Behavior of peptides and computer-assisted optimization of peptides separations in a normal-phase thin-layer chromatography system with and without the addition of ionic liquid in the eluent

2005 ◽  
Vol 19 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Tomasz B?czek ◽  
Micha? P. Marsza?? ◽  
Roman Kaliszan ◽  
?ukasz Walijewski ◽  
Wanda Makowiecka ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Normal Phase ◽  
Computer Assisted ◽  
Layer Chromatography ◽  
Thin Layer Chromatography System

scholarly journals Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites

2009 ◽  
Vol 74 (6) ◽  
pp. 677-688 ◽  
Author(s):  
Jadranka Odovic ◽  
Mirjana Aleksic ◽  
Biljana Stojimirovic ◽  
Dusanka Milojkovic-Opsenica ◽  
Zivoslav Tesic
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Ace Inhibitors ◽  
Reversed Phase ◽  
Normal Phase ◽  
Converting Enzyme ◽  
Reversed Phase Chromatography ◽  
Aqueous Solvent ◽  
Layer Chromatography

The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters 0M R and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography.

SYNTHESIS OF THE 2,4-DI-O-METHYL TETROSES

1964 ◽  
Vol 42 (3) ◽  
pp. 614-619 ◽  
Author(s):  
G. G. S. Dutton ◽  
K. N. Slessor
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Silica Gel ◽  
Periodate Oxidation ◽  
Free Sugars ◽  
Layer Chromatography ◽  
Thin Layer Chromatography System

The four isomeric 2,4-di-O-methyl tetroses were prepared by periodate oxidation of known methylated sugars. 2,4-Di-O-methyl-D- and L-erythroses were prepared from 4,6-di-O-methyl-D-glucose and 3,5-di-O-methyl-L-arabinose respectively. 2,4-Di-O-methyl-D- and L-threoses were prepared from 3,5-di-O-methyl-D-xylose and 1,4,6-tri-O-methyl-L-sorbose.The tetroses were characterized by their crystalline 2,4-dinitrophenylhydrazones. The RF and RG values of the free sugars were recorded in a variety of solvents including a silica gel thin-layer chromatography system.

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