scholarly journals Effects of Low Molecular Weight Chondroitin Sulfate on Type II Collagen-Induced Arthritis in DBA/1J Mice

2004 ◽  
Vol 27 (1) ◽  
pp. 47-51 ◽  
Author(s):  
So Yean Cho ◽  
Joon-Soo Sim ◽  
Choon Sik Jeong ◽  
Seung Yeup Chang ◽  
Don Woong Choi ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Chondroitin Sulfate ◽  
Type Ii Collagen ◽  
Low Molecular Weight ◽  
Type Ii ◽  
Collagen Induced Arthritis

Biocompatibility assessment of type-II collagen and its polypeptide for tissue engineering: effect of collagen's molecular weight and glycoprotein content on tumor necrosis factor (Fas/Apo-1) receptor activation in human acute T-lymphocyte leukemia cell line

RSC Advances ◽  
2016 ◽  
Vol 6 (17) ◽  
pp. 14236-14246 ◽  
Author(s):  
E. Jeevithan ◽  
Z. Jingyi ◽  
B. Bao ◽  
W. Shujun ◽  
R. JeyaShakila ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Leukemia Cell ◽  
Death Receptor ◽  
Type Ii Collagen ◽  
Receptor Activation ◽  
Leukemia Cell Line ◽  
Low Molecular Weight ◽  
Type Ii ◽  
Line P ◽  
Necrosis Factor

Fas cell surface death receptor activation by low molecular weight (57, 40 and 25 kDa) collagens was investigated based on MW and glycoprotein content.

Effect of a novel anti-rheumatic drug, TA-383, on type II collagen-induced arthritis

1995 ◽  
Vol 17 (7) ◽  
pp. 597-603 ◽  
Author(s):  
Makoto Ueno ◽  
Kazunori Imaizumi ◽  
Takahisa Sugita ◽  
Isao Takata ◽  
Masakazu Takeshita
Keyword(s):  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Rheumatic Drug

Evaluation of inflammatory change and bone erosion using a murine type II collagen-induced arthritis model

2010 ◽  
Vol 31 (5) ◽  
pp. 595-603 ◽  
Author(s):  
Samjin Choi ◽  
Yeon-Ah Lee ◽  
Seung-Jae Hong ◽  
Gi-Ja Lee ◽  
Sung Wook Kang ◽  
...  
Keyword(s):  
Bone Erosion ◽  
Type Ii Collagen ◽  
Inflammatory Change ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Arthritis Model

scholarly journals In Vivo Anti-Cancer Mechanism of Low-Molecular-Weight Fucosylated Chondroitin Sulfate (LFCS) from Sea Cucumber Cucumaria frondosa

Molecules ◽  
2016 ◽  
Vol 21 (5) ◽  
pp. 625 ◽  
Author(s):  
Xiaoxiao Liu ◽  
Yong Liu ◽  
Jiejie Hao ◽  
Xiaoliang Zhao ◽  
Yinzhi Lang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Chondroitin Sulfate ◽  
Sea Cucumber ◽  
Low Molecular Weight ◽  
Anti Cancer ◽  
Cucumaria Frondosa

scholarly journals Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Corina Peña ◽  
David Gárate ◽  
Juan Contreras-Levicoy ◽  
Octavio Aravena ◽  
Diego Catalán ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Combined Treatment ◽  
Type Ii Collagen ◽  
Cytokine Profile ◽  
Clinical Disease ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Short Term

Background. Pharmacologically modulated dendritic cells (DCs) have been shown to restore tolerance in type II collagen-(CII-) induced arthritis (CIA). We examined the effect of dexamethasone (DXM) administration as a preconditioning agent, followed by an injection of lipopolysaccharide-(LPS-) stimulated and CII-loaded DCs on the CIA course.Methods. After CIA induction, mice pretreated with DXM were injected with 4-hour LPS-stimulated DCs loaded with CII (DXM/4hLPS/CII/DCs).Results. Mice injected with DXM/4hLPS/CII/DCs displayed significantly less severe clinical disease compared to animals receiving 4hLPS/CII/DCs alone or those in which only DXM was administered. Cytokine profile evaluation showed that CD4+ T cells from DXM/4hLPS/CII/DCs and 4hLPS/CII/DCs groups release higher IL-10 levels than those from mice receiving DXM alone or CIA mice. CD4+ T cells from all DC-treated groups showed less IL-17 release when compared to the CIA group. On the contrary, CD4+ T cells from DXM/4hLPS/CII/DCs and 4hLPS/CII/DCs groups released higher IFN-γlevels than those from CIA group.Conclusion. A combined treatment, including DXM preconditioning followed by an inoculation of short-term LPS-stimulated CII-loaded DCs, provides an improved strategy for attenuating CIA severity. Our results suggest that this benefit is driven by a modulation in the cytokine profile secreted by CD4+ T cells.

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