scholarly journals Oversulfated Chondroitin Sulfate: Impact of a Heparin Impurity, Associated with Adverse Clinical Events, on Low-Molecular-Weight Heparin Preparation

2008 ◽  
Vol 51 (18) ◽  
pp. 5498-5501 ◽  
Author(s):  
Zhenqing Zhang ◽  
Michel Weïwer ◽  
Boyangzi Li ◽  
Melissa M. Kemp ◽  
Tyler H. Daman ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Chondroitin Sulfate ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Clinical Events ◽  
Oversulfated Chondroitin Sulfate ◽  
Heparin Preparation

Influence of Low Molecular Weight Heparin on the Hemostatic System After Abdominal Surgery

1985 ◽  
Vol 53 (03) ◽  
pp. 297-300 ◽  
Author(s):  
U Schmitz-Huebner ◽  
C Rüschemeyer ◽  
H Schulte ◽  
J van de Loo
Keyword(s):  
Molecular Weight ◽  
Abdominal Surgery ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Total Blood ◽  
Treatment Groups ◽  
Hemostatic System ◽  
Heparin Fractions ◽  
Molecular Weight Fractions ◽  
Heparin Preparation

SummaryThe hemostatic effect of two low molecular weight heparin fractions and of one unfractionated heparin preparation administered subcutaneously b. i. d. was examined in 6 healthy subjects and in 53 patients after major abdominal surgery. Among other tests platelet count, prothrombin time, fibrinogen, β-thrombo- globulin, antithrombin, antiplasmin, FPA and F-CB 3 related antigen, as well as various heparin activities, were repeatedly determined pre- and postoperatively. Under all tested conditions the low molecular weight fractions induced higher heparin levels, both in terms of anti-Xa and of anti-thrombin activity. No further significant differences of the laboratory results between the treatment groups were documented. Total blood loss measured at the first postoperative day was higher in patients with malignancy and negatively correlated with antithrombin and antiplasmin levels, while no relation was observed with the heparin activities and the other tested parameters. Whereas evidence for a hemorrhagic property of the tested low molecular weight heparin fractions was found, a particular mechanism underlying this effect could not be identified.

Low-molecular-weight heparin in the prevention and treatment of thromboembolic disorders

1998 ◽  
Vol 1 (5) ◽  
pp. 166-174 ◽  
Author(s):  
Evelyn R Hermes De Santis ◽  
Betsy S Laumeister ◽  
Vidhu Bansal ◽  
Vandana Kataria ◽  
Preeti Loomba ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Prevention And Treatment
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