Rapid identification of cimetropium bromide metabolites using constant neutral loss tandem mass spectrometry

1992 ◽  
Vol 21 (3) ◽  
pp. 165-175 ◽  
Author(s):  
S. Naylor ◽  
M. Kajbaf ◽  
J. H. Lamb ◽  
M. Jahanshahi ◽  
J. W. Gorrod
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Neutral Loss ◽  
Rapid Identification ◽  
Tandem Mass ◽  
Constant Neutral Loss ◽  
Cimetropium Bromide

scholarly journals A fast screening method for tricyclic antidepressants and their urinary metabolites by FAB-tandem mass spectrometry

1997 ◽  
Vol 13 (3) ◽  
pp. 213-226 ◽  
Author(s):  
M. Schäfer ◽  
H. Budzikiewicz ◽  
H. Brzezinka ◽  
M. Schifferdecker
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Urine Sample ◽  
Tricyclic Antidepressants ◽  
Neutral Loss ◽  
Screening Method ◽  
Urinary Metabolites ◽  
Molecular Ions ◽  
Tandem Mass ◽  
Constant Neutral Loss

A screening method for tricyclic antidepressants (TCA) and their urinary metabolites by FAB tandem mass spectrometry (FAB MS/MS) is presented. The collision induced dissociation (CID) behavior of pure dibenzocycloheptadienes (amitriptyline1, nortriptyline2), dibenzoxepines (doxepine3, dosulepine4), dibenzazepines (imipramine5, desipramine6, trimipramine7) and the iminostilbene derivative opipramol8is described and used for the specific determination of these tricyclics by MS/MS.For the screening procedure a methanolic extract of the urine sample is passed through a XAD-2 column and the eluate is examined without further purification after evaporation of the solvent. Identification of the TCA is achieved by constant neutral loss (CNL) scans for 173 u, 195 u and 193 u and subsequent daughter ion spectra of the molecular ions [M+H]+. Glucuronide conjugate metabolites of the tricyclic antidepressants1,2,3,6,8could be identified by CNL-scans (176 u) and the assignments were confirmed by daughter ion mass spectra. A urine sample of a fatal1,2,8overdose and samples of three patients under therapeutic dosage with1,3or6are presented as examples for application.

Analysis of Protein Phosphorylation by a Combination of Elastase Digestion and Neutral Loss Tandem Mass Spectrometry

2001 ◽  
Vol 73 (2) ◽  
pp. 170-176 ◽  
Author(s):  
Andreas Schlosser ◽  
Ruediger Pipkorn ◽  
Dirk Bossemeyer ◽  
Wolf D. Lehmann
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Protein Phosphorylation ◽  
Neutral Loss ◽  
Tandem Mass

scholarly journals Rapid identification of disaccharides by tandem mass spectrometry

2013 ◽  
Vol 48 (12) ◽  
pp. 1276-1280 ◽  
Author(s):  
Ákos Kuki ◽  
Katalin E. Szabó ◽  
Lajos Nagy ◽  
Miklós Zsuga ◽  
Sándor Kéki
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Rapid Identification ◽  
Tandem Mass
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