Development of a new UPLC-MSMS method for the determination of temozolomide in mice: application to plasma pharmacokinetics and brain distribution study

2013 ◽  
Vol 27 (7) ◽  
pp. 889-893 ◽  
Author(s):  
Lauriane Goldwirt ◽  
Noel Zahr ◽  
Robert Farinotti ◽  
Christine Fernandez
Keyword(s):  
Brain Distribution ◽  
Distribution Study ◽  
Plasma Pharmacokinetics

UPLC-MS/MS method for determination of schisandrin in rat plasma and brain microdialysates: application to a comparative pharmacokinetic and brain distribution study in normal and Alzheimer’s disease rats

2017 ◽  
Vol 9 (32) ◽  
pp. 4740-4746 ◽  
Author(s):  
BinBin Wei ◽  
Mingyan Liu ◽  
Zaixing Chen ◽  
Minjie Wei
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Plasma ◽  
Brain Distribution ◽  
Comparative Pharmacokinetic ◽  
Distribution Study

An efficient UPLC-MS/MS method for determining schisandrin in rat plasma and brain microdialysates has been developed and validated.

Determination of brusatol in plasma and tissues by LC–MS method and its application to a pharmacokinetic and distribution study in mice

2017 ◽  
Vol 1053 ◽  
pp. 20-26 ◽  
Author(s):  
Nan Guo ◽  
Xiaoran Zhang ◽  
Fanlong Bu ◽  
Lei Wang ◽  
Zhanqi Cao ◽  
...  
Keyword(s):  
Distribution Study

Pharmacokinetic and brain distribution study of an anti‐glioblastoma agent in mice by HPLC‐MS/MS

2022 ◽  
Author(s):  
Yaxin Li ◽  
Raina Dano ◽  
Cathy Li ◽  
Wenjing Zhang ◽  
Justin D. Lathia ◽  
...  
Keyword(s):  
Brain Distribution ◽  
Distribution Study

Determination of bosutinib in mice plasma and tissue by UPLC-MS/MS and its application to the pharmacokinetic and tissue distribution study

2015 ◽  
Vol 7 (21) ◽  
pp. 9184-9189 ◽  
Author(s):  
Linxia Wang ◽  
Luming Tang ◽  
Yi Zheng ◽  
Guoquan Pan ◽  
Wei Zhu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Internal Standard ◽  
Ultra Performance Liquid Chromatography ◽  
Tandem Mass ◽  
Distribution Study ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Tissue Distribution Study

A sensitive and rapid ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed to determine bosutinib in mice plasma and tissue using diazepam as the internal standard (IS).

Transnasomucosal mucoadhesive microemulsion of zaltoprofen: A comparative brain distribution study

2017 ◽  
Vol 39 ◽  
pp. 237-246
Author(s):  
Surjyanarayan Mandal ◽  
Snigdha Das Mandal ◽  
Krishna Chuttani ◽  
Abhay Dharamsi ◽  
Bharat bhushan Subudhi
Keyword(s):  
Brain Distribution ◽  
Distribution Study

scholarly journals Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MS/MS: Application to Comparative Pharmacokinetic and Brain Distribution Studies

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Bo Li ◽  
Min Lu ◽  
Lei Jin ◽  
Maoen Zheng ◽  
Peilu Sun ◽  
...  
Keyword(s):  
High Performance ◽  
Brain Homogenate ◽  
Gradient Elution ◽  
Rat Plasma ◽  
Brain Distribution ◽  
Single Oral Administration ◽  
Mass Spectrometric Detector ◽  
Distribution Studies ◽  
Lower Limits

Brigatinib and brigatinib-analog are potent and selective ALK inhibitors with the similar structure. A simple and sensitive high-performance liquid chromatography with tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of brigatinib and brigatinib-analog in rat plasma and brain homogenate was developed and validated. Chromatographic separation was carried out on an ODS column with acetonitrile and 0.1% formic acid in water as the mobile phase with gradient elution at a flow rate of 0.5 mL/min. Detections were performed using a TSQ Quantum Ultra mass spectrometric detector with electrospray ionization (ESI) interface, which was operated in the positive ion mode. A simple protein precipitation preparation process was used. The lower limits of quantification (LLOQs) were 1.0 ng/mL and 0.5 ng/mL for analytes in rat plasma and brain homogenate, respectively. The intrabatch and interbatch precision and accuracy of brigatinib and brigatinib-analog were well within the acceptable limits of variation. The simple and sensitive LC-MS/MS method was successfully applied to the pharmacokinetic and brain distribution studies following a single oral administration of brigatinib and brigatinib-analog to rats. The above studies would lay a good foundation for the further applications of brigatinib and brigatinib-analog.

Quantitative determination of periplocymarin in rat plasma and tissue by LC-MS/MS: application to pharmacokinetic and tissue distribution study

2016 ◽  
Vol 30 (8) ◽  
pp. 1195-1201 ◽  
Author(s):  
Kaijing Yan ◽  
Xiangyang Wang ◽  
Yumeng Jia ◽  
Yang Chu ◽  
Xiufeng Guan ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Tissue Distribution ◽  
Rat Plasma ◽  
Distribution Study ◽  
Tissue Distribution Study
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