Interrelations between serum gastrin levels, gastric emptying and acid output before and after proximal gastric vagotomy and truncal vagotomy and antrectomy

1979 ◽  
Vol 66 (3) ◽  
pp. 149-151 ◽  
Author(s):  
I. A. Donovan ◽  
Caroline Owens ◽  
B. G. Clendinnen ◽  
D. W. Griffin ◽  
L. K. Harding ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Serum Gastrin ◽  
Acid Output ◽  
Truncal Vagotomy ◽  
Proximal Gastric Vagotomy ◽  
Before And After

The Relation between Functioning Parietal Cell and Gastrin Cell Masses in Two Groups of Duodenal Ulcer Patients

1976 ◽  
Vol 50 (5) ◽  
pp. 375-383 ◽  
Author(s):  
D. J. Byrnes ◽  
Shiu Kum Lam ◽  
W. Sircus
Keyword(s):  
Duodenal Ulcer ◽  
Parietal Cell ◽  
Serum Gastrin ◽  
Acid Output ◽  
Ulcer Patient ◽  
Cell Mass ◽  
Inverse Correlation ◽  
Normal Subjects ◽  
Gastrin Cell ◽  
Before And After

1. Serum gastrin concentrations before and after a standardized meal were determined in twenty-eight patients with duodenal ulcer and in ten normal control subjects. 2. In response to pentagastrin, thirteen of the duodenal ulcer subjects secreted acid within the limits of normal and fifteen secreted in excess. 3. The differences in the basal serum gastrin concentrations between the three groups, normal subjects, acid ‘normosecretors’ and hypersecretors were not statistically significant but that of the hypersecretors was suggestively low. 4. The integrated gastrin response and peak gastrin responses to meals were higher in duodenal ulcer patients with normal acid secretion than in the hypersecretors but the values for the latter were not different from normal subjects. 5. Stabilization of intragastric pH by infusion into the antrum of sodium bicarbonate during the test meal response period did not alter these differences between the two ulcer patient groups. 6. A significant inverse correlation exists between the maximal acid output and the integrated gastrin response in both normal subjects and hypersecreting duodenal ulcer patients. 7. The evidence (a) supports the existence of an inverse relationship between the functioning parietal cell and gastrin cell masses, (b) shows the gastrin response in normosecreting ulcer subjects to be inappropriately high, and (c) suggests that excessive vagotonia exerts trophic effects upon both parietal cell mass and gastrin cell mass.

THE EFFECTS ON GASTRIC EMPTYING OF PROXIMAL GASTRIC VAGOTOMY, AND TRUNCAL VAGOTOMY AND PYLOROPLASTY

1983 ◽  
Vol 4 (6) ◽  
pp. 418-424 ◽  
Author(s):  
I A Donovan ◽  
M Sorgi ◽  
LK Harding ◽  
J Alexander-Williams
Keyword(s):  
Gastric Emptying ◽  
Truncal Vagotomy ◽  
Proximal Gastric Vagotomy

Effects of Helicobacter pylorigastritis on gastric secretion in healthy human beings

1998 ◽  
Vol 274 (6) ◽  
pp. G1011-G1017 ◽  
Author(s):  
Mark Feldman ◽  
Byron Cryer ◽  
Edward Lee
Keyword(s):  
Gastric Secretion ◽  
Gastric Acidity ◽  
Serum Gastrin ◽  
Acid Output ◽  
Human Beings ◽  
Healthy Human ◽  
Women Subjects ◽  
Before And After ◽  
H Pylori ◽  
Antibody Levels

Helicobacter pylori gastritis is common, but effects on gastric secretion are not well understood. We measured basal and pentagastrin-stimulated gastric acidity, pepsin activity, and fluid output, as well as serum gastrin concentrations and H. pylori antibody levels, before and after treatment of H. pylori gastritis in 28 men and women. Subjects were studied before and 1 and 3 mo after a course of bismuth, metronidazole, and tetracycline. Elimination of H. pylori gastritis, accomplished in 14 subjects, increased basal and pentagastrin-stimulated gastric acidity (by 15 meq/l) and basal acid output significantly (by 2.1 meq/h 1 mo after therapy). Elimination of H. pylori had an opposite effect on pepsin secretion, significantly decreasing pepsin output by 30%. Elimination of H. pylori significantly reduced nonparietal fluid output by 35%, without affecting fluid output from parietal cells. Serum gastrin and H. pylori antibody levels declined significantly after elimination of H. pylori. None of these changes was observed in 14 subjects whose H. pylori gastritis was resistant to antimicrobial therapy. In summary, eradication of H. pylori infection increases gastric acidity by reducing nonparietal gastric secretion from peptic and other cells.

