Surveillance of congenital malformations in infants conceived through assisted reproductive technology or other fertility treatments

2015 ◽  
Vol 103 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Angela S. Heisey ◽  
Erin M. Bell ◽  
Michele L. Herdt-Losavio ◽  
Charlotte Druschel
Keyword(s):  
Assisted Reproductive Technology ◽  
Congenital Malformations ◽  
Reproductive Technology ◽  
Fertility Treatments

Congenital malformations associated with assisted reproductive technology: A California statewide analysis

2013 ◽  
Vol 48 (6) ◽  
pp. 1218-1224 ◽  
Author(s):  
Lorraine I. Kelley-Quon ◽  
Chi-Hong Tseng ◽  
Carla Janzen ◽  
Stephen B. Shew
Keyword(s):  
Assisted Reproductive Technology ◽  
Congenital Malformations ◽  
Reproductive Technology

Estimation of the Contribution of Assisted and Non-Assisted Reproductive Technology Fertility Treatments to Multiple Births During the Past 30 Years in Japan: 1979–2008

2011 ◽  
Vol 14 (5) ◽  
pp. 476-483 ◽  
Author(s):  
Syuichi Ooki
Keyword(s):  
Assisted Reproductive Technology ◽  
Social Impact ◽  
Vital Statistics ◽  
Reproductive Technology ◽  
Multiple Births ◽  
Fertility Treatment ◽  
Approximation Formula ◽  
Multiple Birth ◽  
Fertility Treatments ◽  
Ovulation Stimulation

The effect of assisted reproductive technology (ART) and non-ART ovulation stimulation fertility treatment on the number and rate of multiple live births from 1979–2008 in Japan was estimated using two independent data sources, ART statistics and vital statistics. Japanese ART statistics presented by the Japan Society of Obstetrics and Gynecology between 1989 and 2008 were gathered and reanalyzed. The number and rates of ART between 1984 and 1988 were interpolated using an approximation formula, using the values from 1983, when the first ART baby was born in Japan, and the 1989–1992 values. The number of ART multiples between 1979–1982 was set as equal to zero. The minimum (or maximum) number of non-ART iatrogenic multiple births was estimated by subtracting the maximum (or minimum) ART multiples from the total iatrogenic multiples, which was estimated by vital statistics assuming that spontaneous multiple-birth rates according to maternal age class would be constant. There was an overall increase in the non-ART multiple births during the 30-year period, whereas ART multiples tended to increase from 1983 to 2005, and then rapidly decreased thereafter. The number or percentage of ART multiples was almost consistently lower than that of non-ART multiples. The percentage of non-ART multiples (33%) among the total multiples was estimated to be about three times more than the ART multiples (11–12%) in 2008. Given the medical and social impact of multiple births, it is imperative to construct a hospital-based monitoring system for fertility treatments, specially non-ART fertility treatments and multiple births.

scholarly journals Congenital malformations and minor anomalies in newborns depending on the type of resolved infertility and health of the parents

2021 ◽  
pp. 22-28
Author(s):  
M. K. Soboleva ◽  
D. A. Кinsht
Keyword(s):  
Assisted Reproductive Technology ◽  
Congenital Malformations ◽  
Medical Center ◽  
Reproductive Technologies ◽  
Reproductive Technology ◽  
Blastocyst Stage ◽  
Fertility Treatment ◽  
Complete Continuity ◽  
History Of ◽  
Minor Anomalies

Introduction. The use of  sisted reproductive technologies has had sufficient experience to reduce the risks associated with the technologies themselves. But pediatricians remain concerned about the health of children born from induced pregnancies because of the influence of the parents’ initial health on perinatal outcomes. Congenital malformations remain socially significant, the risk of which may be higher for children from induced pregnancy.Objective: to evaluate the effect of initial parental health and the methods of assisted reproductive technology used on the formation of congenital malformations and minor anomalies in children from singleton induced pregnancies.Materials and Methods. A retrospective cohort study was conducted using data on live-born children from singleton induced pregnancy born at the Avicenna Medical Center (Novosibirsk) over the period from 2007 to 2017 (n = 409). The reproductive, somatic, and infectious history of the parents and the methods of assisted reproductive technology used were assessed. Parental fertility treatment up to childbirth was performed in the same center, which ensured complete continuity of follow-up. Differences between the groups of children from SIP with and without congenital anomalies were determined using Pearson’s chi-squared test.Results and discussion. We found that children with congenital malformations and minor anomalies were more often born as a result of subsequent pregnancies; thawed embryos transferred at the blastocyst stage were used in assisted reproductive technology programs (p < 0.05); exacerbations of herpes type 2 infection were diagnosed during the current pregnancy (p < 0.05). In the group of children with only CM, the parents had a longer history of infertility (8.3 ± 1.2) years; pregnancy was achieved by transferring fresh embryos at the blastocyst stage (in 68.2% of cases). In the group of children without congenital malformations and minor anomalies, the maternal infectious history was more severe: there were significantly more frequent cases of urogenital infections (p < 0.05) and exacerbations of herpes simplex virus type 1 during pregnancy (p < 0.05).Conclusion. A set of measures aimed at an earlier solution of the infertility problem is necessary for the primary prevention of congenital abnormalities associated with the age and duration of parental infertility.

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