scholarly journals Prognostic significance of Ki-67 antigen and p53 protein expression in pancreatic duct carcinoma: a study of the monoclonal antibodies MIB-1 and DO-7 in formalin-fixed paraffin-embedded tumour material

1997 ◽  
Vol 76 (1) ◽  
pp. 54-59 ◽  
Author(s):  
S Linder ◽  
C Parrado ◽  
UG Falkmer ◽  
M Blåsjö ◽  
P Sundelin ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
P53 Protein ◽  
Prognostic Significance ◽  
Ki 67 ◽  
Duct Carcinoma ◽  
P53 Protein Expression ◽  
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Mib 1

Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections

1992 ◽  
Vol 168 (4) ◽  
pp. 357-363 ◽  
Author(s):  
Giorgio Cattoretti ◽  
Michael H. G. Becker ◽  
Göran Key ◽  
Michael Duchrow ◽  
Carsten Schlüuter ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Paraffin Sections ◽  
Proliferating Cells ◽  
Ki 67 ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed ◽  
Mib 1

Expression of proliferation genes in formalin-fixed paraffin-embedded (FFPE) tissue from breast carcinomas. Feasibility and relevance for a routine histopathology laboratory

2016 ◽  
Vol 70 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Carla Thomas ◽  
Cleo Robinson ◽  
Ben Dessauvagie ◽  
Benjamin Wood ◽  
Greg Sterrett ◽  
...  
Keyword(s):  
Gene Expression ◽  
Breast Carcinoma ◽  
Expression Profiling ◽  
Proliferative Activity ◽  
Breast Cancers ◽  
Breast Carcinomas ◽  
Ki 67 ◽  
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Formalin Fixed

AimBreast carcinoma proliferative activity, histological grade and commercial molecular tests are all important in prognostication and treatment. There is a particular need for improved, standardised techniques for subclassification of grade 2 breast cancers into low-risk and high-risk prognostic groups. In this study we investigated whether gene expression profiling of five proliferation genes was feasible using breast cancer tissue in a clinical setting and whether these profiles could enhance pathological assessment.MethodsExpression of five proliferation gene mRNAs; Ki-67, STK 15, CCNB1, CCND1 and MYBL2, was quantified in 27 breast carcinomas and compared with Ki-67 proliferation index (PI) and Nottingham mitotic score.ResultsExpression of Ki-67, STK15 and MYBL2 mRNA showed moderate Spearman's correlation with Ki-67 PI (p<0.01), but CCND1 and CCNB1 showed weak, non-significant correlation. Individual gene expression did not associate with mitotic score but combined mRNA expression correlated with both Ki-67 PI (p=0.018) and mitotic score (p=0.03; 0.007).ConclusionsThis study confirms mRNA analysis in breast carcinoma formalin-fixed, paraffin-embedded samples is feasible and suggests gene expression profiling, using a small set of five proliferation genes, has potential in aiding histological grading or assessment of proliferative activity of breast cancers. To fully evaluate the clinical applicability of this approach, a larger cohort study with long-term follow-up data is required.

Identification of porcine macrophages with monoclonal antibodies in formalin-fixed, paraffin-embedded tissues

2003 ◽  
Vol 94 (1-2) ◽  
pp. 77-81 ◽  
Author(s):  
Nieves Domenech ◽  
M.Pilar Rodrı&#x;guez-Carreño ◽  
Purificación Filgueira ◽  
Belén Alvarez ◽  
Sonia Chamorro ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Formalin Fixed
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