 73 (21) ◽  
pp. 3014-3024 ◽  
Author(s):  
Claudia Sissi ◽  
Luca Dovigo ◽  
Maria Laura Greco ◽  
Antonella Ciancetta ◽  
Stefano Moro ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Minor Groove ◽  
Minor Groove Binders ◽  
Groove Binders
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