scholarly journals Novel nanofibrous membrane‐supporting stem cell sheets for plasmid delivery and cell activation to accelerate wound healing

2021 ◽  
Author(s):  
Yanxia Zhu ◽  
Yuqi Liao ◽  
Yuanyuan Zhang ◽  
Mehdihasan I. Shekh ◽  
Jianhao Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Cell Activation ◽  
Nanofibrous Membrane ◽  
Cell Sheets ◽  
Accelerate Wound Healing ◽  
Plasmid Delivery

Injectable silk nanofiber hydrogels as stem cell carriers to accelerate wound healing

2021 ◽  
Vol 9 (37) ◽  
pp. 7771-7781
Author(s):  
Jiadai Li ◽  
Zhaozhao Ding ◽  
Xin Zheng ◽  
Guozhong Lu ◽  
Qiang Lu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Stem Cell ◽  
Hair Follicle ◽  
Cell Behaviors ◽  
Accelerate Wound Healing ◽  
Cell Carriers

Injectable silk nanofiber hdyrogels were used to load stem cells and regulate cell behaviors effectively. The stem cell–laden silk hydrogels accelerated wound healing with higher quality and hair follicle regeneration.

Effective stacking and transplantation of stem cell sheets using exogenous ROS-producing film for accelerated wound healing

2019 ◽  
Vol 95 ◽  
pp. 418-426 ◽  
Author(s):  
Min-Ah Koo ◽  
Seung Hee Hong ◽  
Mi Hee Lee ◽  
Byeong-Ju Kwon ◽  
Gyeung Mi Seon ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Cell Sheets

scholarly journals Protein-Engineered Large Area Adipose-derived Stem Cell Sheets for Wound Healing

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Jongbeom Na ◽  
Seung Yong Song ◽  
Jae Dong Kim ◽  
Minsu Han ◽  
June Seok Heo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Large Area ◽  
Cell Sheets ◽  
Adipose Derived Stem Cell

Healing gone wrong: convergence of hemostatic pathways and liver fibrosis?

2020 ◽  
Vol 134 (16) ◽  
pp. 2189-2201
Author(s):  
Jessica P.E. Davis ◽  
Stephen H. Caldwell
Keyword(s):  
Wound Healing ◽  
Liver Disease ◽  
Hepatic Fibrosis ◽  
Cell Activation ◽  
Stellate Cell ◽  
Factor Xa ◽  
Clinical Trial Data ◽  
Chronic Liver ◽  
Healing Response ◽  
Wound Healing Response

Abstract Fibrosis results from a disordered wound healing response within the liver with activated hepatic stellate cells laying down dense, collagen-rich extracellular matrix that eventually restricts liver hepatic synthetic function and causes increased sinusoidal resistance. The end result of progressive fibrosis, cirrhosis, is associated with significant morbidity and mortality as well as tremendous economic burden. Fibrosis can be conceptualized as an aberrant wound healing response analogous to a chronic ankle sprain that is driven by chronic liver injury commonly over decades. Two unique aspects of hepatic fibrosis – the chronic nature of insult required and the liver’s unique ability to regenerate – give an opportunity for pharmacologic intervention to stop or slow the pace of fibrosis in patients early in the course of their liver disease. Two potential biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence of hemostatic changes and hepatic fibrosis in chronic liver disease and present current preclinical and clinical data exploring the relationship between the two. We will also present clinical trial data that underscores the potential use of anticoagulant therapy as an antifibrotic factor in liver disease.

Sign in / Sign up

Export Citation Format

Share Document