Highly sensitive LC-MS/MS-ESI method for simultaneous quantitation of albendazole and ricobendazole in rat plasma and its application to a rat pharmacokinetic study

2011 ◽  
Vol 26 (2) ◽  
pp. 247-255 ◽  
Author(s):  
Kuldeep Sharma ◽  
Murugesh Kandaswamy ◽  
Chandan Mithra ◽  
Ashok Kumar Meena ◽  
Sanjeev Giri ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Highly Sensitive

HIGHLY SENSITIVE LC-MS/MS METHOD FOR THE DETERMINATION OF CLOZAPINE IN RAT PLASMA: APPLICATION TO A PRECLINICAL PHARMACOKINETIC STUDY

2012 ◽  
Vol 35 (20) ◽  
pp. 2873-2883 ◽  
Author(s):  
Sandra Elisa Haas ◽  
Liberato Brum ◽  
Cristiane de Andrade ◽  
Francine Johansson Azeredo ◽  
Maiara Pigatto ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Highly Sensitive

Simultaneous Determination of Three Alkaloids in Wutou Decoction in Rat Plasma Via the UPLC–MS/MS Method and its Application in Pharmacokinetic Study

2020 ◽  
Vol 16 (5) ◽  
pp. 558-563
Author(s):  
WU Jian ◽  
JI Yu-bin ◽  
Liu Ying-jie ◽  
XU Ying ◽  
Zheng Wei ◽  
...  
Keyword(s):  
Electrospray Ionization ◽  
Pharmacokinetic Study ◽  
Multiple Reaction Monitoring ◽  
Ultra Performance Liquid Chromatography ◽  
Rat Plasma ◽  
Pharmacokinetic Parameters ◽  
Intragastric Administration ◽  
Highly Sensitive ◽  
Pharmacokinetic Properties

Introduction: Wutou decoction has been wildly applied for the treatment of RA in China for several thousand years. Methods: This study aims to develop a highly sensitive and specific ultra performance liquid chromatography coupled with tandem mass spectrometry and electrospray ionization (UPLC-ESI-MS/MS) method to explore the pharmacokinetic properties of three representative bioactive alkaloids after intragastric administration of Wutou decoction in rats. Chromatographic separation was performed on a C18 column under the Multiple Reaction Monitoring (MRM) in the positive electrospray ionization (ESI) mode. The pharmacokinetic parameters were evaluated by software DAS 3. 0. Results: The validation of the method was achieved in accordance with the FDA guidelines. The results of pharmacokinetic study showed that the in vivo concentrations of benzoylmesaconine and benzoylhypaconine were significantly higher than benzoylaconine. Our PK results showed that these three compounds were quickly absorbed after the administration of Wutou decoction, and Tmax ranged from 30 min to 45 min. Conclusion: The results of pharmacokinetic study showed that the in vivo concentrations of benzoylmesaconine and benzoylhypaconine were significantly higher than benzoylaconine. There were also similar pharmacokinetic behaviors observed among BAC, BHA, and BMA after oral administration of WTD.

Development and validation of a highly sensitive LC-MS/MS-ESI method for the determination of nobiletin in rat plasma: application to a pharmacokinetic study

2012 ◽  
Vol 26 (12) ◽  
pp. 1464-1471 ◽  
Author(s):  
Avinash Kumar ◽  
V. C. Devaraj ◽  
Kalpesh C. Giri ◽  
Sanjeev Giri ◽  
Sriram Rajagopal ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Highly Sensitive ◽  
Development And Validation

A highly sensitive LC-MS/MS method for the determination of S-citalopram in rat plasma: application to a pharmacokinetic study in rats

2010 ◽  
Vol 24 (10) ◽  
pp. 1052-1058 ◽  
Author(s):  
P. S. Suresh ◽  
Sanjeev Giri ◽  
Raghib Husain ◽  
Ramesh Mullangi
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Highly Sensitive

Development and validation of a highly sensitive LC–ESI-MS/MS method for the determination of Orteronel® (TAK-700) in rat plasma: application to a pharmacokinetic study

Bioanalysis ◽  
2012 ◽  
Vol 4 (12) ◽  
pp. 1471-1480 ◽  
Author(s):  
Sandip Gurav ◽  
Anitha Police ◽  
Mohd Zainuddin ◽  
Junaid Hassan Farooqui ◽  
Krishna Reddy G ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Esi Ms ◽  
Highly Sensitive ◽  
Development And Validation

A highly sensitive LC-MS/MS method for the determination of S-raclopride in rat plasma: application to a pharmacokinetic study in rats

2010 ◽  
Vol 25 (8) ◽  
pp. 930-937 ◽  
Author(s):  
Suresh P. S Ravindra Ramachandra Punde ◽  
Manish Gupta ◽  
Abhishek Dixit ◽  
Sanjeev Giri ◽  
Sriram Rajagopal ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Highly Sensitive

Quantification of annonacin in Rat plasma: Application to pharmacokinetic study

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
N Bonneau ◽  
I Schmitz Afonso ◽  
D Touboul ◽  
A Brunelle ◽  
P Champy
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma
Sign in / Sign up

Export Citation Format

Share Document