Pharmacokinetic and brain distribution study of an anti‐glioblastoma agent in mice by HPLC‐MS/MS

2022 ◽  
Author(s):  
Yaxin Li ◽  
Raina Dano ◽  
Cathy Li ◽  
Wenjing Zhang ◽  
Justin D. Lathia ◽  
...  
Keyword(s):  
Brain Distribution ◽  
Distribution Study

UPLC-MS/MS method for determination of schisandrin in rat plasma and brain microdialysates: application to a comparative pharmacokinetic and brain distribution study in normal and Alzheimer’s disease rats

2017 ◽  
Vol 9 (32) ◽  
pp. 4740-4746 ◽  
Author(s):  
BinBin Wei ◽  
Mingyan Liu ◽  
Zaixing Chen ◽  
Minjie Wei
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Plasma ◽  
Brain Distribution ◽  
Comparative Pharmacokinetic ◽  
Distribution Study

An efficient UPLC-MS/MS method for determining schisandrin in rat plasma and brain microdialysates has been developed and validated.

Transnasomucosal mucoadhesive microemulsion of zaltoprofen: A comparative brain distribution study

2017 ◽  
Vol 39 ◽  
pp. 237-246
Author(s):  
Surjyanarayan Mandal ◽  
Snigdha Das Mandal ◽  
Krishna Chuttani ◽  
Abhay Dharamsi ◽  
Bharat bhushan Subudhi
Keyword(s):  
Brain Distribution ◽  
Distribution Study

scholarly journals Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3210
Author(s):  
Talib Hussain ◽  
Sathishbabu Paranthaman ◽  
Syed Mohd Danish Rizvi ◽  
Afrasim Moin ◽  
Devegowda Vishakante Gowda ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
C6 Glioma Cells ◽  
Brain Distribution ◽  
Distribution Study ◽  
Therapeutic Modalities ◽  
The Central Nervous System ◽  
Distribution Studies

Gliomas are one of the prominent cancers of the central nervous system with limited therapeutic modalities. The present investigation evaluated the synergistic effect of paclitaxel (PAX) and resveratrol (RESV)-loaded Soluplus polymeric nanoparticles (PNPs) against glioma cell lines along with in vivo pharmacokinetics and brain distribution study. PAX-RESV-loaded PNPs were prepared by the thin film hydration technique and optimized for different dependent and independent variables by using DoE (Design-Expert) software. The in vitro physiochemical characterization of prepared PAX-RESV-loaded PNPs exhibited appropriate particle size, PDI and % encapsulation efficiency. Cytotoxicity assay revealed that PTX-RESV loaded PNPs had a synergistic antitumor efficacy against C6 glioma cells compared with single and combined pure drugs. Finally, the pharmacokinetic and brain distribution studies in mice demonstrated that the PNPs significantly enhanced the bioavailability of PTX-RESV PNPs than pure PAX and RESV. Thus, the study concluded that PAX-RESV PNPs combination could significantly enhance anti-glioma activity, and this could be developed into a potential glioma treatment strategy.

Brain Distribution Study of Imperatorin in Rats after Oral Administration Assessed by HPLC

2011 ◽  
Vol 74 (3-4) ◽  
pp. 259-265 ◽  
Author(s):  
Xiaokai Zhang ◽  
Yanhua Xie ◽  
Wei Cao ◽  
Qian Yang ◽  
Shan Miao ◽  
...  
Keyword(s):  
Oral Administration ◽  
Brain Distribution ◽  
Distribution Study

Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study

Nanoscale ◽  
2010 ◽  
Vol 2 (12) ◽  
pp. 2826 ◽  
Author(s):  
Fernanda Sousa ◽  
Subhra Mandal ◽  
Chiara Garrovo ◽  
Alberto Astolfo ◽  
Alois Bonifacio ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Brain Distribution ◽  
Distribution Study ◽  
Functionalized Gold Nanoparticles

Distribution of Aedes aegypti and Aedes albopictus in different eco zones of Thiruvananthapuram city with special reference to dengue viremia in humans

ENTOMON ◽  
2018 ◽  
Vol 43 (4) ◽  
pp. 223-230
Author(s):  
S. Sunil Kumar ◽  
D.A. Evans ◽  
K. Muthulakshmi ◽  
T. DilipKumar ◽  
R. Heera Pillai ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Aedes Albopictus ◽  
Dengue Shock Syndrome ◽  
Single Step ◽  
Equal Distribution ◽  
Distribution Study ◽  
Urban Zone ◽  
High Prevalence ◽  
Vector Management ◽  
Efficient Vector

Mosquito index study of three ecologically different ecozones of the Thiruvananthapuram district, Kerala showed sharp difference on the proportionate distribution of Aedes aegypti and Aedes albopictus. Human dengue viremia (HDV) was very high in those ecozones where A.aegypti density was high and HDV was low where A.albopictus was high. In a coastal zone of Thiruvananthapuram city, A. aegypti was the most abundant vector and in a hilly, arid suburban zone, A.albopictus was the abundant vector. In the urban zone both species of mosquitoes showed equal distribution. Study on the circulating serotypes in the serum of HDV by Single step single tube Multiplex PCR showed all the four serotypes viz DENV1, DENV2, DENV3 and DENV4 in patients of Thiruvananthapuram city, which indicated the possibility of Dengue Shock Syndrome, unless there is efficient vector management. Among the four dengue serotypes, Type 1 was the most abundant virus. Abundance of microhabitats in Thiruvananthapuram city, which support A. aegypti may be the reason for high prevalence of dengue fever in the urban zone.

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