Effect of vagotomy on the acid response to gastric distension

1970 ◽  
Vol 48 (10) ◽  
pp. 670-674 ◽  
Author(s):  
R. M. Preshaw
Keyword(s):  
Motor Activity ◽  
Gastric Acid ◽  
Motor Response ◽  
Acid Output ◽  
The Body ◽  
Conscious Dogs ◽  
Truncal Vagotomy ◽  
Gastric Distension ◽  
Gastric Acid Output

Distension of the body of the stomach, in conscious dogs with vagally innervated antral pouches, caused an increase in gastric acid output, and an increase in antral motor activity. Truncal vagotomy inhibited the acid response to distension, but had no effect on the antral motor response. Denervation of the antral pouch by separating it from the main stomach caused little further diminution in the response.

Meal-stimulated absorption of water and electrolytes in canine jejunum

1990 ◽  
Vol 259 (3) ◽  
pp. G402-G409
Author(s):  
C. J. Yeo ◽  
J. A. Bastidas ◽  
R. E. Schmieg ◽  
M. J. Zinner
Keyword(s):  
Gastric Acid ◽  
Acid Output ◽  
Gastric Distension ◽  
Gastric Balloon ◽  
Gastric Acid Output ◽  
Standard Meal ◽  
Jejunal Absorption ◽  
Balloon Distension ◽  
Cephalic Phase ◽  
Independent Mechanism

After a meal, the absorption of water and electrolytes from the jejunal lumen increases. This meal-induced jejunal absorption occurs in jejunal segments out of normal gastrointestinal continuity. The experimental model used 25-cm proximal jejunal Thiry-Vella loops in awake dogs (n = 72 observations) to evaluate the mechanisms involved in meal-induced jejunal absorption, seeking to define the source or sources of the proabsorptive signal. Specifically, we evaluated the jejunal absorptive response to a standard meal, a standard meal plus cholinergic blockage using atropine, a sham-fed meal, a gavage-fed meal, and gastric distension with balloon and gavage water. Both the standard meal and the gavage-fed meal induced a prompt, sustained, and significant (P less than 0.0001) increase in the absorption of H2O, Na+, and Cl-. Atropine significantly reduced the magnitude of the postmeal absorptive response (P less than 0.05) compared with the standard meal alone. The sham-fed meal, gastric balloon distension, and gavage water did not alter jejunal absorption. Vagal nerve integrity after cervical esophageal manipulation was verified by gastric acid output and gastrin response to stimuli. These data support a role for cholinergic modulation of meal-stimulated jejunal absorption via a cephalic-phase-independent and gastric-distension-independent mechanism.

scholarly journals PAC1 Deficiency in a Murine Model Induces Gastric Mucosa Hypertrophy and Higher Basal Gastric Acid Output

2010 ◽  
Vol 43 (1) ◽  
pp. 76-84 ◽  
Author(s):  
Yuxin Lu ◽  
Patrizia Germano ◽  
Gordon V. Ohning ◽  
John P. Vu ◽  
Joseph R. Pisegna
Keyword(s):  
Gastric Mucosa ◽  
Gastric Acid ◽  
Murine Model ◽  
Acid Output ◽  
Gastric Acid Output

scholarly journals A new method for determining gastric acid output using a wireless pH-sensing capsule

2013 ◽  
Vol 37 (12) ◽  
pp. 1198-1209 ◽  
Author(s):  
D. H. Weinstein ◽  
S. deRijke ◽  
C. C. Chow ◽  
L. Foruraghi ◽  
X. Zhao ◽  
...  
Keyword(s):  
Gastric Acid ◽  
Acid Output ◽  
New Method ◽  
Ph Sensing ◽  
Gastric Acid Output

Gastric effects of TRH analogue and bicuculline injected into dorsal motor vagal nucleus in cats

1990 ◽  
Vol 259 (2) ◽  
pp. G321-G326 ◽  
Author(s):  
H. S. Feng ◽  
R. B. Lynn ◽  
J. Han ◽  
F. P. Brooks
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Acid Output ◽  
Motor Nucleus ◽  
Inhibitory Influence ◽  
Gastric Acid Output ◽  
Minimal Effective Dose ◽  
Gabaa Receptor Antagonist ◽  
Dose Dependent

We investigated the gastric acid secretory and motility responses to microinjection into the dorsal motor nucleus of the vagus (DMV) of RX 77368, a stable thyrotropin-releasing hormone (TRH) analogue, and bicuculline, a gamma-aminobutyric acid (GABAA) receptor antagonist in ketamine-chloralose-anesthetized cats. Gastric acid output was collected every 15 min through a gastric cannula after saline flush and titrated to pH 7.0. Antral contractions were continuously recorded by an extraluminal strain gauge force transducer. The chemicals were dissolved in saline and unilaterally microinjected in volumes of 200 nl. RX 77368 or bicuculline microinjected into the DMV induced significant dose-dependent (50-500 ng) increases in gastric acid secretion and significant dose-dependent (50-200 ng) increases in the force of antral contractions. In response to both chemicals the gastric acid output increased in the first 15 min and peaked in the second and third collections. RX 77368 (500 ng) had a second greater peak 90 min after microinjection. The motility responses were rapid in onset and lasted 60 min for RX 77368 and 30 min for bicuculline. The minimal effective dose for eliciting increased motility was consistently lower than inducing acid secretion. Electrical stimulation of the DMV with 100 microA, 50-Hz, and 0.2-ms pulse duration increased the force of antral contractions but had no effect on gastric acid secretion. Our results demonstrate that the DMV exerts important control over both gastric acid secretion and motility in cats. TRH exerts a stimulatory influence, while GABAA receptors mediate an inhibitory influence on this vagal control.

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