Functionalized gold nanoparticles: a detailed in vivo multimodal microscopic brain distribution study

Nanoscale ◽  
2010 ◽  
Vol 2 (12) ◽  
pp. 2826 ◽  
Author(s):  
Fernanda Sousa ◽  
Subhra Mandal ◽  
Chiara Garrovo ◽  
Alberto Astolfo ◽  
Alois Bonifacio ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Brain Distribution ◽  
Distribution Study ◽  
Functionalized Gold Nanoparticles

scholarly journals Anti-osteoclastogenic effect of epigallocatechin gallate-functionalized gold nanoparticles in vitro and in vivo

2019 ◽  
Vol Volume 14 ◽  
pp. 5017-5032 ◽  
Author(s):  
Shenting Zhu ◽  
Lingxin Zhu ◽  
Jingjing Yu ◽  
Yanqing Wang ◽  
Bin Peng
Keyword(s):  
Gold Nanoparticles ◽  
Epigallocatechin Gallate ◽  
Functionalized Gold Nanoparticles

Lanthanide (Gd3+ and Yb3+) functionalized gold nanoparticles for in vivo imaging and therapy

Biomaterials ◽  
2016 ◽  
Vol 108 ◽  
pp. 35-43 ◽  
Author(s):  
Xiaoqian Ge ◽  
Zheng-Mei Song ◽  
Lining Sun ◽  
Yi-Fan Yang ◽  
Liyi Shi ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
In Vivo Imaging ◽  
Functionalized Gold Nanoparticles

scholarly journals Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3210
Author(s):  
Talib Hussain ◽  
Sathishbabu Paranthaman ◽  
Syed Mohd Danish Rizvi ◽  
Afrasim Moin ◽  
Devegowda Vishakante Gowda ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
C6 Glioma Cells ◽  
Brain Distribution ◽  
Distribution Study ◽  
Therapeutic Modalities ◽  
The Central Nervous System ◽  
Distribution Studies

Gliomas are one of the prominent cancers of the central nervous system with limited therapeutic modalities. The present investigation evaluated the synergistic effect of paclitaxel (PAX) and resveratrol (RESV)-loaded Soluplus polymeric nanoparticles (PNPs) against glioma cell lines along with in vivo pharmacokinetics and brain distribution study. PAX-RESV-loaded PNPs were prepared by the thin film hydration technique and optimized for different dependent and independent variables by using DoE (Design-Expert) software. The in vitro physiochemical characterization of prepared PAX-RESV-loaded PNPs exhibited appropriate particle size, PDI and % encapsulation efficiency. Cytotoxicity assay revealed that PTX-RESV loaded PNPs had a synergistic antitumor efficacy against C6 glioma cells compared with single and combined pure drugs. Finally, the pharmacokinetic and brain distribution studies in mice demonstrated that the PNPs significantly enhanced the bioavailability of PTX-RESV PNPs than pure PAX and RESV. Thus, the study concluded that PAX-RESV PNPs combination could significantly enhance anti-glioma activity, and this could be developed into a potential glioma treatment strategy.

scholarly journals Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy

Theranostics ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. 3168-3178 ◽  
Author(s):  
Huaxin Tan ◽  
Yazhou Huang ◽  
Jianghong Xu ◽  
Bo Chen ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Tumor Targeting ◽  
Functionalized Gold Nanoparticles ◽  
Spider Toxin

Spider toxin peptide lycosin-i functionalized gold nanoparticles for in vivo tumor targeting and therapy

Toxicon ◽  
2019 ◽  
Vol 158 ◽  
pp. S2
Author(s):  
Huaxin Tan ◽  
Yazhou Huang ◽  
Jianghong Xu ◽  
Bo Chen ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Tumor Targeting ◽  
Functionalized Gold Nanoparticles ◽  
Spider Toxin

scholarly journals An enzyme-responsive metal-enhanced near-infrared fluorescence sensor based on functionalized gold nanoparticles

2015 ◽  
Vol 6 (8) ◽  
pp. 4934-4939 ◽  
Author(s):  
Zhanghua Zeng ◽  
Shin Mizukami ◽  
Katsumasa Fujita ◽  
Kazuya Kikuchi
Keyword(s):  
Gold Nanoparticles ◽  
Diagnostic Imaging ◽  
Surface Functionalization ◽  
Near Infrared ◽  
Fluorescence Sensor ◽  
Near Infrared Fluorescence ◽  
Functionalized Gold Nanoparticles ◽  
Enzyme Detection ◽  
Early Diagnostic

An enzyme-responsive NIR nanosystem based on MEF was fabricated by surface functionalization of gold nanoparticles. Sensors based on this strategy are promising for enzyme detection in early diagnostic imaging and in vivo applications.

In vivotargeting of DNA vaccines to dendritic cells using functionalized gold nanoparticles

2019 ◽  
Vol 7 (3) ◽  
pp. 773-788 ◽  
Author(s):  
Suresh Kumar Gulla ◽  
Bonda Rama Rao ◽  
Gopikrishna Moku ◽  
Sudhakar Jinka ◽  
Narendra Varma Nimmu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Dendritic Cells ◽  
Dna Vaccines ◽  
Functionalized Gold Nanoparticles ◽  
Thiol Ligand

Gold nanoparticles functionalized with a thiol ligand containing both mannose mimicking shikimoyl- and transfection enhancing guanidinyl-functionalities forin vivodelivery of DNA vaccines to dendritic cells.

Therapeutic nanomedicine based on dual-intelligent functionalized gold nanoparticles for cancer imaging and therapy in vivo

Biomaterials ◽  
2013 ◽  
Vol 34 (34) ◽  
pp. 8798-8807 ◽  
Author(s):  
Wei-Hai Chen ◽  
Xiao-Ding Xu ◽  
Hui-Zhen Jia ◽  
Qi Lei ◽  
Guo-Feng Luo ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Imaging ◽  
Functionalized Gold Nanoparticles

scholarly journals Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor specificity

2010 ◽  
Vol 107 (19) ◽  
pp. 8760-8765 ◽  
Author(s):  
N. Chanda ◽  
V. Kattumuri ◽  
R. Shukla ◽  
A. Zambre ◽  
K. Katti ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Receptor Specificity ◽  
Functionalized Gold Nanoparticles
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