Determination of lipoic acid in rat plasma by LC-MS/MS with electrospray ionization: Assay development, validation and application to a pharamcokinetic study

2004 ◽  
Vol 18 (9) ◽  
pp. 681-686 ◽  
Author(s):  
Ravi Kumar Trivedi ◽  
Raja Reddy Kallem ◽  
Rao N. V. S. Mamidi ◽  
Ramesh Mullangi ◽  
Nuggehally R. Srinivas
Keyword(s):  
Electrospray Ionization ◽  
Lipoic Acid ◽  
Rat Plasma ◽  
Assay Development

Determination of newly synthesized lipoic acid–fasudil dimer in rat plasma by LC-MS/MS and its application to pharmacokinetics study

2014 ◽  
Vol 6 (21) ◽  
pp. 8675-8681 ◽  
Author(s):  
Waner Hou ◽  
Guanghui Liu ◽  
Xiuman Sun ◽  
Zhiyong Xie ◽  
Rongbiao Pi ◽  
...  
Keyword(s):  
Electrospray Ionization ◽  
Lipoic Acid ◽  
Internal Standard ◽  
Rat Plasma ◽  
Pharmacokinetics Study

The aim of the present work was to develop and validate an LC-MS/MS method with electrospray ionization (ESI) for the quantification of lipoic acid–fasudil dimer (L–F 001), a novel multi-functional neuroprotective drug in rat plasma, using tetrahydropalmatine as an internal standard.

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