The Effect of Sub-Threshold Doses of Pentagastrin on the Acid Response to Insulin in Duodenal Ulcer Subjects before and after Truncal Vagotomy

1972 ◽  
Vol 43 (2) ◽  
pp. 201-207 ◽  
Author(s):  
J. B. Elder ◽  
G. Gillespie ◽  
I. E. Gillespie ◽  
G. P. Crean ◽  
A. W. Kay ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Acid Output ◽  
Insulin Response ◽  
Truncal Vagotomy ◽  
Gastric Acid Output ◽  
Cholinergic Stimulation ◽  
Response Curves ◽  
Small Doses ◽  
Before And After ◽  
Threshold Doses

1. On the basis of previously described dose-response curves, small doses of pentagastrin were infused in duodenal ulcer patients before and after vagotomy. No increase or decrease in gastric acid output was noted, confirming that the doses of pentagastrin used were sub-threshold. 2. In twenty-six duodenal ulcer patients the effect of sub-threshold doses of pentagastrin on the insulin response resulted in three distinct patterns. (i) In subjects with clearly functioning vagal pathways, no increase in acid output occurred after insulin when a sub-threshold dose of pentagastrin was added; (ii) patients with equivocal acid responses to insulin alone showed augmentation of acid output when given insulin and a sub-threshold pentagastrin infusion; (iii) patients with no response to insulin after truncal vagotomy showed some increase in acid output to the combined agents, and in two patients, criteria for a clearly positive acid response were satisfied. 3. We conclude from these studies that potentiation exists between insulin-induced cholinergic stimulation and infusion of sub-threshold doses of pentagastrin in man.

Gastric emptying of glucose solution and associated plasma concentrations of GLP-1, GIP, and PYY before and after fundoplication

2007 ◽  
Vol 21 (2) ◽  
pp. 309-314 ◽  
Author(s):  
J. Miholic ◽  
M. Hoffmann ◽  
J.J. Holst ◽  
J. Lenglinger ◽  
M. Mittlböck ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Glucose Solution ◽  
Plasma Concentrations ◽  
Before And After

Effect of vagotomy on the acid response to gastric distension

1970 ◽  
Vol 48 (10) ◽  
pp. 670-674 ◽  
Author(s):  
R. M. Preshaw
Keyword(s):  
Motor Activity ◽  
Gastric Acid ◽  
Motor Response ◽  
Acid Output ◽  
The Body ◽  
Conscious Dogs ◽  
Truncal Vagotomy ◽  
Gastric Distension ◽  
Gastric Acid Output

Distension of the body of the stomach, in conscious dogs with vagally innervated antral pouches, caused an increase in gastric acid output, and an increase in antral motor activity. Truncal vagotomy inhibited the acid response to distension, but had no effect on the antral motor response. Denervation of the antral pouch by separating it from the main stomach caused little further diminution in the response.

Adaptation to high-fat diet accelerates emptying of fat but not carbohydrate test meals in humans

2002 ◽  
Vol 282 (2) ◽  
pp. R366-R371 ◽  
Author(s):  
K. E. Castiglione ◽  
N. W. Read ◽  
S. J. French
Keyword(s):  
Gastric Emptying ◽  
Dietary Intake ◽  
Test Meal ◽  
High Fat Diet ◽  
Lag Phase ◽  
High Fat ◽  
Free Living ◽  
Gastric Emptying Rate ◽  
High Carbohydrate ◽  
Before And After

Previous work has shown that the gastric emptying rate in animals and humans can adapt due to previous dietary intake. The present study investigated whether adaptation in gastric emptying rate due to consumption of a high-fat diet (HFD) is nutrient specific in humans. Gastric emptying of high-fat and high-carbohydrate test meals was measured (using gamma scintigraphy) before and after consumption of an HFD for 14 days in eight free-living male volunteers. Visual analog ratings of appetite were recorded throughout each test. There was no effect of HFD on any parameters of gastric emptying rate (lag phase, half-emptying time, and linear emptying rate) measured for carbohydrate test meals. HFD led to an acceleration of the linear emptying rate of the high-fat test meal (0.36 vs. 0.47%/min; P < 0.05). All meals reduced appetite ratings, but there were no differences between tests. These results support our previous findings of accelerated gastric emptying of high-fat test meals following an HFD and show that these changes appear to be nutrient specific, confirming recent studies in rats.

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