Engineering a Thermostable Chondroitinase for Production of Specifically Distributed Low‐Molecular‐Weight Chondroitin Sulfate

2020 ◽  
pp. 2000321
Author(s):  
Hao Wang ◽  
Lin Zhang ◽  
Yang Wang ◽  
Jianghua Li ◽  
Guocheng Du ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Chondroitin Sulfate ◽  
Low Molecular Weight

scholarly journals In Vivo Anti-Cancer Mechanism of Low-Molecular-Weight Fucosylated Chondroitin Sulfate (LFCS) from Sea Cucumber Cucumaria frondosa

Molecules ◽  
2016 ◽  
Vol 21 (5) ◽  
pp. 625 ◽  
Author(s):  
Xiaoxiao Liu ◽  
Yong Liu ◽  
Jiejie Hao ◽  
Xiaoliang Zhao ◽  
Yinzhi Lang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Chondroitin Sulfate ◽  
Sea Cucumber ◽  
Low Molecular Weight ◽  
Anti Cancer ◽  
Cucumaria Frondosa

scholarly journals Effects of Low Molecular Weight Chondroitin Sulfate on Type II Collagen-Induced Arthritis in DBA/1J Mice

2004 ◽  
Vol 27 (1) ◽  
pp. 47-51 ◽  
Author(s):  
So Yean Cho ◽  
Joon-Soo Sim ◽  
Choon Sik Jeong ◽  
Seung Yeup Chang ◽  
Don Woong Choi ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Chondroitin Sulfate ◽  
Type Ii Collagen ◽  
Low Molecular Weight ◽  
Type Ii ◽  
Collagen Induced Arthritis

scholarly journals (Semi)-Synthetic Fucosylated Chondroitin Sulfate Oligo- and Polysaccharides

Marine Drugs ◽  
2020 ◽  
Vol 18 (6) ◽  
pp. 293
Author(s):  
Giulia Vessella ◽  
Serena Traboni ◽  
Antonio Laezza ◽  
Alfonso Iadonisi ◽  
Emiliano Bedini
Keyword(s):  
Molecular Weight ◽  
Chondroitin Sulfate ◽  
Anticoagulant Activity ◽  
Structural Heterogeneity ◽  
Low Molecular Weight ◽  
Total Syntheses ◽  
Multiple Copies ◽  
Synthetic Approaches ◽  
First Time ◽  
Made In

Fucosylated chondroitin sulfate (fCS) is a glycosaminoglycan (GAG) polysaccharide with a unique structure, displaying a backbone composed of alternating N-acetyl-d-galactosamine (GalNAc) and d-glucuronic acid (GlcA) units on which l-fucose (Fuc) branches are installed. fCS shows several potential biomedical applications, with the anticoagulant activity standing as the most promising and widely investigated one. Natural fCS polysaccharides extracted from marine organisms (Echinoidea, Holothuroidea) present some advantages over a largely employed antithrombotic drug such as heparin, but some adverse effects as well as a frequently found structural heterogeneity hamper its development as a new drug. To circumvent these drawbacks, several efforts have been made in the last decade to obtain synthetic and semi-synthetic fCS oligosaccharides and low molecular weight polysaccharides. In this Review we have for the first time collected these reports together, dividing them in two topics: (i) total syntheses of fCS oligosaccharides and (ii) semi-synthetic approaches to fCS oligosaccharides and low molecular weight polysaccharides as well as glycoclusters displaying multiple copies of fCS species.

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